Annotation Detail for AFF3
Basic Information Top
| Gene Symbol: | AFF3 ( LAF4,MLLT2-like ) |
|---|---|
| Gene Full Name: | AF4/FMR2 family, member 3 |
| Band: | 2q11.2 |
| Quick Links | Entrez ID:3899; OMIM: 601464; Uniprot ID:AFF3_HUMAN; ENSEMBL ID: ENSG00000144218; HGNC ID: 6473 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.444414
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 94 / 564012 | 166 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 43 / 1939121 | 22 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 7 / 263845 | 26 | |
| glioma | 3 / 106883 | 28 | |
| head and neck tumor | 1 / 136302 | 7 |  |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 13 / 95842 | 135 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 1 / 71755 | 13 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 204 / 3360307 | 60 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 1 / 104616 | 9 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 5 / 102680 | 48 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 2 / 125191 | 15 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 3 / 123478 | 24 | |
| bone | 3 / 71655 | 41 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 92 / 1100989 | 83 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 3 / 149255 | 20 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 4 / 215722 | 18 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 9 / 211054 | 42 | |
| heart | 2 / 89626 | 22 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 4 / 211777 | 18 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 9 / 336974 | 26 | |
| lymph | 1 / 44270 | 22 | |
| lymph node | 35 / 91610 | 382 |  |
| mammary gland | 5 / 153271 | 32 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 11 / 280825 | 39 | |
| prostate | 5 / 189345 | 26 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 3 / 210574 | 14 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 1 / 96619 | 10 | |
| testis | 8 / 330442 | 24 | |
| thymus | 5 / 81131 | 61 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 2 / 52413 | 38 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 2 / 232878 | 8 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 205735_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 8.6 | |
| Adipocyte | 7.2 | |
| AdrenalCortex | 7.95 | |
| Adrenalgland | 6.3 | |
| Amygdala | 7.3 | |
| Appendix | 8.7 | |
| AtrioventricularNode | 6 | |
| BDCA4+_DentriticCells | 7.8 | |
| Bonemarrow | 7.2 | |
| BronchialEpithelialCells | 7.05 | |
| CD105+_Endothelial | 7.2 | |
| CD14+_Monocytes | 8.15 | |
| CD19+_BCells(neg._sel.) | 7.55 | |
| CD33+_Myeloid | 9.05 | |
| CD34+ | 8.85 | |
| CD4+_Tcells | 8 | |
| CD56+_NKCells | 8.3 | |
| CD71+_EarlyErythroid | 7.3 | |
| CD8+_Tcells | 6.7 | |
| CardiacMyocytes | 11.05 | |
| Caudatenucleus | 6.55 | |
| Cerebellum | 5.9 | |
| CerebellumPeduncles | 8.9 | |
| CiliaryGanglion | 5.6 | |
| CingulateCortex | 7.5 | |
| Colorectaladenocarcinoma | 7.25 | |
| DorsalRootGanglion | 5.95 | |
| FetalThyroid | 7.1 | |
| Fetalbrain | 7.3 | |
| Fetalliver | 6.4 | |
| Fetallung | 5.8 | |
| GlobusPallidus | 5.45 | |
| Heart | 10.05 | |
| Hypothalamus | 7.6 | |
| Kidney | 6.15 | |
| Leukemia_chronicMyelogenousK-562 | 6.6 | |
| Leukemia_promyelocytic-HL-60 | 6.4 | |
| Leukemialymphoblastic(MOLT-4) | 5.9 | |
| Liver | 10.05 | |
| Lung | 7.7 | |
| Lymphnode | 5.95 | |
| Lymphoma_burkitts(Daudi) | 9.35 | |
| Lymphoma_burkitts(Raji) | 11.55 | |
| MedullaOblongata | 6.7 | |
| OccipitalLobe | 6.15 | |
| OlfactoryBulb | 5.65 | |
| Ovary | 4.85 | |
| Pancreas | 6.55 | |
| PancreaticIslet | 8.1 | |
| ParietalLobe | 7.8 | |
| Pituitary | 8.5 | |
| Placenta | 7.15 | |
| Pons | 9.6 | |
| PrefrontalCortex | 8 | |
| Prostate | 8.35 | |
| Salivarygland | 5.9 | |
| SkeletalMuscle | 9.35 | |
| Skin | 5.9 | |
| SmoothMuscle | 8.15 | |
| Spinalcord | 7.75 | |
| SubthalamicNucleus | 6.75 | |
| SuperiorCervicalGanglion | 8.75 | |
| TemporalLobe | 6.7 | |
| Testis | 6.3 | |
| TestisGermCell | 6.05 | |
| TestisIntersitial | 6.3 | |
| TestisLeydigCell | 7.3 | |
| TestisSeminiferousTubule | 6.15 | |
| Thalamus | 7.4 | |
| Thymus | 5.55 | |
| Thyroid | 8.95 | |
| Tongue | 7.85 | |
| Tonsil | 7.1 | |
| Trachea | 6.05 | |
| TrigeminalGanglion | 12.4 | |
| Uterus | 5.85 | |
| UterusCorpus | 6.75 | |
| WholeBlood | 7.95 | |
| Wholebrain | 5.8 | |
| colon | 7.3 | |
| pineal_day | 8.92 | |
| pineal_night | 8.76 | |
| retina | 8.675 | |
| small_intestine | 6.85 | |
- Probe name: A_24_P366670
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.02 ± 0.72 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.22 ± 0.34 | |
| Basal Part of Pons | 5.87 ± 0.53 | |
| Cerebellar Cortex | 5.83 ± 0.34 | |
| Cerebellar Nuclei | 5.24 ± 0.39 | |
| Claustrum | 6.54 ± 0.74 | |
| Epithalamus | 4.83 ± 0.54 | |
| Frontal Lobe | 5.36 ± 0.55 | |
| Globus Pallidus | 4.87 ± 0.55 | |
| Hypothalamus | 4.92 ± 0.55 | |
| Insula | 5.26 ± 0.49 | |
| Limbic Lobe | 5.89 ± 0.63 | |
| Mesencephalon | 5.51 ± 0.67 | |
| Myelencephalon | 5.57 ± 0.64 | |
| Occipital Lobe | 5.62 ± 0.44 | |
| Parietal Lobe | 5.61 ± 0.62 | |
| Pontine Tegmentum | 5.36 ± 0.62 | |
| Striatum | 5.63 ± 0.8 | |
| Subthalamus | 5.69 ± 0.57 | |
| Temporal Lobe | 5.55 ± 0.61 | |
| Thalamus | 5.3 ± 0.51 | |
| White Matter | 4.17 ± 0.64 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Aff3 | CB | Cerebellum | 16.97 | |
| 19.07 | | |||
| Aff3 | CTX | Cerebral cortex | 54.77 | |
| 47.92 | | |||
| Aff3 | HIP | Hippocampal region | 43.82 | |
| 77.38 | | |||
| Aff3 | HPF | Hippocampal formation | 44.8 | |
| 61.49 | | |||
| Aff3 | HY | Hypothalamus | 29.92 | |
| 25.1 | | |||
| Aff3 | LSX | Lateral septal complex | 30.3 | |
| 27.37 | | |||
| Aff3 | MB | Midbrain | 26.93 | |
| 25.3 | | |||
| Aff3 | MY | Medulla | 47.08 | |
| 55.12 | | |||
| Aff3 | OLF | Olfactory bulb | 42.18 | |
| 34.11 | | |||
| Aff3 | P | Pons | 32.02 | |
| 36.17 | | |||
| Aff3 | PAL | Pallidum | 35.86 | |
| 37.3 | | |||
| Aff3 | RHP | Retrohippocampal region | 46.36 | |
| 40.12 | | |||
| Aff3 | sAMY | Striatum-like amygdalar nuclei | 29.73 | |
| 23.36 | | |||
| Aff3 | STR | Striatum | 67.06 | |
| 52.87 | | |||
| Aff3 | STRd | Striatum dorsal region | 88.77 | |
| 71.63 | | |||
| Aff3 | STRv | Striatum ventral region | 32.68 | |
| 22.14 | | |||
| Aff3 | TH | Thalamus | 33.29 | |
| 32.22 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| AFF3_HUMAN_709 | 20 | 709 | 728 | EAAANGGSGPRAPVGSINAR | PRIDE |