AutismKB 2.0

Annotation Detail for LBR


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Basic Information Top
Gene Symbol:LBR ( DHCR14B,FLJ43126,LMN2R,MGC9041,PHA )
Gene Full Name: lamin B receptor
Band: 1q42.12
Quick LinksEntrez ID:3930; OMIM: 600024; Uniprot ID:LBR_HUMAN; ENSEMBL ID: ENSG00000143815; HGNC ID: 6518
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst11 / 62319176
fetus54 / 56401295
neonate1 / 3109732
infant2 / 2362084
juvenile2 / 5555635
adult123 / 193912163
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor10 / 11936983
germ cell tumor45 / 263845170
glioma2 / 10688318
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia15 / 95842156
liver tumor5 / 9635951
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal234 / 336030769
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor7 / 12494956
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder3 / 29757100
blood37 / 123478299
bone1 / 7165513
bone marrow4 / 4880181
brain66 / 110098959
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus0 / 202090 
eye5 / 21105423
heart6 / 8962666
intestine15 / 23447263
kidney15 / 21177770
larynx0 / 241450 
liver13 / 20774362
lung18 / 33697453
lymph1 / 4427022
lymph node22 / 91610240
mammary gland2 / 15327113
mouth8 / 67052119
muscle4 / 10771537
nerve0 / 157680 
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta18 / 28082564
prostate5 / 18934526
salivary gland0 / 201550 
skin8 / 21057437
spleen3 / 5395255
stomach6 / 9661962
testis67 / 330442202
thymus32 / 81131394
thyroid0 / 474730 
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord0 / 136800 
uterus43 / 232878184
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201795_at
Cell line Expression level Expression bar
721_B_lymphoblasts976.15
Adipocyte38.2
AdrenalCortex10.4
Adrenalgland13.25
Amygdala19.45
Appendix31.55
AtrioventricularNode15.8
BDCA4+_DentriticCells434.25
Bonemarrow367.75
BronchialEpithelialCells43
CD105+_Endothelial939.95
CD14+_Monocytes429
CD19+_BCells(neg._sel.)414.35
CD33+_Myeloid597.75
CD34+521.35
CD4+_Tcells440.1
CD56+_NKCells585.55
CD71+_EarlyErythroid1444.85
CD8+_Tcells555.85
CardiacMyocytes75.7
Caudatenucleus9.3
Cerebellum4.2
CerebellumPeduncles11.8
CiliaryGanglion8
CingulateCortex11.6
Colorectaladenocarcinoma104.55
DorsalRootGanglion12.2
FetalThyroid26.75
Fetalbrain57
Fetalliver363.45
Fetallung89.4
GlobusPallidus4.45
Heart6.3
Hypothalamus40.25
Kidney16.7
Leukemia_chronicMyelogenousK-562205.5
Leukemia_promyelocytic-HL-60540.55
Leukemialymphoblastic(MOLT-4)648.55
Liver13.2
Lung15.5
Lymphnode149.5
Lymphoma_burkitts(Daudi)497.1
Lymphoma_burkitts(Raji)403.75
MedullaOblongata11.45
OccipitalLobe11.9
OlfactoryBulb23.5
Ovary36.6
Pancreas96.7
PancreaticIslet59.7
ParietalLobe7.35
Pituitary18.3
Placenta42.6
Pons12.95
PrefrontalCortex38.45
Prostate35.3
Salivarygland24.35
SkeletalMuscle12.55
Skin17.15
SmoothMuscle30.65
Spinalcord38.15
SubthalamicNucleus4.55
SuperiorCervicalGanglion18.65
TemporalLobe10.15
Testis22.45
TestisGermCell45.15
TestisIntersitial23.9
TestisLeydigCell26.2
TestisSeminiferousTubule21.8
Thalamus9.2
Thymus361
Thyroid30.25
Tongue21.9
Tonsil197.8
Trachea21.3
TrigeminalGanglion16.2
Uterus205.1
UterusCorpus17.6
WholeBlood1317
Wholebrain7.75
colon302.45
pineal_day24.22
pineal_night22.52
retina34.75
small_intestine391.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P200493
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.74 ± 0.32
Basal Forebrain8.06 ± 0.31
Basal Part of Pons8.11 ± 0.3
Cerebellar Cortex7.91 ± 0.15
Cerebellar Nuclei8.55 ± 0.23
Claustrum7.6 ± 0.39
Epithalamus8.44 ± 0.27
Frontal Lobe8.1 ± 0.36
Globus Pallidus8.89 ± 0.21
Hypothalamus8.29 ± 0.34
Insula7.98 ± 0.19
Limbic Lobe7.91 ± 0.35
Mesencephalon8.15 ± 0.38
Myelencephalon8.14 ± 0.35
Occipital Lobe8.17 ± 0.35
Parietal Lobe8.04 ± 0.32
Pontine Tegmentum8.18 ± 0.23
Striatum8.37 ± 0.28
Subthalamus8.36 ± 0.22
Temporal Lobe7.98 ± 0.28
Thalamus8.24 ± 0.25
White Matter9.67 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LbrCBCerebellum0.4
0.52
LbrCTXCerebral cortex0.42
0.77
LbrHIPHippocampal region0.1
0.16
LbrHPFHippocampal formation0.16
0.24
LbrHYHypothalamus0.09
0.09
LbrLSXLateral septal complex0.05
0
LbrMBMidbrain0.3
0.38
LbrMYMedulla0.52
0.63
LbrOLFOlfactory bulb0.46
1.11
LbrPPons0.16
0.27
LbrPALPallidum0.11
0.29
LbrRHPRetrohippocampal region0.28
0.35
LbrsAMYStriatum-like amygdalar nuclei0.13
0.56
LbrSTRStriatum0.26
0.38
LbrSTRdStriatum dorsal region0.36
0.48
LbrSTRvStriatum ventral region0.11
0.11
LbrTHThalamus0.47
0.58
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LBR_HUMAN_353 19 353 371 NDLSPASSGNAVYDFFIGR PRIDE
PAp00003090 27 14 40 GRWPGSSLYYEVEILSHDSTSQLYTVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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