AutismKB 2.0

Annotation Detail for LAMP2


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Basic Information Top
Gene Symbol:LAMP2 ( CD107b,LAMPB,LGP110 )
Gene Full Name: lysosomal-associated membrane protein 2
Band: Xq24
Quick LinksEntrez ID:3920; OMIM: 309060; Uniprot ID:LAMP2_HUMAN; ENSEMBL ID: ENSG00000005893; HGNC ID: 6501
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst9 / 62319144
fetus91 / 564012161
neonate8 / 31097257
infant0 / 236200 
juvenile12 / 55556215
adult422 / 1939121217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor13 / 94178138
cervical tumor2 / 3436658
chondrosarcoma16 / 82823193
colorectal tumor20 / 114246175
esophageal tumor9 / 17290520
gastrointestinal tumor13 / 119369108
germ cell tumor102 / 263845386
glioma23 / 106883215
head and neck tumor66 / 136302484
kidney tumor27 / 68959391
leukemia7 / 9584273
liver tumor17 / 96359176
lung tumor9 / 10312787
lymphoma5 / 7175569
non-neoplasia50 / 97250514
normal1380 / 3360307410
ovarian tumor7 / 7668291
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer11 / 102680107
retinoblastoma2 / 4635643
skin tumor25 / 124949200
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor18 / 90257199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland7 / 33197210
ascites3 / 4001574
bladder5 / 29757168
blood27 / 123478218
bone3 / 7165541
bone marrow10 / 48801204
brain1056 / 1100989959
cervix4 / 4817183
connective tissue46 / 149255308
ear4 / 16212246
embryonic tissue25 / 215722115
esophagus9 / 20209445
eye12 / 21105456
heart10 / 89626111
intestine30 / 234472127
kidney62 / 211777292
larynx6 / 24145248
liver33 / 207743158
lung53 / 336974157
lymph3 / 4427067
lymph node20 / 91610218
mammary gland31 / 153271202
mouth52 / 67052775
muscle10 / 10771592
nerve2 / 15768126
ovary13 / 102051127
pancreas44 / 214812204
parathyroid13 / 20539632
pharynx9 / 41328217
pituitary gland3 / 16585180
placenta65 / 280825231
prostate38 / 189345200
salivary gland0 / 201550 
skin49 / 210574232
spleen6 / 53952111
stomach11 / 96619113
testis121 / 330442366
thymus48 / 81131591
thyroid15 / 47473315
tonsil0 / 169990 
trachea58 / 524131106
umbilical cord0 / 136800 
uterus78 / 232878334
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203042_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.8
Adipocyte79.1
AdrenalCortex25.35
Adrenalgland80.45
Amygdala67.35
Appendix22.8
AtrioventricularNode18.5
BDCA4+_DentriticCells33.5
Bonemarrow35.15
BronchialEpithelialCells69.45
CD105+_Endothelial26.55
CD14+_Monocytes89.05
CD19+_BCells(neg._sel.)21.95
CD33+_Myeloid126.25
CD34+40.15
CD4+_Tcells16.95
CD56+_NKCells30.9
CD71+_EarlyErythroid20.6
CD8+_Tcells9.65
CardiacMyocytes35.7
Caudatenucleus53.8
Cerebellum18.7
CerebellumPeduncles22.2
CiliaryGanglion16.05
CingulateCortex28.75
Colorectaladenocarcinoma21.75
DorsalRootGanglion14.85
FetalThyroid24.9
Fetalbrain13.25
Fetalliver51.05
Fetallung48.7
GlobusPallidus17.95
Heart32.5
Hypothalamus108.75
Kidney129.95
Leukemia_chronicMyelogenousK-56226.8
Leukemia_promyelocytic-HL-6014.5
Leukemialymphoblastic(MOLT-4)8.95
Liver132.1
Lung63.65
Lymphnode30.95
Lymphoma_burkitts(Daudi)19.8
Lymphoma_burkitts(Raji)23
MedullaOblongata35
OccipitalLobe40.6
OlfactoryBulb50.8
Ovary14.8
Pancreas30.45
PancreaticIslet67.2
ParietalLobe42.3
Pituitary32.35
Placenta221
Pons19.95
PrefrontalCortex61.15
Prostate362.75
Salivarygland73.8
SkeletalMuscle27.45
Skin20.1
SmoothMuscle106.8
Spinalcord156.75
SubthalamicNucleus18.75
SuperiorCervicalGanglion32
TemporalLobe21.35
Testis22.4
TestisGermCell14.7
TestisIntersitial12.75
TestisLeydigCell16.25
TestisSeminiferousTubule16.6
Thalamus64.7
Thymus21.55
Thyroid104.25
Tongue22.5
Tonsil16.9
Trachea53.55
TrigeminalGanglion26.65
Uterus47.1
UterusCorpus22.4
WholeBlood488.4
Wholebrain108.45
colon78.65
pineal_day29.52
pineal_night26.7
retina71.5
small_intestine120.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P85495
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.94 ± 0.97
Basal Forebrain1.51 ± 0.18
Basal Part of Pons1.16 ± 0.33
Cerebellar Cortex1.3 ± 0.57
Cerebellar Nuclei1.77 ± 0.73
Claustrum2.37 ± 0.83
Epithalamus1.32 ± 0.72
Frontal Lobe1.36 ± 0.58
Globus Pallidus2.16 ± 0.55
Hypothalamus1.66 ± 0.71
Insula1.43 ± 0.51
Limbic Lobe1.53 ± 0.6
Mesencephalon1.65 ± 0.63
Myelencephalon1.55 ± 0.64
Occipital Lobe1.55 ± 0.58
Parietal Lobe1.51 ± 0.7
Pontine Tegmentum1.61 ± 0.7
Striatum1.76 ± 0.56
Subthalamus1.64 ± 0.57
Temporal Lobe1.41 ± 0.58
Thalamus1.49 ± 0.56
White Matter2.59 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lamp2CBCerebellum0
0
Lamp2CTXCerebral cortex0
0
Lamp2HIPHippocampal region0
0
Lamp2HPFHippocampal formation0
0
Lamp2HYHypothalamus0
0
Lamp2LSXLateral septal complex0
0
Lamp2MBMidbrain0
0
Lamp2MYMedulla0
0
Lamp2OLFOlfactory bulb0
0
Lamp2PPons0
0
Lamp2PALPallidum0
0
Lamp2RHPRetrohippocampal region0
0
Lamp2sAMYStriatum-like amygdalar nuclei0
0
Lamp2STRStriatum0
0
Lamp2STRdStriatum dorsal region0
0
Lamp2STRvStriatum ventral region0
0
Lamp2THThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LAMP2_HUMAN_132 12 132 143 GILTVDELLAIR PRIDE
LAMP2_HUMAN_144 8 144 151 IPLNDLFR PRIDE
LAMP2_HUMAN_145 8 145 152 IPLNDLFR PRIDE
LAMP2_HUMAN_280 9 280 288 YLDFVFAVK PRIDE
PAp00001240 9 153 161 CNSLSTLEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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