AutismKB 2.0

Annotation Detail for LAMC2


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Basic Information Top
Gene Symbol:LAMC2 ( B2T,BM600,CSF,EBR2,EBR2A,LAMB2T,LAMNB2,MGC138491,MGC141938 )
Gene Full Name: laminin, gamma 2
Band: 1q25.3
Quick LinksEntrez ID:3918; OMIM: 150292; Uniprot ID:LAMC2_HUMAN; ENSEMBL ID: ENSG00000058085; HGNC ID: 6493
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult185 / 193912195
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma10 / 17475572
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor10 / 11424687
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor85 / 136302623
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal116 / 336030734
ovarian tumor4 / 7668252
pancreatic tumor32 / 104616305
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor18 / 124949144
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder10 / 29757336
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine16 / 23447268
kidney6 / 21177728
larynx9 / 24145372
liver2 / 2077439
lung24 / 33697471
lymph0 / 442700 
lymph node2 / 9161021
mammary gland27 / 153271176
mouth20 / 67052298
muscle4 / 10771537
nerve1 / 1576863
ovary4 / 10205139
pancreas46 / 214812214
parathyroid0 / 205390 
pharynx55 / 413281330
pituitary gland0 / 165850 
placenta3 / 28082510
prostate8 / 18934542
salivary gland0 / 201550 
skin41 / 210574194
spleen0 / 539520 
stomach17 / 96619175
testis0 / 3304420 
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus15 / 23287864
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207517_at
Cell line Expression level Expression bar
721_B_lymphoblasts13
Adipocyte11.55
AdrenalCortex16.5
Adrenalgland10.75
Amygdala11.85
Appendix18.5
AtrioventricularNode15.2
BDCA4+_DentriticCells11.2
Bonemarrow13.8
BronchialEpithelialCells295.3
CD105+_Endothelial12.1
CD14+_Monocytes12.55
CD19+_BCells(neg._sel.)12.5
CD33+_Myeloid14.3
CD34+13.95
CD4+_Tcells12.3
CD56+_NKCells13.05
CD71+_EarlyErythroid11.75
CD8+_Tcells10.15
CardiacMyocytes25.2
Caudatenucleus10.65
Cerebellum9.9
CerebellumPeduncles15.3
CiliaryGanglion11.95
CingulateCortex12.8
Colorectaladenocarcinoma12.2
DorsalRootGanglion14.15
FetalThyroid12.65
Fetalbrain11.4
Fetalliver10.8
Fetallung9.15
GlobusPallidus10
Heart27.2
Hypothalamus11.85
Kidney11.45
Leukemia_chronicMyelogenousK-56210.15
Leukemia_promyelocytic-HL-6010
Leukemialymphoblastic(MOLT-4)9.15
Liver19.5
Lung12.95
Lymphnode9.45
Lymphoma_burkitts(Daudi)16.45
Lymphoma_burkitts(Raji)19.55
MedullaOblongata10.05
OccipitalLobe10.55
OlfactoryBulb9.2
Ovary9.3
Pancreas12.25
PancreaticIslet13.5
ParietalLobe15.05
Pituitary13.9
Placenta11.8
Pons12.85
PrefrontalCortex13.8
Prostate13.1
Salivarygland10.75
SkeletalMuscle23.55
Skin14.7
SmoothMuscle13.6
Spinalcord12.45
SubthalamicNucleus12
SuperiorCervicalGanglion20.65
TemporalLobe11.85
Testis9.85
TestisGermCell9.8
TestisIntersitial10.2
TestisLeydigCell12.8
TestisSeminiferousTubule11.65
Thalamus12.6
Thymus9.1
Thyroid13.65
Tongue15.7
Tonsil14.15
Trachea9.85
TrigeminalGanglion20.35
Uterus9.05
UterusCorpus12.25
WholeBlood12.9
Wholebrain9
colon12.1
pineal_day14.74
pineal_night14.16
retina14.45
small_intestine11.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P201636
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.78 ± 0.54
Basal Forebrain4.49 ± 0.43
Basal Part of Pons4.44 ± 0.58
Cerebellar Cortex5.2 ± 0.45
Cerebellar Nuclei4.59 ± 0.51
Claustrum4.99 ± 0.78
Epithalamus3.93 ± 0.62
Frontal Lobe4.43 ± 0.68
Globus Pallidus4.45 ± 0.73
Hypothalamus4.14 ± 0.83
Insula4.5 ± 0.62
Limbic Lobe4.77 ± 0.71
Mesencephalon4.62 ± 0.57
Myelencephalon4.61 ± 0.72
Occipital Lobe4.44 ± 0.79
Parietal Lobe4.47 ± 0.67
Pontine Tegmentum4.41 ± 0.61
Striatum4.66 ± 0.81
Subthalamus4.54 ± 0.69
Temporal Lobe4.4 ± 0.61
Thalamus4.56 ± 0.62
White Matter4.35 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lamc2CBCerebellum1.22
1.86
Lamc2CTXCerebral cortex10.95
8.29
Lamc2HIPHippocampal region0.7
0.94
Lamc2HPFHippocampal formation2.62
2.54
Lamc2HYHypothalamus0.14
0.21
Lamc2LSXLateral septal complex0.08
0.06
Lamc2MBMidbrain0.61
0.86
Lamc2MYMedulla0.81
0.93
Lamc2OLFOlfactory bulb9.74
8.35
Lamc2PPons0.32
0.47
Lamc2PALPallidum0.06
0.05
Lamc2RHPRetrohippocampal region5.89
4.83
Lamc2sAMYStriatum-like amygdalar nuclei0.11
0.6
Lamc2STRStriatum0.22
0.3
Lamc2STRdStriatum dorsal region0.25
0.35
Lamc2STRvStriatum ventral region0.23
0.16
Lamc2THThalamus0.69
0.71
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LAMC2_HUMAN_1153 18 1153 1170 GHLHLLETSIDGILADVK PRIDE
LAMC2_HUMAN_622 8 622 629 QFMQQLQR PRIDE
LAMC2_HUMAN_652 13 652 664 MQQAEQALQDILR PRIDE
LAMC2_HUMAN_763 17 763 779 LAESHVESASNMEQLTR PRIDE
LAMC2_HUMAN_794 28 794 821 KALHEGVGSGSGSPDGAVVQGLVEKLEK PRIDE
LAMC2_HUMAN_995 12 995 1006 RALGSAAADAQR PRIDE
PAp00095462 14 541 554 CIHNTAGIYCDQCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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