AutismKB 2.0

Annotation Detail for LCAT


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Basic Information Top
Gene Symbol:LCAT ( - )
Gene Full Name: lecithin-cholesterol acyltransferase
Band: 16q22.1
Quick LinksEntrez ID:3931; OMIM: 606967; Uniprot ID:LCAT_HUMAN; ENSEMBL ID: ENSG00000213398; HGNC ID: 6522
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus22 / 56401239
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult59 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor1 / 2638453
glioma4 / 10688337
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal92 / 336030727
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder3 / 29757100
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain12 / 110098910
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye8 / 21105437
heart5 / 8962655
intestine4 / 23447217
kidney0 / 2117770 
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph0 / 442700 
lymph node2 / 9161021
mammary gland5 / 15327132
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta5 / 28082517
prostate16 / 18934584
salivary gland0 / 201550 
skin0 / 2105740 
spleen2 / 5395237
stomach5 / 9661951
testis2 / 3304426
thymus0 / 811310 
thyroid6 / 47473126
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209402_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.35
Adipocyte25.55
AdrenalCortex24.15
Adrenalgland24.9
Amygdala25
Appendix22.55
AtrioventricularNode21.85
BDCA4+_DentriticCells19.1
Bonemarrow27.3
BronchialEpithelialCells21.6
CD105+_Endothelial23.2
CD14+_Monocytes24.25
CD19+_BCells(neg._sel.)22.4
CD33+_Myeloid25.8
CD34+30.25
CD4+_Tcells23.35
CD56+_NKCells25.65
CD71+_EarlyErythroid21.3
CD8+_Tcells21.45
CardiacMyocytes28.25
Caudatenucleus20.35
Cerebellum21.75
CerebellumPeduncles29.05
CiliaryGanglion19.45
CingulateCortex22.7
Colorectaladenocarcinoma35.1
DorsalRootGanglion21.2
FetalThyroid22.35
Fetalbrain20.95
Fetalliver18.75
Fetallung18.5
GlobusPallidus16.4
Heart51.3
Hypothalamus22
Kidney18.1
Leukemia_chronicMyelogenousK-56223.3
Leukemia_promyelocytic-HL-6019.3
Leukemialymphoblastic(MOLT-4)20.95
Liver44.2
Lung82.3
Lymphnode22.2
Lymphoma_burkitts(Daudi)28.25
Lymphoma_burkitts(Raji)33.5
MedullaOblongata18.15
OccipitalLobe19.55
OlfactoryBulb18.05
Ovary20.8
Pancreas18
PancreaticIslet24.5
ParietalLobe23.35
Pituitary26.65
Placenta26.35
Pons21.5
PrefrontalCortex27.65
Prostate27
Salivarygland17.3
SkeletalMuscle23.3
Skin16.3
SmoothMuscle27.6
Spinalcord24.8
SubthalamicNucleus36.3
SuperiorCervicalGanglion25.1
TemporalLobe19.7
Testis22.95
TestisGermCell19.45
TestisIntersitial19.45
TestisLeydigCell22.5
TestisSeminiferousTubule28.95
Thalamus23.05
Thymus22.55
Thyroid51.25
Tongue26.5
Tonsil22.1
Trachea19.2
TrigeminalGanglion26.95
Uterus18.9
UterusCorpus19.95
WholeBlood28.75
Wholebrain20.7
colon20.95
pineal_day25.98
pineal_night23.46
retina25.575
small_intestine21.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15035_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.27 ± 0.48
Basal Forebrain6.2 ± 0.35
Basal Part of Pons6.21 ± 0.22
Cerebellar Cortex6.7 ± 0.3
Cerebellar Nuclei6.19 ± 0.33
Claustrum6.62 ± 0.45
Epithalamus6.63 ± 0.26
Frontal Lobe6.19 ± 0.43
Globus Pallidus6.43 ± 0.53
Hypothalamus6.27 ± 0.51
Insula6.11 ± 0.37
Limbic Lobe6.25 ± 0.5
Mesencephalon6.27 ± 0.37
Myelencephalon6.28 ± 0.42
Occipital Lobe6.37 ± 0.43
Parietal Lobe6.13 ± 0.41
Pontine Tegmentum6.13 ± 0.43
Striatum5.96 ± 0.36
Subthalamus6.05 ± 0.15
Temporal Lobe6.22 ± 0.42
Thalamus6.24 ± 0.32
White Matter6.26 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LcatCBCerebellum34.29
100
LcatCTXCerebral cortex14.43
9.58
LcatHIPHippocampal region22.28
19.37
LcatHPFHippocampal formation19.64
15.65
LcatHYHypothalamus4.29
3.71
LcatLSXLateral septal complex2.21
1.44
LcatMBMidbrain12.27
12.08
LcatMYMedulla19.86
18.12
LcatOLFOlfactory bulb23.47
21.1
LcatPPons14.74
13.54
LcatPALPallidum9.41
6.88
LcatRHPRetrohippocampal region16.38
11.46
LcatsAMYStriatum-like amygdalar nuclei6.2
4.99
LcatSTRStriatum6.25
4.37
LcatSTRdStriatum dorsal region6.57
4.76
LcatSTRvStriatum ventral region7.06
4.15
LcatTHThalamus11.12
8.6
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00026821 20 281 300 MAWPEDHVFISTPSFNYTGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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