AutismKB 2.0

Annotation Detail for GFRAL


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Basic Information Top
Gene Symbol:GFRAL ( C6orf144,GRAL,UNQ9356,bA360D14.1 )
Gene Full Name: GDNF family receptor alpha like
Band: 6p12.1
Quick LinksEntrez ID:389400; OMIM: NA; Uniprot ID:GFRAL_HUMAN; ENSEMBL ID: ENSG00000187871; HGNC ID: 32789
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2125_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.3 ± 0.87
Basal Forebrain5.16 ± 0.62
Basal Part of Pons5.05 ± 0.49
Cerebellar Cortex4.58 ± 0.66
Cerebellar Nuclei5.58 ± 0.56
Claustrum5.51 ± 1
Epithalamus4.02 ± 1.05
Frontal Lobe5 ± 0.7
Globus Pallidus5.58 ± 0.43
Hypothalamus4.63 ± 0.85
Insula4.7 ± 1.29
Limbic Lobe5.13 ± 0.77
Mesencephalon5.2 ± 0.65
Myelencephalon5.14 ± 0.82
Occipital Lobe5.16 ± 0.86
Parietal Lobe4.96 ± 0.73
Pontine Tegmentum5.02 ± 0.76
Striatum5.56 ± 0.77
Subthalamus5.12 ± 0.32
Temporal Lobe4.92 ± 0.8
Thalamus5.37 ± 0.59
White Matter3.98 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GfralCBCerebellum7.82
10.26
GfralCTXCerebral cortex3.54
4.37
GfralHIPHippocampal region1.17
1.18
GfralHPFHippocampal formation0.91
0.9
GfralHYHypothalamus0.73
0.57
GfralLSXLateral septal complex0.4
0.27
GfralMBMidbrain2.89
2.87
GfralMYMedulla6.37
6.86
GfralOLFOlfactory bulb2.48
1.97
GfralPPons5.05
4.97
GfralPALPallidum0.17
0.11
GfralRHPRetrohippocampal region0.28
0.4
GfralsAMYStriatum-like amygdalar nuclei0.46
0.39
GfralSTRStriatum0.42
0.32
GfralSTRdStriatum dorsal region0.52
0.41
GfralSTRvStriatum ventral region0.19
0.09
GfralTHThalamus1.34
1.42
Peptide Top

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018