Annotation Detail for LCK
Basic Information Top
| Gene Symbol: | LCK ( LSK,YT16,p56lck,pp58lck ) |
|---|---|
| Gene Full Name: | lymphocyte-specific protein tyrosine kinase |
| Band: | 1p35.2 |
| Quick Links | Entrez ID:3932; OMIM: 153390; Uniprot ID:LCK_HUMAN; ENSEMBL ID: ENSG00000182866; HGNC ID: 6524 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.470627
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 1 / 62319 | 16 |  |
| fetus | 7 / 564012 | 12 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 11 / 55556 | 197 |  |
| adult | 75 / 1939121 | 38 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 1 / 94178 | 10 |  |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 1 / 114246 | 8 | |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 3 / 119369 | 25 | |
| germ cell tumor | 3 / 263845 | 11 | |
| glioma | 2 / 106883 | 18 | |
| head and neck tumor | 5 / 136302 | 36 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 21 / 95842 | 219 |  |
| liver tumor | 1 / 96359 | 10 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 13 / 71755 | 181 | |
| non-neoplasia | 8 / 97250 | 82 | |
| normal | 138 / 3360307 | 41 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 11 / 90257 | 121 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 1 / 33197 | 30 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 46 / 123478 | 372 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 8 / 1100989 | 7 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 8 / 149255 | 53 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 5 / 215722 | 23 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 0 / 211054 | 0 | |
| heart | 1 / 89626 | 11 | |
| intestine | 4 / 234472 | 17 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 7 / 24145 | 289 | |
| liver | 3 / 207743 | 14 | |
| lung | 4 / 336974 | 11 | |
| lymph | 10 / 44270 | 225 | |
| lymph node | 11 / 91610 | 120 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 3 / 67052 | 44 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 2 / 214812 | 9 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 2 / 189345 | 10 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 28 / 53952 | 518 | |
| stomach | 3 / 96619 | 31 | |
| testis | 5 / 330442 | 15 | |
| thymus | 222 / 81131 | 2736 |  |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 12 / 16999 | 705 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 13 / 232878 | 55 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204890_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 352.55 | |
| Adipocyte | 4 | |
| AdrenalCortex | 4.5 | |
| Adrenalgland | 3.45 | |
| Amygdala | 4.2 | |
| Appendix | 4.15 | |
| AtrioventricularNode | 3.15 | |
| BDCA4+_DentriticCells | 31.2 | |
| Bonemarrow | 4.5 | |
| BronchialEpithelialCells | 4 | |
| CD105+_Endothelial | 4.05 | |
| CD14+_Monocytes | 4.3 | |
| CD19+_BCells(neg._sel.) | 19.45 | |
| CD33+_Myeloid | 5.15 | |
| CD34+ | 5.1 | |
| CD4+_Tcells | 1496.15 | |
| CD56+_NKCells | 387.7 | |
| CD71+_EarlyErythroid | 3.8 | |
| CD8+_Tcells | 1532.6 | |
| CardiacMyocytes | 5.95 | |
| Caudatenucleus | 3.6 | |
| Cerebellum | 3.3 | |
| CerebellumPeduncles | 4.7 | |
| CiliaryGanglion | 2.95 | |
| CingulateCortex | 4.2 | |
| Colorectaladenocarcinoma | 4.9 | |
| DorsalRootGanglion | 3.15 | |
| FetalThyroid | 3.9 | |
| Fetalbrain | 4 | |
| Fetalliver | 3.55 | |
| Fetallung | 3.3 | |
| GlobusPallidus | 3 | |
| Heart | 12.4 | |
| Hypothalamus | 4.4 | |
| Kidney | 3.35 | |
| Leukemia_chronicMyelogenousK-562 | 3.65 | |
| Leukemia_promyelocytic-HL-60 | 7.85 | |
| Leukemialymphoblastic(MOLT-4) | 535.85 | |
| Liver | 5.45 | |
| Lung | 8.5 | |
| Lymphnode | 77.05 | |
| Lymphoma_burkitts(Daudi) | 45.65 | |
| Lymphoma_burkitts(Raji) | 6.5 | |
| MedullaOblongata | 3.7 | |
| OccipitalLobe | 3.6 | |
| OlfactoryBulb | 3.15 | |
| Ovary | 2.7 | |
| Pancreas | 3.3 | |
| PancreaticIslet | 4.35 | |
| ParietalLobe | 4.3 | |
| Pituitary | 4.75 | |
| Placenta | 4.15 | |
| Pons | 3.8 | |
| PrefrontalCortex | 4.9 | |
| Prostate | 7.15 | |
| Salivarygland | 3.35 | |
| SkeletalMuscle | 4.85 | |
| Skin | 3.15 | |
| SmoothMuscle | 4.55 | |
| Spinalcord | 4.25 | |
| SubthalamicNucleus | 3.7 | |
| SuperiorCervicalGanglion | 4.6 | |
| TemporalLobe | 3.65 | |
| Testis | 3.5 | |
| TestisGermCell | 4.1 | |
| TestisIntersitial | 3.4 | |
| TestisLeydigCell | 4 | |
| TestisSeminiferousTubule | 3.45 | |
| Thalamus | 4.1 | |
| Thymus | 927.1 | |
| Thyroid | 5 | |
| Tongue | 4.05 | |
| Tonsil | 45.55 | |
| Trachea | 4.2 | |
| TrigeminalGanglion | 4.15 | |
| Uterus | 3.3 | |
| UterusCorpus | 6.05 | |
| WholeBlood | 127.9 | |
| Wholebrain | 3.4 | |
| colon | 4.05 | |
| pineal_day | 4.98 | |
| pineal_night | 4.88 | |
| retina | 4.9 | |
| small_intestine | 4.65 | |
- Probe name: CUST_12241_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.14 ± 0.93 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 1.63 ± 0.17 | |
| Basal Part of Pons | 1.3 ± 0.41 | |
| Cerebellar Cortex | 1.47 ± 0.73 | |
| Cerebellar Nuclei | 1.95 ± 0.73 | |
| Claustrum | 2.36 ± 0.72 | |
| Epithalamus | 1.3 ± 0.71 | |
| Frontal Lobe | 1.48 ± 0.55 | |
| Globus Pallidus | 2.17 ± 0.32 | |
| Hypothalamus | 1.69 ± 0.61 | |
| Insula | 1.84 ± 1.27 | |
| Limbic Lobe | 1.65 ± 0.68 | |
| Mesencephalon | 1.8 ± 0.67 | |
| Myelencephalon | 1.71 ± 0.68 | |
| Occipital Lobe | 1.69 ± 0.66 | |
| Parietal Lobe | 1.63 ± 0.64 | |
| Pontine Tegmentum | 1.63 ± 0.65 | |
| Striatum | 1.83 ± 0.46 | |
| Subthalamus | 1.8 ± 0.63 | |
| Temporal Lobe | 1.53 ± 0.65 | |
| Thalamus | 1.59 ± 0.59 | |
| White Matter | 2.12 ± 0.27 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Lck | CB | Cerebellum | 1.15 | |
| 1.69 | | |||
| Lck | CTX | Cerebral cortex | 1.73 | |
| 1.82 | | |||
| Lck | HIP | Hippocampal region | 3.5 | |
| 4.56 | | |||
| Lck | HPF | Hippocampal formation | 3.68 | |
| 3.97 | | |||
| Lck | HY | Hypothalamus | 0.75 | |
| 0.96 | | |||
| Lck | LSX | Lateral septal complex | 0.05 | |
| 0 | | |||
| Lck | MB | Midbrain | 0.76 | |
| 1.21 | | |||
| Lck | MY | Medulla | 5.49 | |
| 6.93 | | |||
| Lck | OLF | Olfactory bulb | 6.27 | |
| 4.78 | | |||
| Lck | P | Pons | 4.02 | |
| 6.34 | | |||
| Lck | PAL | Pallidum | 1.59 | |
| 1.18 | | |||
| Lck | RHP | Retrohippocampal region | 3.77 | |
| 2.97 | | |||
| Lck | sAMY | Striatum-like amygdalar nuclei | 3.22 | |
| 2.3 | | |||
| Lck | STR | Striatum | 1.93 | |
| 1.53 | | |||
| Lck | STRd | Striatum dorsal region | 0.67 | |
| 0.47 | | |||
| Lck | STRv | Striatum ventral region | 5.96 | |
| 4.58 | | |||
| Lck | TH | Thalamus | 0.71 | |
| 0.58 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| LCK_HUMAN_139 | 15 | 139 | 153 | QLLAPGNTHGSFLIR | PRIDE |
| LCK_HUMAN_168 | 11 | 168 | 178 | DFDQNQGEVVK | PRIDE |
| LCK_HUMAN_387 | 10 | 387 | 396 | LIEDNEYTAR | PRIDE |
| PAp00000174 | 13 | 367 | 379 | AANILVSDTLSCK | Peptide Atlas |