AutismKB 2.0

Annotation Detail for PLEKHM3


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Basic Information Top
Gene Symbol:PLEKHM3 ( DAPR,DKFZp686O04200,FLJ41210,PLEKHM1L )
Gene Full Name: pleckstrin homology domain containing, family M, member 3
Band: 2q33.3
Quick LinksEntrez ID:389072; OMIM: NA; Uniprot ID:PKHM3_HUMAN; ENSEMBL ID: ENSG00000178385; HGNC ID: 34006
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult37 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal62 / 336030718
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow1 / 4880120
brain30 / 110098927
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine2 / 2344728
kidney5 / 21177723
larynx0 / 241450 
liver2 / 2077439
lung9 / 33697426
lymph0 / 442700 
lymph node3 / 9161032
mammary gland0 / 1532710 
mouth4 / 6705259
muscle4 / 10771537
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach2 / 9661920
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P171152
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8 ± 0.41
Basal Forebrain8.42 ± 0.22
Basal Part of Pons8.7 ± 0.19
Cerebellar Cortex8.26 ± 0.18
Cerebellar Nuclei8.56 ± 0.36
Claustrum8.43 ± 0.32
Epithalamus7.97 ± 0.4
Frontal Lobe8.46 ± 0.35
Globus Pallidus8 ± 0.45
Hypothalamus8.63 ± 0.24
Insula8.47 ± 0.31
Limbic Lobe8.47 ± 0.28
Mesencephalon8.38 ± 0.33
Myelencephalon8.35 ± 0.39
Occipital Lobe8.56 ± 0.26
Parietal Lobe8.53 ± 0.31
Pontine Tegmentum8.35 ± 0.34
Striatum7.83 ± 0.45
Subthalamus8.5 ± 0.05
Temporal Lobe8.47 ± 0.26
Thalamus8.37 ± 0.34
White Matter8.43 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
9430067K14RikLSXLateral septal complex8.75
6.55
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018