AutismKB 2.0

Annotation Detail for ARHGAP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARHGAP1 ( CDC42GAP,RHOGAP,RHOGAP1,p50rhoGAP )
Gene Full Name: Rho GTPase activating protein 1
Band: 11p11.2
Quick LinksEntrez ID:392; OMIM: 602732; Uniprot ID:RHG01_HUMAN; ENSEMBL ID: ENSG00000175220; HGNC ID: 673
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst4 / 6231964
fetus14 / 56401224
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult89 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor3 / 3436687
chondrosarcoma18 / 82823217
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor14 / 26384553
glioma14 / 106883130
head and neck tumor8 / 13630258
kidney tumor6 / 6895987
leukemia7 / 9584273
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma3 / 7175541
non-neoplasia7 / 9725071
normal113 / 336030733
ovarian tumor2 / 7668226
pancreatic tumor24 / 104616229
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor9 / 12494972
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone4 / 7165555
bone marrow3 / 4880161
brain45 / 110098940
cervix3 / 4817162
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus2 / 2020998
eye10 / 21105447
heart8 / 8962689
intestine6 / 23447225
kidney18 / 21177784
larynx1 / 2414541
liver0 / 2077430 
lung20 / 33697459
lymph1 / 4427022
lymph node3 / 9161032
mammary gland4 / 15327126
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary5 / 10205148
pancreas34 / 214812158
parathyroid1 / 2053948
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta9 / 28082532
prostate6 / 18934531
salivary gland1 / 2015549
skin13 / 21057461
spleen3 / 5395255
stomach7 / 9661972
testis10 / 33044230
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus15 / 23287864
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216689_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.9
Adipocyte3.4
AdrenalCortex3
Adrenalgland2.5
Amygdala3.6
Appendix3
AtrioventricularNode2.2
BDCA4+_DentriticCells4.9
Bonemarrow3
BronchialEpithelialCells2.95
CD105+_Endothelial3.05
CD14+_Monocytes3.85
CD19+_BCells(neg._sel.)3.25
CD33+_Myeloid3.95
CD34+4.05
CD4+_Tcells3.35
CD56+_NKCells4
CD71+_EarlyErythroid2.8
CD8+_Tcells3.4
CardiacMyocytes4.55
Caudatenucleus2.85
Cerebellum2.4
CerebellumPeduncles3.4
CiliaryGanglion2.05
CingulateCortex3
Colorectaladenocarcinoma5.1
DorsalRootGanglion2.25
FetalThyroid3.35
Fetalbrain3.05
Fetalliver3.5
Fetallung2.9
GlobusPallidus2.1
Heart5.4
Hypothalamus3.35
Kidney2.4
Leukemia_chronicMyelogenousK-5622.75
Leukemia_promyelocytic-HL-602.8
Leukemialymphoblastic(MOLT-4)2.45
Liver6.6
Lung3.55
Lymphnode2.6
Lymphoma_burkitts(Daudi)3.8
Lymphoma_burkitts(Raji)4.1
MedullaOblongata2.75
OccipitalLobe2.75
OlfactoryBulb2.35
Ovary3
Pancreas2.4
PancreaticIslet3.25
ParietalLobe3.1
Pituitary4
Placenta3.95
Pons2.85
PrefrontalCortex3.8
Prostate3.7
Salivarygland2.4
SkeletalMuscle3.3
Skin2.25
SmoothMuscle5
Spinalcord3.2
SubthalamicNucleus2.65
SuperiorCervicalGanglion3.3
TemporalLobe2.65
Testis2.85
TestisGermCell2.65
TestisIntersitial2.5
TestisLeydigCell2.95
TestisSeminiferousTubule2.6
Thalamus3
Thymus2.4
Thyroid4.85
Tongue3.05
Tonsil3.05
Trachea3.1
TrigeminalGanglion2.85
Uterus3.75
UterusCorpus2.7
WholeBlood5.7
Wholebrain2.65
colon3.55
pineal_day3.78
pineal_night3.68
retina3.7
small_intestine2.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P44057
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.19 ± 0.82
Basal Forebrain4.14 ± 0.56
Basal Part of Pons3.96 ± 0.44
Cerebellar Cortex3.84 ± 0.56
Cerebellar Nuclei3.76 ± 0.37
Claustrum4 ± 0.73
Epithalamus3.89 ± 0.64
Frontal Lobe4.23 ± 0.56
Globus Pallidus4.56 ± 0.61
Hypothalamus3.92 ± 0.59
Insula4.12 ± 0.25
Limbic Lobe4.18 ± 0.58
Mesencephalon4.04 ± 0.72
Myelencephalon4.24 ± 0.64
Occipital Lobe3.83 ± 0.66
Parietal Lobe4.18 ± 0.62
Pontine Tegmentum4.21 ± 0.58
Striatum4.44 ± 0.56
Subthalamus4.02 ± 0.23
Temporal Lobe4.15 ± 0.51
Thalamus4.09 ± 0.61
White Matter5.65 ± 0.44
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arhgap1CBCerebellum6.99
6.79
Arhgap1CTXCerebral cortex40.27
30.47
Arhgap1HIPHippocampal region17.74
17.35
Arhgap1HPFHippocampal formation21.64
19.16
Arhgap1HYHypothalamus9.84
7.06
Arhgap1LSXLateral septal complex28.94
21.08
Arhgap1MBMidbrain5.98
5.04
Arhgap1MYMedulla10.01
10.5
Arhgap1OLFOlfactory bulb27.13
21.83
Arhgap1PPons9.01
8.27
Arhgap1PALPallidum8.51
7.01
Arhgap1RHPRetrohippocampal region29.55
22.7
Arhgap1sAMYStriatum-like amygdalar nuclei35.41
25.19
Arhgap1STRStriatum12.6
8.69
Arhgap1STRdStriatum dorsal region8.35
5.83
Arhgap1STRvStriatum ventral region9.47
5.65
Arhgap1THThalamus11.67
8.56
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069725 14 70 83 HQIVEVAGDDKYGR Peptide Atlas
RHG01_HUMAN_109 32 109 140 HTLDQYVESDYTLLYLHHGLTSDNKPSLSWLR PRIDE
RHG01_HUMAN_168 13 168 180 TLLILFKPLISFK PRIDE
RHG01_HUMAN_200 8 200 207 LEQLGIPR PRIDE
RHG01_HUMAN_252 12 252 263 NPEQEPIPIVLR PRIDE
RHG01_HUMAN_264 19 264 282 ETVAYLQAHALTTEGIFRR PRIDE
RHG01_HUMAN_296 23 296 318 YNMGLPVDFDQYNELHLPAVILK PRIDE
RHG01_HUMAN_349 20 349 368 VPATLQVLQTLPEENYQVLR PRIDE
RHG01_HUMAN_421 18 421 438 FLLDHQGELFPSPDPSGL PRIDE
RHG01_HUMAN_59 10 59 68 WDDPYYDIAR PRIDE
RHG01_HUMAN_69 14 69 82 HQIVEVAGDDKYGR PRIDE
RHG01_HUMAN_69 15 69 83 HQIVEVAGDDKYGRK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved