AutismKB 2.0

Annotation Detail for TNPO1


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Basic Information Top
Gene Symbol:TNPO1 ( IPO2,KPNB2,MIP,MIP1,TRN )
Gene Full Name: transportin 1
Band: 5q13.2
Quick LinksEntrez ID:3842; OMIM: 602901; Uniprot ID:TNPO1_HUMAN; ENSEMBL ID: ENSG00000083312; HGNC ID: 6401
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst14 / 62319224
fetus164 / 564012290
neonate9 / 31097289
infant5 / 23620211
juvenile4 / 5555671
adult227 / 1939121117
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor6 / 12794468
bladder carcinoma0 / 174750 
breast (mammary gland) tumor13 / 94178138
cervical tumor8 / 34366232
chondrosarcoma4 / 8282348
colorectal tumor6 / 11424652
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor71 / 263845269
glioma2 / 10688318
head and neck tumor23 / 136302168
kidney tumor9 / 68959130
leukemia11 / 95842114
liver tumor11 / 96359114
lung tumor3 / 10312729
lymphoma10 / 71755139
non-neoplasia7 / 9725071
normal573 / 3360307170
ovarian tumor6 / 7668278
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer10 / 10268097
retinoblastoma5 / 46356107
skin tumor9 / 12494972
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland13 / 33197391
ascites8 / 40015199
bladder3 / 29757100
blood8 / 12347864
bone8 / 71655111
bone marrow2 / 4880140
brain171 / 1100989155
cervix10 / 48171207
connective tissue12 / 14925580
ear4 / 16212246
embryonic tissue39 / 215722180
esophagus2 / 2020998
eye25 / 211054118
heart9 / 89626100
intestine23 / 23447298
kidney45 / 211777212
larynx2 / 2414582
liver23 / 207743110
lung27 / 33697480
lymph5 / 44270112
lymph node18 / 91610196
mammary gland18 / 153271117
mouth17 / 67052253
muscle25 / 107715232
nerve3 / 15768190
ovary4 / 10205139
pancreas32 / 214812148
parathyroid6 / 20539292
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta49 / 280825174
prostate30 / 189345158
salivary gland3 / 20155148
skin26 / 210574123
spleen6 / 53952111
stomach1 / 9661910
testis66 / 330442199
thymus25 / 81131308
thyroid6 / 47473126
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord2 / 13680146
uterus32 / 232878137
vascular30 / 51780579
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207657_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts504.55
Adipocyte184.5
AdrenalCortex97.25
Adrenalgland69.45
Amygdala44.3
Appendix60.1
AtrioventricularNode29.35
BDCA4+_DentriticCells267.75
Bonemarrow76.15
BronchialEpithelialCells270.65
CD105+_Endothelial160.35
CD14+_Monocytes83.4
CD19+_BCells(neg._sel.)270.35
CD33+_Myeloid169
CD34+389.4
CD4+_Tcells293.7
CD56+_NKCells231.15
CD71+_EarlyErythroid65.95
CD8+_Tcells267.9
CardiacMyocytes126.1
Caudatenucleus40.1
Cerebellum28.1
CerebellumPeduncles50.4
CiliaryGanglion34.8
CingulateCortex91.7
Colorectaladenocarcinoma43.45
DorsalRootGanglion35.4
FetalThyroid379
Fetalbrain164.2
Fetalliver47.45
Fetallung53.05
GlobusPallidus35.65
Heart43
Hypothalamus52.2
Kidney56.25
Leukemia_chronicMyelogenousK-56267.7
Leukemia_promyelocytic-HL-60108.95
Leukemialymphoblastic(MOLT-4)73.3
Liver43.85
Lung63.9
Lymphnode43.25
Lymphoma_burkitts(Daudi)159.65
Lymphoma_burkitts(Raji)55.15
MedullaOblongata76.8
OccipitalLobe62.55
OlfactoryBulb114.95
Ovary26.8
Pancreas85.8
PancreaticIslet64.45
ParietalLobe72.55
Pituitary400.85
Placenta111.65
Pons57.4
PrefrontalCortex148
Prostate264
Salivarygland27.15
SkeletalMuscle62.8
Skin25.6
SmoothMuscle473.2
Spinalcord43.55
SubthalamicNucleus76.25
SuperiorCervicalGanglion55.35
TemporalLobe62.2
Testis62.2
TestisGermCell126.15
TestisIntersitial159.3
TestisLeydigCell91.65
TestisSeminiferousTubule118
Thalamus50.3
Thymus154.45
Thyroid112.3
Tongue107.75
Tonsil101.3
Trachea107.05
TrigeminalGanglion52.3
Uterus148.85
UterusCorpus82.55
WholeBlood193
Wholebrain42.9
colon94.8
pineal_day521.8
pineal_night459.02
retina79.25
small_intestine72.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P260440
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.83 ± 0.5
Basal Forebrain4.91 ± 0.47
Basal Part of Pons4.96 ± 0.17
Cerebellar Cortex5.19 ± 0.36
Cerebellar Nuclei5.04 ± 0.44
Claustrum4.55 ± 0.85
Epithalamus5.29 ± 0.6
Frontal Lobe5.06 ± 0.47
Globus Pallidus5.27 ± 0.29
Hypothalamus4.98 ± 0.79
Insula5.05 ± 0.33
Limbic Lobe4.94 ± 0.54
Mesencephalon5.16 ± 0.55
Myelencephalon4.94 ± 0.54
Occipital Lobe4.97 ± 0.51
Parietal Lobe5.07 ± 0.43
Pontine Tegmentum5.1 ± 0.46
Striatum4.85 ± 0.51
Subthalamus4.5 ± 0.45
Temporal Lobe5.03 ± 0.4
Thalamus4.87 ± 0.53
White Matter5.25 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnpo1CBCerebellum19.01
22.95
Tnpo1CTXCerebral cortex47.07
31.34
Tnpo1HIPHippocampal region33.13
31.98
Tnpo1HPFHippocampal formation32.74
29.22
Tnpo1HYHypothalamus34.7
28.75
Tnpo1LSXLateral septal complex13.78
9.61
Tnpo1MBMidbrain18.26
16.96
Tnpo1MYMedulla22.61
28.3
Tnpo1OLFOlfactory bulb83.44
75.38
Tnpo1PPons20.25
24.25
Tnpo1PALPallidum23.93
21.79
Tnpo1RHPRetrohippocampal region31.36
24.6
Tnpo1sAMYStriatum-like amygdalar nuclei27.52
20.47
Tnpo1STRStriatum21.43
16.73
Tnpo1STRdStriatum dorsal region16.09
12.79
Tnpo1STRvStriatum ventral region36.35
27.35
Tnpo1THThalamus12.39
10.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003710 24 163 186 ICEDSAEILDSDVLDRPLNIMIPK Peptide Atlas
TNPO1_HUMAN_0 0 0 0 TLLENTAITIGR PRIDE
TNPO1_HUMAN_154 24 154 177 ICEDSAEILDSDVLDRPLNIMIPK PRIDE
TNPO1_HUMAN_249 15 249 263 LLPHMHNIVEYMLQR PRIDE
TNPO1_HUMAN_377 26 377 402 CSAAALDVLANVYRDELLPHILPLLK PRIDE
TNPO1_HUMAN_765 12 765 776 TLLENTAITIGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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