Annotation Detail for KPNA1
Basic Information Top
| Gene Symbol: | KPNA1 ( IPOA5,NPI-1,RCH2,SRP1 ) |
|---|---|
| Gene Full Name: | karyopherin alpha 1 (importin alpha 5) |
| Band: | 3q21.1 |
| Quick Links | Entrez ID:3836; OMIM: 600686; Uniprot ID:IMA1_HUMAN; ENSEMBL ID: ENSG00000114030; HGNC ID: 6394 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.161008
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 6 / 70761 | 84 |  |
| blastocyst | 11 / 62319 | 176 | |
| fetus | 57 / 564012 | 101 | |
| neonate | 3 / 31097 | 96 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 3 / 55556 | 53 | |
| adult | 151 / 1939121 | 77 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 1 / 17475 | 57 | |
| breast (mammary gland) tumor | 5 / 94178 | 53 | |
| cervical tumor | 2 / 34366 | 58 | |
| chondrosarcoma | 6 / 82823 | 72 | |
| colorectal tumor | 2 / 114246 | 17 |  |
| esophageal tumor | 2 / 17290 | 115 | |
| gastrointestinal tumor | 6 / 119369 | 50 | |
| germ cell tumor | 30 / 263845 | 113 | |
| glioma | 7 / 106883 | 65 | |
| head and neck tumor | 18 / 136302 | 132 | |
| kidney tumor | 4 / 68959 | 58 | |
| leukemia | 3 / 95842 | 31 | |
| liver tumor | 6 / 96359 | 62 | |
| lung tumor | 10 / 103127 | 96 | |
| lymphoma | 4 / 71755 | 55 | |
| non-neoplasia | 10 / 97250 | 102 | |
| normal | 333 / 3360307 | 99 | |
| ovarian tumor | 3 / 76682 | 39 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 8 / 102680 | 77 | |
| retinoblastoma | 3 / 46356 | 64 | |
| skin tumor | 9 / 124949 | 72 | |
| soft tissue/muscle tissue tumor | 5 / 125191 | 39 | |
| uterine tumor | 5 / 90257 | 55 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 3 / 40015 | 74 | |
| bladder | 2 / 29757 | 67 | |
| blood | 6 / 123478 | 48 | |
| bone | 5 / 71655 | 69 | |
| bone marrow | 2 / 48801 | 40 | |
| brain | 119 / 1100989 | 108 | |
| cervix | 8 / 48171 | 166 | |
| connective tissue | 9 / 149255 | 60 | |
| ear | 1 / 16212 | 61 | |
| embryonic tissue | 21 / 215722 | 97 | |
| esophagus | 2 / 20209 | 98 | |
| eye | 16 / 211054 | 75 | |
| heart | 3 / 89626 | 33 | |
| intestine | 12 / 234472 | 51 | |
| kidney | 18 / 211777 | 84 | |
| larynx | 2 / 24145 | 82 | |
| liver | 21 / 207743 | 101 | |
| lung | 20 / 336974 | 59 | |
| lymph | 4 / 44270 | 90 | |
| lymph node | 3 / 91610 | 32 | |
| mammary gland | 10 / 153271 | 65 | |
| mouth | 12 / 67052 | 178 | |
| muscle | 15 / 107715 | 139 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 5 / 102051 | 48 | |
| pancreas | 1 / 214812 | 4 |  |
| parathyroid | 3 / 20539 | 146 | |
| pharynx | 4 / 41328 | 96 | |
| pituitary gland | 2 / 16585 | 120 | |
| placenta | 27 / 280825 | 96 | |
| prostate | 13 / 189345 | 68 | |
| salivary gland | 1 / 20155 | 49 | |
| skin | 21 / 210574 | 99 | |
| spleen | 6 / 53952 | 111 | |
| stomach | 5 / 96619 | 51 | |
| testis | 58 / 330442 | 175 | |
| thymus | 5 / 81131 | 61 | |
| thyroid | 2 / 47473 | 42 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 5 / 52413 | 95 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 21 / 232878 | 90 | |
| vascular | 10 / 51780 | 193 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 202056_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.9 | |
| Adipocyte | 3.7 | |
| AdrenalCortex | 4 | |
| Adrenalgland | 3.2 | |
| Amygdala | 4 | |
| Appendix | 3.95 | |
| AtrioventricularNode | 3.05 | |
| BDCA4+_DentriticCells | 6.15 | |
| Bonemarrow | 3.75 | |
| BronchialEpithelialCells | 3.7 | |
| CD105+_Endothelial | 29.1 | |
| CD14+_Monocytes | 4.6 | |
| CD19+_BCells(neg._sel.) | 4.05 | |
| CD33+_Myeloid | 5.8 | |
| CD34+ | 16 | |
| CD4+_Tcells | 5.15 | |
| CD56+_NKCells | 4.6 | |
| CD71+_EarlyErythroid | 3.75 | |
| CD8+_Tcells | 5.3 | |
| CardiacMyocytes | 4.9 | |
| Caudatenucleus | 3.35 | |
| Cerebellum | 3 | |
| CerebellumPeduncles | 4.25 | |
| CiliaryGanglion | 2.8 | |
| CingulateCortex | 3.85 | |
| Colorectaladenocarcinoma | 3.75 | |
| DorsalRootGanglion | 2.95 | |
| FetalThyroid | 3.65 | |
| Fetalbrain | 7.6 | |
| Fetalliver | 3.25 | |
| Fetallung | 3.1 | |
| GlobusPallidus | 2.8 | |
| Heart | 4.85 | |
| Hypothalamus | 4.15 | |
| Kidney | 3.05 | |
| Leukemia_chronicMyelogenousK-562 | 3.4 | |
| Leukemia_promyelocytic-HL-60 | 3.3 | |
| Leukemialymphoblastic(MOLT-4) | 3 | |
| Liver | 5 | |
| Lung | 4.1 | |
| Lymphnode | 3.25 | |
| Lymphoma_burkitts(Daudi) | 4.8 | |
| Lymphoma_burkitts(Raji) | 5.25 | |
| MedullaOblongata | 3.45 | |
| OccipitalLobe | 3.35 | |
| OlfactoryBulb | 2.95 | |
| Ovary | 2.5 | |
| Pancreas | 3 | |
| PancreaticIslet | 4 | |
| ParietalLobe | 4 | |
| Pituitary | 4.35 | |
| Placenta | 3.9 | |
| Pons | 3.55 | |
| PrefrontalCortex | 4.7 | |
| Prostate | 4.4 | |
| Salivarygland | 3 | |
| SkeletalMuscle | 4.5 | |
| Skin | 2.95 | |
| SmoothMuscle | 4.25 | |
| Spinalcord | 4.05 | |
| SubthalamicNucleus | 3.45 | |
| SuperiorCervicalGanglion | 4.35 | |
| TemporalLobe | 3.45 | |
| Testis | 3.2 | |
| TestisGermCell | 3.15 | |
| TestisIntersitial | 3.15 | |
| TestisLeydigCell | 3.75 | |
| TestisSeminiferousTubule | 3.25 | |
| Thalamus | 3.8 | |
| Thymus | 2.95 | |
| Thyroid | 4.7 | |
| Tongue | 3.7 | |
| Tonsil | 3.65 | |
| Trachea | 3.1 | |
| TrigeminalGanglion | 3.8 | |
| Uterus | 3.15 | |
| UterusCorpus | 3.45 | |
| WholeBlood | 4.15 | |
| Wholebrain | 3.25 | |
| colon | 3.8 | |
| pineal_day | 8.24 | |
| pineal_night | 7.34 | |
| retina | 4.525 | |
| small_intestine | 3.6 | |
- Probe name: A_23_P351055
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.07 ± 0.31 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.65 ± 0.22 | |
| Basal Part of Pons | 5.9 ± 0.37 | |
| Cerebellar Cortex | 5.49 ± 0.34 | |
| Cerebellar Nuclei | 6.08 ± 0.2 | |
| Claustrum | 6.47 ± 0.4 | |
| Epithalamus | 5.43 ± 0.36 | |
| Frontal Lobe | 5.78 ± 0.39 | |
| Globus Pallidus | 5.82 ± 0.27 | |
| Hypothalamus | 5.69 ± 0.36 | |
| Insula | 5.73 ± 0.3 | |
| Limbic Lobe | 5.94 ± 0.4 | |
| Mesencephalon | 5.85 ± 0.51 | |
| Myelencephalon | 5.78 ± 0.37 | |
| Occipital Lobe | 5.94 ± 0.34 | |
| Parietal Lobe | 5.85 ± 0.39 | |
| Pontine Tegmentum | 5.75 ± 0.34 | |
| Striatum | 5.7 ± 0.42 | |
| Subthalamus | 5.9 ± 0.34 | |
| Temporal Lobe | 5.77 ± 0.39 | |
| Thalamus | 5.72 ± 0.31 | |
| White Matter | 6.04 ± 0.37 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Kpna1 | CB | Cerebellum | 47.54 | |
| 46.39 | | |||
| Kpna1 | CTX | Cerebral cortex | 80.86 | |
| 67.2 | | |||
| Kpna1 | HIP | Hippocampal region | 78.72 | |
| 71.47 | | |||
| Kpna1 | HPF | Hippocampal formation | 82.85 | |
| 69.18 | | |||
| Kpna1 | HY | Hypothalamus | 39.01 | |
| 20.74 | | |||
| Kpna1 | LSX | Lateral septal complex | 65.32 | |
| 39.86 | | |||
| Kpna1 | MB | Midbrain | 53.53 | |
| 33.22 | | |||
| Kpna1 | MY | Medulla | 68.6 | |
| 60.37 | | |||
| Kpna1 | OLF | Olfactory bulb | 74.41 | |
| 62.57 | | |||
| Kpna1 | P | Pons | 62.59 | |
| 50.83 | | |||
| Kpna1 | PAL | Pallidum | 39.49 | |
| 26.4 | | |||
| Kpna1 | RHP | Retrohippocampal region | 81.4 | |
| 65.91 | | |||
| Kpna1 | sAMY | Striatum-like amygdalar nuclei | 46.03 | |
| 24.56 | | |||
| Kpna1 | STR | Striatum | 49.11 | |
| 23.7 | | |||
| Kpna1 | STRd | Striatum dorsal region | 48.64 | |
| 22.53 | | |||
| Kpna1 | STRv | Striatum ventral region | 43.93 | |
| 21.34 | | |||
| Kpna1 | TH | Thalamus | 42.08 | |
| 23.98 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| IMA1_HUMAN_2 | 9 | 2 | 10 | TTPGKENFR | PRIDE |
| IMA1_HUMAN_417 | 21 | 417 | 437 | YLVELGCIKPLCDLLTVMDSK | PRIDE |
| PAp00010999 | 11 | 231 | 241 | NAVWALSNLCR | Peptide Atlas |