AutismKB 2.0

Annotation Detail for KRT16


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Basic Information Top
Gene Symbol:KRT16 ( CK16,FNEPPK,K16,K1CP,KRT16A,NEPPK )
Gene Full Name: keratin 16
Band: 17q21.2
Quick LinksEntrez ID:3868; OMIM: 148067; Uniprot ID:K1C16_HUMAN; ENSEMBL ID: ENSG00000186832; HGNC ID: 6423
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult127 / 193912165
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma16 / 17475915
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor67 / 172903875
gastrointestinal tumor5 / 11936941
germ cell tumor0 / 2638450 
glioma20 / 106883187
head and neck tumor80 / 136302586
kidney tumor1 / 6895914
leukemia9 / 9584293
liver tumor0 / 963590 
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal56 / 336030716
ovarian tumor6 / 7668278
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor137 / 1249491096
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites4 / 4001599
bladder16 / 29757537
blood9 / 12347872
bone0 / 716550 
bone marrow0 / 488010 
brain20 / 110098918
cervix6 / 48171124
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus71 / 202093513
eye0 / 2110540 
heart0 / 896260 
intestine2 / 2344728
kidney1 / 2117774
larynx26 / 241451076
liver0 / 2077430 
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland17 / 153271110
mouth47 / 67052700
muscle3 / 10771527
nerve0 / 157680 
ovary6 / 10205158
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx14 / 41328338
pituitary gland0 / 165850 
placenta2 / 2808257
prostate9 / 18934547
salivary gland0 / 201550 
skin151 / 210574717
spleen0 / 539520 
stomach1 / 9661910
testis0 / 3304420 
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209800_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.8
Adipocyte5.4
AdrenalCortex6.1
Adrenalgland4.6
Amygdala5.75
Appendix5.6
AtrioventricularNode4.5
BDCA4+_DentriticCells5.65
Bonemarrow5.45
BronchialEpithelialCells282.85
CD105+_Endothelial5.65
CD14+_Monocytes5.85
CD19+_BCells(neg._sel.)5.8
CD33+_Myeloid7
CD34+7.35
CD4+_Tcells6.05
CD56+_NKCells6.65
CD71+_EarlyErythroid5.2
CD8+_Tcells5.35
CardiacMyocytes7.45
Caudatenucleus4.95
Cerebellum4.4
CerebellumPeduncles6.25
CiliaryGanglion4.25
CingulateCortex5.6
Colorectaladenocarcinoma5.45
DorsalRootGanglion4.4
FetalThyroid5.3
Fetalbrain5.4
Fetalliver4.8
Fetallung4.3
GlobusPallidus4
Heart7.6
Hypothalamus5.9
Kidney4.5
Leukemia_chronicMyelogenousK-5624.9
Leukemia_promyelocytic-HL-604.8
Leukemialymphoblastic(MOLT-4)4.4
Liver7.75
Lung6
Lymphnode4.6
Lymphoma_burkitts(Daudi)7
Lymphoma_burkitts(Raji)8
MedullaOblongata4.95
OccipitalLobe4.85
OlfactoryBulb4.3
Ovary3.65
Pancreas4.4
PancreaticIslet5.85
ParietalLobe5.75
Pituitary6.4
Placenta5.55
Pons5.2
PrefrontalCortex6.9
Prostate6.4
Salivarygland4.55
SkeletalMuscle6.75
Skin4.7
SmoothMuscle6.2
Spinalcord5.75
SubthalamicNucleus5.05
SuperiorCervicalGanglion6.35
TemporalLobe5.05
Testis4.7
TestisGermCell4.6
TestisIntersitial4.65
TestisLeydigCell5.45
TestisSeminiferousTubule4.7
Thalamus5.6
Thymus4.35
Thyroid6.8
Tongue1527.15
Tonsil25.3
Trachea4.55
TrigeminalGanglion5.9
Uterus4.5
UterusCorpus5.1
WholeBlood5.85
Wholebrain4.5
colon5.55
pineal_day6.84
pineal_night6.74
retina6.7
small_intestine5.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P38537
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.16 ± 1.19
Basal Forebrain1.49 ± 0.33
Basal Part of Pons1.41 ± 0.67
Cerebellar Cortex1.6 ± 0.92
Cerebellar Nuclei2.83 ± 0.83
Claustrum2.43 ± 0.93
Epithalamus1.17 ± 0.84
Frontal Lobe1.55 ± 0.78
Globus Pallidus2.54 ± 0.69
Hypothalamus1.56 ± 0.65
Insula1.44 ± 0.57
Limbic Lobe1.6 ± 0.87
Mesencephalon1.77 ± 0.9
Myelencephalon1.69 ± 0.82
Occipital Lobe1.56 ± 0.84
Parietal Lobe1.56 ± 0.95
Pontine Tegmentum1.6 ± 0.71
Striatum1.68 ± 0.78
Subthalamus1.41 ± 0.72
Temporal Lobe1.57 ± 0.84
Thalamus1.57 ± 0.7
White Matter1.93 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Krt16CBCerebellum1.79
2.95
Krt16CTXCerebral cortex0.96
1.18
Krt16HIPHippocampal region3.66
6.61
Krt16HPFHippocampal formation2.55
4
Krt16HYHypothalamus0.04
0.03
Krt16LSXLateral septal complex0.06
0
Krt16MBMidbrain1.59
2.23
Krt16MYMedulla0.49
0.89
Krt16OLFOlfactory bulb0.43
0.32
Krt16PPons5.45
7.49
Krt16PALPallidum0.24
0.21
Krt16RHPRetrohippocampal region1.1
0.8
Krt16sAMYStriatum-like amygdalar nuclei0.08
0.11
Krt16STRStriatum0.13
0.23
Krt16STRdStriatum dorsal region0.09
0.18
Krt16STRvStriatum ventral region0.34
0.48
Krt16THThalamus0.12
0.23
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
K1C16_HUMAN_453 20 453 472 QTRPILKEQSSSSFSQGQSS PRIDE
PAp00003093 15 16 30 GSCGIGGGIGGGSSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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