AutismKB 2.0

Annotation Detail for KRT18


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Basic Information Top
Gene Symbol:KRT18 ( CYK18,K18 )
Gene Full Name: keratin 18
Band: 12q13.13
Quick LinksEntrez ID:3875; OMIM: 148070; Uniprot ID:K1C18_HUMAN; ENSEMBL ID: ENSG00000111057; HGNC ID: 6430
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body146 / 707612063
blastocyst54 / 62319866
fetus42 / 56401274
neonate4 / 31097128
infant0 / 236200 
juvenile1 / 5555617
adult1152 / 1939121594
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor285 / 941783026
cervical tumor25 / 34366727
chondrosarcoma5 / 8282360
colorectal tumor519 / 1142464542
esophageal tumor74 / 172904279
gastrointestinal tumor112 / 119369938
germ cell tumor246 / 263845932
glioma9 / 10688384
head and neck tumor28 / 136302205
kidney tumor36 / 68959522
leukemia20 / 95842208
liver tumor158 / 963591639
lung tumor163 / 1031271580
lymphoma3 / 7175541
non-neoplasia12 / 97250123
normal826 / 3360307245
ovarian tumor105 / 766821369
pancreatic tumor486 / 1046164645
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer127 / 1026801236
retinoblastoma4 / 4635686
skin tumor64 / 124949512
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor174 / 902571927
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland0 / 331970 
ascites55 / 400151374
bladder10 / 29757336
blood6 / 12347848
bone8 / 71655111
bone marrow19 / 48801389
brain19 / 110098917
cervix32 / 48171664
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue254 / 2157221177
esophagus74 / 202093661
eye97 / 211054459
heart9 / 89626100
intestine562 / 2344722396
kidney61 / 211777288
larynx9 / 24145372
liver197 / 207743948
lung204 / 336974605
lymph3 / 4427067
lymph node7 / 9161076
mammary gland293 / 1532711911
mouth5 / 6705274
muscle1 / 1077159
nerve0 / 157680 
ovary117 / 1020511146
pancreas504 / 2148122346
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland8 / 16585482
placenta409 / 2808251456
prostate156 / 189345823
salivary gland1 / 2015549
skin70 / 210574332
spleen3 / 5395255
stomach73 / 96619755
testis11 / 33044233
thymus0 / 811310 
thyroid24 / 47473505
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord4 / 13680292
uterus181 / 232878777
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201596_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.4
Adipocyte3.6
AdrenalCortex3.8
Adrenalgland3.2
Amygdala3.85
Appendix3.65
AtrioventricularNode2.7
BDCA4+_DentriticCells3.9
Bonemarrow3.5
BronchialEpithelialCells1390.25
CD105+_Endothelial3.7
CD14+_Monocytes3.85
CD19+_BCells(neg._sel.)3.9
CD33+_Myeloid4.65
CD34+4.7
CD4+_Tcells4
CD56+_NKCells4.35
CD71+_EarlyErythroid3.35
CD8+_Tcells3.6
CardiacMyocytes1254
Caudatenucleus3.25
Cerebellum2.95
CerebellumPeduncles4.1
CiliaryGanglion2.5
CingulateCortex3.65
Colorectaladenocarcinoma9730.55
DorsalRootGanglion2.75
FetalThyroid563.05
Fetalbrain3.65
Fetalliver177.9
Fetallung655.4
GlobusPallidus2.6
Heart4.55
Hypothalamus4.1
Kidney87.85
Leukemia_chronicMyelogenousK-562474.9
Leukemia_promyelocytic-HL-603.2
Leukemialymphoblastic(MOLT-4)2.9
Liver1945.65
Lung1030.8
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.6
Lymphoma_burkitts(Raji)5
MedullaOblongata3.25
OccipitalLobe3.25
OlfactoryBulb2.85
Ovary2.4
Pancreas3068.9
PancreaticIslet903.3
ParietalLobe3.75
Pituitary225.45
Placenta4477.3
Pons3.45
PrefrontalCortex4.45
Prostate1566.65
Salivarygland349.9
SkeletalMuscle4.05
Skin19.7
SmoothMuscle305.5
Spinalcord3.85
SubthalamicNucleus3.25
SuperiorCervicalGanglion4.05
TemporalLobe3.3
Testis10.65
TestisGermCell8.15
TestisIntersitial4.8
TestisLeydigCell6.25
TestisSeminiferousTubule3.8
Thalamus3.65
Thymus8.55
Thyroid957.65
Tongue14.85
Tonsil9.95
Trachea419.85
TrigeminalGanglion3.6
Uterus26.85
UterusCorpus3.25
WholeBlood3.9
Wholebrain3.1
colon1869.05
pineal_day4.5
pineal_night4.44
retina82.225
small_intestine1282.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P924957
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.91 ± 0.84
Basal Forebrain2.46 ± 0.63
Basal Part of Pons3.16 ± 0.48
Cerebellar Cortex3.1 ± 0.45
Cerebellar Nuclei2.78 ± 0.7
Claustrum3.05 ± 0.76
Epithalamus2.31 ± 0.92
Frontal Lobe2.37 ± 0.68
Globus Pallidus2.89 ± 0.62
Hypothalamus2.78 ± 0.55
Insula2.22 ± 0.66
Limbic Lobe2.62 ± 0.7
Mesencephalon2.72 ± 0.83
Myelencephalon2.59 ± 0.73
Occipital Lobe3 ± 0.79
Parietal Lobe2.51 ± 0.77
Pontine Tegmentum2.61 ± 0.68
Striatum2.6 ± 0.84
Subthalamus2.56 ± 0.76
Temporal Lobe2.53 ± 0.69
Thalamus2.48 ± 0.7
White Matter3.24 ± 1.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Krt18CBCerebellum0
0
Krt18CTXCerebral cortex0
0
Krt18HIPHippocampal region0
0
Krt18HPFHippocampal formation0
0
Krt18HYHypothalamus0
0
Krt18LSXLateral septal complex0
0
Krt18MBMidbrain0
0
Krt18MYMedulla0
0
Krt18OLFOlfactory bulb0
0
Krt18PPons0
0
Krt18PALPallidum0
0
Krt18RHPRetrohippocampal region0
0
Krt18sAMYStriatum-like amygdalar nuclei0
0
Krt18STRStriatum0
0
Krt18STRdStriatum dorsal region0
0
Krt18STRvStriatum ventral region0
0
Krt18THThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
K1C18_HUMAN_137 12 137 148 AQIFANTVDNAR PRIDE
K1C18_HUMAN_138 11 138 148 QIFANTVDNAR PRIDE
K1C18_HUMAN_14 13 14 26 SLGSVQAPSYGAR PRIDE
K1C18_HUMAN_149 9 149 157 IVLQIDNAR PRIDE
K1C18_HUMAN_15 13 15 27 SLGSVQAPSYGAR PRIDE
K1C18_HUMAN_165 10 165 174 VKYETELAMR PRIDE
K1C18_HUMAN_17 10 17 26 SVQAPSYGAR PRIDE
K1C18_HUMAN_175 11 175 185 QSVENDIHGLR PRIDE
K1C18_HUMAN_186 10 186 195 KVIDDTNITR PRIDE
K1C18_HUMAN_187 9 187 195 VIDDTNITR PRIDE
K1C18_HUMAN_240 13 240 252 KSQDLAKIMADIR PRIDE
K1C18_HUMAN_242 11 242 252 QDLAKIMADIR PRIDE
K1C18_HUMAN_253 8 253 260 AQYDELAR PRIDE
K1C18_HUMAN_26 19 26 44 RPVSSAASVYAGAGGSGSR PRIDE
K1C18_HUMAN_27 18 27 44 PVSSAASVYAGAGGSGSR PRIDE
K1C18_HUMAN_28 17 28 44 VSSAASVYAGAGGSGSR PRIDE
K1C18_HUMAN_301 13 301 313 TVQSLEIDLDSMR PRIDE
K1C18_HUMAN_317 8 317 324 ASLENSLR PRIDE
K1C18_HUMAN_358 12 358 369 QAQEYEALLNIK PRIDE
K1C18_HUMAN_372 10 372 381 LEAEIATYRR PRIDE
K1C18_HUMAN_372 9 372 380 LEAEIATYR PRIDE
K1C18_HUMAN_373 8 373 380 EAEIATYR PRIDE
K1C18_HUMAN_55 26 55 80 GGMGSGGLATGIAGGLAGMGGIQNEK PRIDE
K1C18_HUMAN_91 6 91 96 ASYLDR PRIDE
PAp00008805 23 331 353 YALQMEQLNGILLHLESELAQTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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