AutismKB 2.0

Annotation Detail for ARHGAP4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARHGAP4 ( C1,KIAA0131,RGC1,RhoGAP4,SrGAP4,p115 )
Gene Full Name: Rho GTPase activating protein 4
Band: Xq28
Quick LinksEntrez ID:393; OMIM: 300023; Uniprot ID:RHG04_HUMAN; ENSEMBL ID: ENSG00000089820; HGNC ID: 674
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus11 / 56401219
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult110 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor10 / 26384537
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia57 / 95842594
liver tumor4 / 9635941
lung tumor11 / 103127106
lymphoma7 / 7175597
non-neoplasia0 / 972500 
normal96 / 336030728
ovarian tumor1 / 7668213
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood16 / 123478129
bone2 / 7165527
bone marrow50 / 488011024
brain17 / 110098915
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine8 / 23447234
kidney1 / 2117774
larynx0 / 241450 
liver6 / 20774328
lung14 / 33697441
lymph4 / 4427090
lymph node12 / 91610130
mammary gland5 / 15327132
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen11 / 53952203
stomach3 / 9661931
testis4 / 33044212
thymus22 / 81131271
thyroid0 / 474730 
tonsil3 / 16999176
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204425_at
Cell line Expression level Expression bar
721_B_lymphoblasts71.5
Adipocyte5.75
AdrenalCortex7.25
Adrenalgland5.4
Amygdala6.35
Appendix7.15
AtrioventricularNode5.05
BDCA4+_DentriticCells211.4
Bonemarrow10.45
BronchialEpithelialCells5.5
CD105+_Endothelial6.7
CD14+_Monocytes149.25
CD19+_BCells(neg._sel.)122.15
CD33+_Myeloid150.3
CD34+86.25
CD4+_Tcells311.95
CD56+_NKCells156.75
CD71+_EarlyErythroid6.55
CD8+_Tcells261.9
CardiacMyocytes8.8
Caudatenucleus5.8
Cerebellum5.35
CerebellumPeduncles7.85
CiliaryGanglion4.65
CingulateCortex6.2
Colorectaladenocarcinoma17.45
DorsalRootGanglion5.25
FetalThyroid7.3
Fetalbrain5.8
Fetalliver5.65
Fetallung5.5
GlobusPallidus4.7
Heart9.95
Hypothalamus6.55
Kidney5.35
Leukemia_chronicMyelogenousK-5625.9
Leukemia_promyelocytic-HL-606.85
Leukemialymphoblastic(MOLT-4)18.2
Liver10.05
Lung7.2
Lymphnode15.75
Lymphoma_burkitts(Daudi)10.55
Lymphoma_burkitts(Raji)66.8
MedullaOblongata6
OccipitalLobe5.35
OlfactoryBulb5.2
Ovary4.35
Pancreas5
PancreaticIslet6.95
ParietalLobe7.5
Pituitary8.45
Placenta8.15
Pons5.75
PrefrontalCortex7.25
Prostate7.6
Salivarygland8.45
SkeletalMuscle7.35
Skin4.8
SmoothMuscle6.4
Spinalcord7.65
SubthalamicNucleus6
SuperiorCervicalGanglion7.35
TemporalLobe6
Testis4.75
TestisGermCell5.2
TestisIntersitial5.5
TestisLeydigCell6.05
TestisSeminiferousTubule5.1
Thalamus6.65
Thymus18.35
Thyroid8
Tongue9.85
Tonsil15.05
Trachea5.25
TrigeminalGanglion6.25
Uterus4.4
UterusCorpus5.5
WholeBlood70.75
Wholebrain4.6
colon6.6
pineal_day11.66
pineal_night10.3
retina7.55
small_intestine7.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P159927
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.85 ± 0.45
Basal Forebrain7.6 ± 0.2
Basal Part of Pons8.35 ± 0.4
Cerebellar Cortex8.64 ± 0.44
Cerebellar Nuclei8.75 ± 0.27
Claustrum8.37 ± 0.61
Epithalamus9.66 ± 1.04
Frontal Lobe7.95 ± 0.64
Globus Pallidus8 ± 0.6
Hypothalamus7.91 ± 0.45
Insula8.3 ± 0.48
Limbic Lobe7.9 ± 0.76
Mesencephalon7.92 ± 0.49
Myelencephalon7.92 ± 0.7
Occipital Lobe7.08 ± 0.46
Parietal Lobe7.6 ± 0.47
Pontine Tegmentum7.85 ± 0.49
Striatum7.45 ± 0.57
Subthalamus8.32 ± 0.17
Temporal Lobe7.98 ± 0.6
Thalamus7.4 ± 0.36
White Matter8.28 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arhgap4CBCerebellum0.42
0.59
Arhgap4CTXCerebral cortex1.28
0.7
Arhgap4HIPHippocampal region0.87
0.58
Arhgap4HPFHippocampal formation0.82
0.51
Arhgap4HYHypothalamus1.02
0.77
Arhgap4LSXLateral septal complex0.15
0
Arhgap4MBMidbrain1.09
0.91
Arhgap4MYMedulla1.07
0.78
Arhgap4OLFOlfactory bulb1.56
0.88
Arhgap4PPons1.55
0.95
Arhgap4PALPallidum0.73
0.37
Arhgap4RHPRetrohippocampal region0.76
0.43
Arhgap4sAMYStriatum-like amygdalar nuclei1.68
1.58
Arhgap4STRStriatum0.81
0.66
Arhgap4STRdStriatum dorsal region0.88
0.8
Arhgap4STRvStriatum ventral region0.6
0.25
Arhgap4THThalamus0.48
0.41
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved