AutismKB 2.0

Annotation Detail for LASP1


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Basic Information Top
Gene Symbol:LASP1 ( Lasp-1,MLN50 )
Gene Full Name: LIM and SH3 protein 1
Band: 17q12
Quick LinksEntrez ID:3927; OMIM: 602920; Uniprot ID:LASP1_HUMAN; ENSEMBL ID: ENSG00000002834; HGNC ID: 6513
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200618_at
Cell line Expression level Expression bar
721_B_lymphoblasts1231.6
Adipocyte797
AdrenalCortex96.4
Adrenalgland261.05
Amygdala387.05
Appendix101.9
AtrioventricularNode79
BDCA4+_DentriticCells1500.6
Bonemarrow649.95
BronchialEpithelialCells781.4
CD105+_Endothelial593.45
CD14+_Monocytes1495.25
CD19+_BCells(neg._sel.)820.8
CD33+_Myeloid2168.35
CD34+1144.4
CD4+_Tcells1444.55
CD56+_NKCells2919.55
CD71+_EarlyErythroid147.05
CD8+_Tcells1232.1
CardiacMyocytes1087.8
Caudatenucleus131.75
Cerebellum268.4
CerebellumPeduncles114.9
CiliaryGanglion106.85
CingulateCortex252.3
Colorectaladenocarcinoma2369.2
DorsalRootGanglion90.15
FetalThyroid334.5
Fetalbrain813.55
Fetalliver451.55
Fetallung568.05
GlobusPallidus126.1
Heart187.1
Hypothalamus384.05
Kidney346.75
Leukemia_chronicMyelogenousK-562379
Leukemia_promyelocytic-HL-60203.95
Leukemialymphoblastic(MOLT-4)364.7
Liver482.25
Lung593.2
Lymphnode466.1
Lymphoma_burkitts(Daudi)372.55
Lymphoma_burkitts(Raji)349.9
MedullaOblongata167
OccipitalLobe234.35
OlfactoryBulb347.85
Ovary86
Pancreas430.4
PancreaticIslet372.95
ParietalLobe142
Pituitary206.1
Placenta775
Pons101.1
PrefrontalCortex618.2
Prostate238.7
Salivarygland225.65
SkeletalMuscle48.4
Skin115.3
SmoothMuscle1309.9
Spinalcord229.05
SubthalamicNucleus146.05
SuperiorCervicalGanglion172.2
TemporalLobe149.05
Testis130.45
TestisGermCell65.45
TestisIntersitial14.65
TestisLeydigCell26.75
TestisSeminiferousTubule36.55
Thalamus309.35
Thymus814.85
Thyroid381.95
Tongue74.65
Tonsil466.7
Trachea312.2
TrigeminalGanglion57.05
Uterus308.5
UterusCorpus101.5
WholeBlood2474.85
Wholebrain406.95
colon1279.95
pineal_day817.88
pineal_night911.24
retina749.35
small_intestine1618.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9541_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.32 ± 0.81
Basal Forebrain3.55 ± 0.38
Basal Part of Pons3.57 ± 0.6
Cerebellar Cortex3.33 ± 0.51
Cerebellar Nuclei3.34 ± 0.68
Claustrum4.67 ± 0.76
Epithalamus3.16 ± 0.71
Frontal Lobe3.61 ± 0.6
Globus Pallidus4.15 ± 0.55
Hypothalamus3.45 ± 0.52
Insula3.76 ± 0.53
Limbic Lobe4.03 ± 0.68
Mesencephalon3.8 ± 0.62
Myelencephalon3.8 ± 0.67
Occipital Lobe4.08 ± 0.66
Parietal Lobe3.93 ± 0.73
Pontine Tegmentum3.76 ± 0.69
Striatum3.86 ± 0.73
Subthalamus3.51 ± 0.41
Temporal Lobe3.68 ± 0.59
Thalamus3.85 ± 0.48
White Matter3.11 ± 1.02
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LASP1_HUMAN_0 0 0 0 EPAAPVSIQR PRIDE
LASP1_HUMAN_0 0 0 0 GFSVVADTPELQR PRIDE
LASP1_HUMAN_0 0 0 0 LKQQSELQSQVR PRIDE
LASP1_HUMAN_0 0 0 0 TGDTGMLPANYVEAI PRIDE
LASP1_HUMAN_0 0 0 0 TQDQISNIKYHEEFEK PRIDE
LASP1_HUMAN_1 7 1 7 MNPNCAR PRIDE
LASP1_HUMAN_100 10 100 109 VVADTPELQR PRIDE
LASP1_HUMAN_111 17 111 127 KTQDQISNIKYHEEFEK PRIDE
LASP1_HUMAN_112 16 112 127 TQDQISNIKYHEEFEK PRIDE
LASP1_HUMAN_112 18 112 129 TQDQISNIKYHEEFEKSR PRIDE
LASP1_HUMAN_130 14 130 143 MGPSGGEGMEPERR PRIDE
LASP1_HUMAN_131 13 131 143 MGPSGGEGMEPER PRIDE
LASP1_HUMAN_187 10 187 196 EPAAPVSIQR PRIDE
LASP1_HUMAN_246 15 246 260 TGDTGMLPANYVEAI PRIDE
LASP1_HUMAN_247 15 247 261 TGDTGMLPANYVEAI PRIDE
LASP1_HUMAN_59 14 59 72 QSFTMVADTPENLR PRIDE
LASP1_HUMAN_60 14 60 73 QSFTMVADTPENLR PRIDE
LASP1_HUMAN_73 12 73 84 LKQQSELQSQVR PRIDE
LASP1_HUMAN_76 10 76 85 QQSELQSQVR PRIDE
LASP1_HUMAN_96 13 96 108 GFSVVADTPELQR PRIDE
PAp00004538 10 50 59 KPYCNAHYPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018