AutismKB 2.0

Annotation Detail for LAMB1


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Basic Information Top
Gene Symbol:LAMB1 ( CLM,MGC142015 )
Gene Full Name: laminin, beta 1
Band: 7q31.1
Quick LinksEntrez ID:3912; OMIM: 150240; Uniprot ID:LAMB1_HUMAN; ENSEMBL ID: ENSG00000091136; HGNC ID: 6486
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body29 / 70761409
blastocyst23 / 62319369
fetus76 / 564012134
neonate0 / 310970 
infant1 / 2362042
juvenile10 / 55556179
adult276 / 1939121142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor9 / 12794703
bladder carcinoma0 / 174750 
breast (mammary gland) tumor12 / 94178127
cervical tumor2 / 3436658
chondrosarcoma12 / 82823144
colorectal tumor21 / 114246183
esophageal tumor2 / 17290115
gastrointestinal tumor13 / 119369108
germ cell tumor24 / 26384590
glioma5 / 10688346
head and neck tumor29 / 136302212
kidney tumor50 / 68959725
leukemia2 / 9584220
liver tumor18 / 96359186
lung tumor8 / 10312777
lymphoma2 / 7175527
non-neoplasia7 / 9725071
normal358 / 3360307106
ovarian tumor9 / 76682117
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer0 / 1026800 
retinoblastoma8 / 46356172
skin tumor8 / 12494964
soft tissue/muscle tissue tumor15 / 125191119
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue11 / 13106839
adrenal gland9 / 33197271
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone5 / 7165569
bone marrow5 / 48801102
brain40 / 110098936
cervix2 / 4817141
connective tissue15 / 149255100
ear42 / 162122590
embryonic tissue73 / 215722338
esophagus2 / 2020998
eye22 / 211054104
heart11 / 89626122
intestine30 / 234472127
kidney71 / 211777335
larynx4 / 24145165
liver22 / 207743105
lung35 / 336974103
lymph1 / 4427022
lymph node2 / 9161021
mammary gland23 / 153271150
mouth15 / 67052223
muscle32 / 107715297
nerve8 / 15768507
ovary9 / 10205188
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta40 / 280825142
prostate5 / 18934526
salivary gland0 / 201550 
skin10 / 21057447
spleen1 / 5395218
stomach11 / 96619113
testis16 / 33044248
thymus4 / 8113149
thyroid10 / 47473210
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus27 / 232878115
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211651_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.8
Adipocyte837.05
AdrenalCortex14.95
Adrenalgland8.9
Amygdala9.65
Appendix14.65
AtrioventricularNode16.3
BDCA4+_DentriticCells8.1
Bonemarrow10.9
BronchialEpithelialCells144.25
CD105+_Endothelial8.8
CD14+_Monocytes10.15
CD19+_BCells(neg._sel.)8.55
CD33+_Myeloid10.8
CD34+11.05
CD4+_Tcells7.9
CD56+_NKCells9.45
CD71+_EarlyErythroid9.2
CD8+_Tcells7.45
CardiacMyocytes589.2
Caudatenucleus8.4
Cerebellum8.4
CerebellumPeduncles11.75
CiliaryGanglion12.75
CingulateCortex10.15
Colorectaladenocarcinoma16.05
DorsalRootGanglion18.25
FetalThyroid19.1
Fetalbrain11.6
Fetalliver19.4
Fetallung270
GlobusPallidus8.4
Heart19.35
Hypothalamus9.8
Kidney10.6
Leukemia_chronicMyelogenousK-5629.25
Leukemia_promyelocytic-HL-609.8
Leukemialymphoblastic(MOLT-4)7.1
Liver15.4
Lung10.9
Lymphnode15.45
Lymphoma_burkitts(Daudi)13.1
Lymphoma_burkitts(Raji)15.45
MedullaOblongata8.65
OccipitalLobe9.05
OlfactoryBulb108.65
Ovary8.55
Pancreas23.25
PancreaticIslet43.15
ParietalLobe11.4
Pituitary11.35
Placenta39.4
Pons9.55
PrefrontalCortex11.85
Prostate12.15
Salivarygland8
SkeletalMuscle14.95
Skin10
SmoothMuscle979.4
Spinalcord11.75
SubthalamicNucleus10.6
SuperiorCervicalGanglion15.75
TemporalLobe9.6
Testis8
TestisGermCell11.2
TestisIntersitial11
TestisLeydigCell10.15
TestisSeminiferousTubule8.4
Thalamus11.85
Thymus7.65
Thyroid45
Tongue11.2
Tonsil9.65
Trachea9.5
TrigeminalGanglion11.8
Uterus140.25
UterusCorpus29.75
WholeBlood10.05
Wholebrain7.6
colon32.9
pineal_day174.72
pineal_night283.4
retina12.4
small_intestine11.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17062_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.44 ± 0.63
Basal Forebrain6.21 ± 0.42
Basal Part of Pons5.99 ± 0.47
Cerebellar Cortex7.17 ± 0.23
Cerebellar Nuclei5.66 ± 0.44
Claustrum6.31 ± 0.38
Epithalamus5.71 ± 0.6
Frontal Lobe6.6 ± 0.71
Globus Pallidus4.31 ± 0.92
Hypothalamus5.47 ± 0.53
Insula7.04 ± 0.31
Limbic Lobe6.69 ± 0.85
Mesencephalon6.09 ± 0.82
Myelencephalon6.46 ± 0.66
Occipital Lobe6.13 ± 0.76
Parietal Lobe6.6 ± 0.59
Pontine Tegmentum6.65 ± 0.82
Striatum6.11 ± 0.49
Subthalamus5 ± 0.22
Temporal Lobe6.92 ± 0.47
Thalamus7.18 ± 0.55
White Matter3.97 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lamb1-1CBCerebellum19.61
22.55
Lamb1-1CTXCerebral cortex7.68
5.81
Lamb1-1HIPHippocampal region25.8
33
Lamb1-1HPFHippocampal formation21.9
23.83
Lamb1-1HYHypothalamus2.23
1.7
Lamb1-1LSXLateral septal complex4.37
3.48
Lamb1-1MBMidbrain3.73
3.18
Lamb1-1MYMedulla16.8
23.8
Lamb1-1OLFOlfactory bulb11.54
9.11
Lamb1-1PPons3.89
3.96
Lamb1-1PALPallidum2.77
2.2
Lamb1-1RHPRetrohippocampal region17.38
14.22
Lamb1-1sAMYStriatum-like amygdalar nuclei3.85
2.82
Lamb1-1STRStriatum10.85
8.56
Lamb1-1STRdStriatum dorsal region10.69
8.69
Lamb1-1STRvStriatum ventral region16.91
12.09
Lamb1-1THThalamus17.39
14.97
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LAMB1_HUMAN_1324 11 1324 1334 YFQMSLEAEER PRIDE
LAMB1_HUMAN_1531 18 1531 1548 MEMPSTPQQLQNLTEDIR PRIDE
LAMB1_HUMAN_198 11 198 208 EPSTEGEVIFR PRIDE
PAp00001199 14 1000 1013 CLYHTEGEHCQFCR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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