AutismKB 2.0

Annotation Detail for KRT6A


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Basic Information Top
Gene Symbol:KRT6A ( CK6A,CK6C,CK6D,K6A,K6C,K6D,KRT6C,KRT6D )
Gene Full Name: keratin 6A
Band: 12q13.13
Quick LinksEntrez ID:3853; OMIM: 148041; Uniprot ID:K2C6A_HUMAN; ENSEMBL ID: ENSG00000205420; HGNC ID: 6443
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult986 / 1939121508
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma29 / 174751659
breast (mammary gland) tumor0 / 941780 
cervical tumor2 / 3436658
chondrosarcoma0 / 828230 
colorectal tumor9 / 11424678
esophageal tumor168 / 172909716
gastrointestinal tumor3 / 11936925
germ cell tumor0 / 2638450 
glioma237 / 1068832217
head and neck tumor775 / 1363025685
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor9 / 10312787
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal502 / 3360307149
ovarian tumor16 / 76682208
pancreatic tumor48 / 104616458
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer20 / 102680194
retinoblastoma0 / 463560 
skin tumor145 / 1249491160
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor36 / 90257398
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder29 / 29757974
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain248 / 1100989225
cervix33 / 48171685
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus190 / 202099401
eye7 / 21105433
heart3 / 8962633
intestine9 / 23447238
kidney1 / 2117774
larynx181 / 241457496
liver0 / 2077430 
lung20 / 33697459
lymph0 / 442700 
lymph node0 / 916100 
mammary gland13 / 15327184
mouth394 / 670525876
muscle4 / 10771537
nerve0 / 157680 
ovary16 / 102051156
pancreas48 / 214812223
parathyroid0 / 205390 
pharynx354 / 413288565
pituitary gland0 / 165850 
placenta77 / 280825274
prostate147 / 189345776
salivary gland0 / 201550 
skin179 / 210574850
spleen0 / 539520 
stomach3 / 9661931
testis2 / 3304426
thymus10 / 81131123
thyroid34 / 47473716
tonsil0 / 169990 
trachea20 / 52413381
umbilical cord0 / 136800 
uterus73 / 232878313
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214580_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.25
Adipocyte4.45
AdrenalCortex5
Adrenalgland3.85
Amygdala4.6
Appendix4.85
AtrioventricularNode3.7
BDCA4+_DentriticCells5
Bonemarrow4.5
BronchialEpithelialCells533.35
CD105+_Endothelial4.55
CD14+_Monocytes4.75
CD19+_BCells(neg._sel.)4.85
CD33+_Myeloid5.95
CD34+5.65
CD4+_Tcells4.75
CD56+_NKCells5.3
CD71+_EarlyErythroid4.2
CD8+_Tcells4.15
CardiacMyocytes6.15
Caudatenucleus4.1
Cerebellum3.65
CerebellumPeduncles6.9
CiliaryGanglion3.4
CingulateCortex4.65
Colorectaladenocarcinoma4.45
DorsalRootGanglion4.1
FetalThyroid4.3
Fetalbrain4.5
Fetalliver4.6
Fetallung3.55
GlobusPallidus3.35
Heart6.05
Hypothalamus4.95
Kidney3.7
Leukemia_chronicMyelogenousK-5624.05
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.6
Liver6.15
Lung4.9
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.3
MedullaOblongata4.85
OccipitalLobe4.05
OlfactoryBulb3.5
Ovary3.05
Pancreas3.7
PancreaticIslet4.8
ParietalLobe4.8
Pituitary5.3
Placenta34.6
Pons4.45
PrefrontalCortex5.5
Prostate5.25
Salivarygland3.95
SkeletalMuscle6.25
Skin8.65
SmoothMuscle5.1
Spinalcord4.7
SubthalamicNucleus4.15
SuperiorCervicalGanglion5.45
TemporalLobe4.2
Testis3.9
TestisGermCell3.65
TestisIntersitial3.75
TestisLeydigCell4.5
TestisSeminiferousTubule3.85
Thalamus5
Thymus5.1
Thyroid5.55
Tongue889.2
Tonsil73.75
Trachea16.2
TrigeminalGanglion8.15
Uterus3.6
UterusCorpus4
WholeBlood4.85
Wholebrain3.65
colon4.5
pineal_day5.36
pineal_night5.2
retina5.275
small_intestine4.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9142_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.16 ± 0.95
Basal Forebrain1.69 ± 0.2
Basal Part of Pons1.31 ± 0.42
Cerebellar Cortex1.58 ± 0.65
Cerebellar Nuclei2 ± 0.73
Claustrum2.61 ± 0.85
Epithalamus1.42 ± 0.77
Frontal Lobe1.76 ± 0.82
Globus Pallidus2.14 ± 0.49
Hypothalamus1.85 ± 0.61
Insula1.89 ± 0.79
Limbic Lobe1.74 ± 0.67
Mesencephalon1.94 ± 0.68
Myelencephalon1.83 ± 0.65
Occipital Lobe1.79 ± 0.66
Parietal Lobe1.89 ± 0.79
Pontine Tegmentum1.82 ± 0.78
Striatum1.81 ± 0.55
Subthalamus1.92 ± 0.68
Temporal Lobe1.57 ± 0.66
Thalamus1.76 ± 0.6
White Matter1.9 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Krt6aCBCerebellum3.29
4.98
Krt6aCTXCerebral cortex0.77
1.28
Krt6aHIPHippocampal region0.37
0.5
Krt6aHPFHippocampal formation0.32
0.5
Krt6aHYHypothalamus0.06
0.11
Krt6aLSXLateral septal complex0.06
0.09
Krt6aMBMidbrain0.24
0.36
Krt6aMYMedulla0.67
0.83
Krt6aOLFOlfactory bulb1.44
2.56
Krt6aPPons0.16
0.31
Krt6aPALPallidum0.08
0.29
Krt6aRHPRetrohippocampal region0.25
0.51
Krt6asAMYStriatum-like amygdalar nuclei0.13
0.17
Krt6aSTRStriatum0.11
0.11
Krt6aSTRdStriatum dorsal region0.12
0.1
Krt6aSTRvStriatum ventral region0.1
0.14
Krt6aTHThalamus0.32
0.46
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
K2C6A_HUMAN_1 8 1 8 ASTSTTIR PRIDE
K2C6A_HUMAN_173 7 173 179 FASFIDK PRIDE
K2C6A_HUMAN_232 8 232 239 GRLDSELR PRIDE
K2C6A_HUMAN_326 12 326 337 NLDLDSIIAEVK PRIDE
K2C6A_HUMAN_338 9 338 346 AQYEEIAQR PRIDE
K2C6A_HUMAN_40 19 40 58 SRGSGGLGGACGGAGFGSR PRIDE
K2C6A_HUMAN_42 17 42 58 GSGGLGGACGGAGFGSR PRIDE
K2C6A_HUMAN_533 17 533 549 AIGGGLSSVGGGSSTIK PRIDE
K2C6A_HUMAN_59 10 59 68 SLYGLGGSKR PRIDE
K2C6A_HUMAN_59 9 59 67 SLYGLGGSK PRIDE
K2C6A_HUMAN_69 17 69 85 ISIGGGSCAISGGYGSR PRIDE
PAp00003103 17 43 59 GSGGLGGACGGAGFGSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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