AutismKB 2.0

Annotation Detail for LAMB3


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Basic Information Top
Gene Symbol:LAMB3 ( BM600-125KDA,FLJ99565,LAM5,LAMNB1 )
Gene Full Name: laminin, beta 3
Band: 1q32.2
Quick LinksEntrez ID:3914; OMIM: 150310; Uniprot ID:LAMB3_HUMAN; ENSEMBL ID: ENSG00000196878; HGNC ID: 6490
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult119 / 193912161
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor21 / 114246183
esophageal tumor8 / 17290462
gastrointestinal tumor9 / 11936975
germ cell tumor0 / 2638450 
glioma4 / 10688337
head and neck tumor26 / 136302190
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor19 / 103127184
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal86 / 336030725
ovarian tumor6 / 7668278
pancreatic tumor20 / 104616191
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer12 / 102680116
retinoblastoma0 / 463560 
skin tumor30 / 124949240
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites5 / 40015124
bladder4 / 29757134
blood5 / 12347840
bone0 / 716550 
bone marrow0 / 488010 
brain7 / 11009896
cervix7 / 48171145
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus8 / 20209395
eye8 / 21105437
heart1 / 8962611
intestine27 / 234472115
kidney2 / 2117779
larynx4 / 24145165
liver5 / 20774324
lung39 / 336974115
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth23 / 67052343
muscle1 / 1077159
nerve0 / 157680 
ovary6 / 10205158
pancreas26 / 214812121
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta11 / 28082539
prostate16 / 18934584
salivary gland0 / 201550 
skin38 / 210574180
spleen0 / 539520 
stomach14 / 96619144
testis0 / 3304420 
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus15 / 23287864
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209270_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.4
Adipocyte4.55
AdrenalCortex4.9
Adrenalgland3.85
Amygdala4.7
Appendix4.6
AtrioventricularNode3.5
BDCA4+_DentriticCells4.85
Bonemarrow4.6
BronchialEpithelialCells2126.4
CD105+_Endothelial4.6
CD14+_Monocytes4.9
CD19+_BCells(neg._sel.)4.75
CD33+_Myeloid5.95
CD34+5.6
CD4+_Tcells4.95
CD56+_NKCells5.3
CD71+_EarlyErythroid4.25
CD8+_Tcells4.4
CardiacMyocytes6.05
Caudatenucleus4.1
Cerebellum3.65
CerebellumPeduncles5.1
CiliaryGanglion3.3
CingulateCortex4.6
Colorectaladenocarcinoma84.55
DorsalRootGanglion3.55
FetalThyroid4.4
Fetalbrain4.55
Fetalliver3.95
Fetallung22.5
GlobusPallidus3.35
Heart6.05
Hypothalamus5
Kidney3.75
Leukemia_chronicMyelogenousK-5624.1
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.65
Liver6.2
Lung70.1
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.5
MedullaOblongata4.1
OccipitalLobe4.1
OlfactoryBulb3.55
Ovary3.05
Pancreas5.35
PancreaticIslet13.95
ParietalLobe4.75
Pituitary5.3
Placenta7.15
Pons4.3
PrefrontalCortex5.55
Prostate8.65
Salivarygland4.3
SkeletalMuscle5.4
Skin4.25
SmoothMuscle5.7
Spinalcord4.8
SubthalamicNucleus4.15
SuperiorCervicalGanglion5.2
TemporalLobe4.15
Testis3.85
TestisGermCell3.75
TestisIntersitial3.75
TestisLeydigCell4.5
TestisSeminiferousTubule3.85
Thalamus4.55
Thymus3.65
Thyroid5.75
Tongue4.75
Tonsil4.45
Trachea4.95
TrigeminalGanglion4.65
Uterus3.65
UterusCorpus4.05
WholeBlood4.95
Wholebrain3.9
colon4.6
pineal_day5.62
pineal_night5.56
retina5.5
small_intestine4.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12864_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4 ± 0.92
Basal Forebrain4.04 ± 0.65
Basal Part of Pons3.72 ± 0.72
Cerebellar Cortex3.43 ± 0.59
Cerebellar Nuclei3.94 ± 0.72
Claustrum4.35 ± 1.05
Epithalamus3.77 ± 0.71
Frontal Lobe4.25 ± 0.62
Globus Pallidus3.04 ± 1.11
Hypothalamus4 ± 0.54
Insula4.54 ± 0.25
Limbic Lobe3.84 ± 0.73
Mesencephalon4.05 ± 0.65
Myelencephalon3.98 ± 0.66
Occipital Lobe3.19 ± 1.05
Parietal Lobe4.21 ± 0.74
Pontine Tegmentum4.11 ± 0.82
Striatum3.69 ± 0.97
Subthalamus3.84 ± 0.86
Temporal Lobe4.35 ± 0.57
Thalamus3.68 ± 0.73
White Matter2.96 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lamb3CBCerebellum9.56
11.46
Lamb3CTXCerebral cortex28.7
15.06
Lamb3HIPHippocampal region16.72
14.64
Lamb3HPFHippocampal formation18.68
14.2
Lamb3HYHypothalamus6.17
2.73
Lamb3LSXLateral septal complex0.28
0.25
Lamb3MBMidbrain1.87
1.4
Lamb3MYMedulla12.48
10.04
Lamb3OLFOlfactory bulb14.41
8.03
Lamb3PPons4.72
3.1
Lamb3PALPallidum13.67
6.98
Lamb3RHPRetrohippocampal region24
14.4
Lamb3sAMYStriatum-like amygdalar nuclei26.37
9.71
Lamb3STRStriatum11.59
4.64
Lamb3STRdStriatum dorsal region11.51
4.58
Lamb3STRvStriatum ventral region11.37
4.79
Lamb3THThalamus12.12
5.41
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LAMB3_HUMAN_207 11 207 217 IQEVGEITNLR PRIDE
LAMB3_HUMAN_635 24 635 658 AVLSSPAVTEQEVAQVASAILSLR PRIDE
LAMB3_HUMAN_635 25 635 659 AVLSSPAVTEQEVAQVASAILSLRR PRIDE
LAMB3_HUMAN_660 20 660 679 TLQGLQLDLPLEEETLSLPR PRIDE
LAMB3_HUMAN_824 16 824 839 AGGAFLMAGQVAEQLR PRIDE
LAMB3_HUMAN_941 12 941 952 LPNVDLVLSQTK PRIDE
PAp00096493 13 246 258 LQGSCFCHGHADR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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