AutismKB 2.0

Annotation Detail for LCP1


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Basic Information Top
Gene Symbol:LCP1 ( CP64,DKFZp781A23186,FLJ25423,FLJ26114,FLJ39956,L-PLASTIN,LC64P,LPL,PLS2 )
Gene Full Name: lymphocyte cytosolic protein 1 (L-plastin)
Band: 13q14.13
Quick LinksEntrez ID:3936; OMIM: 153430; Uniprot ID:PLSL_HUMAN; ENSEMBL ID: ENSG00000136167; HGNC ID: 6528
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus21 / 56401237
neonate5 / 31097160
infant0 / 236200 
juvenile21 / 55556377
adult149 / 193912176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma14 / 82823169
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor3 / 11936925
germ cell tumor75 / 263845284
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia65 / 95842678
liver tumor4 / 9635941
lung tumor5 / 10312748
lymphoma89 / 717551240
non-neoplasia37 / 97250380
normal424 / 3360307126
ovarian tumor1 / 7668213
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood112 / 123478907
bone6 / 7165583
bone marrow23 / 48801471
brain36 / 110098932
cervix0 / 481710 
connective tissue42 / 149255281
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye2 / 2110549
heart7 / 8962678
intestine13 / 23447255
kidney3 / 21177714
larynx2 / 2414582
liver7 / 20774333
lung18 / 33697453
lymph76 / 442701716
lymph node109 / 916101189
mammary gland5 / 15327132
mouth2 / 6705229
muscle5 / 10771546
nerve1 / 1576863
ovary1 / 1020519
pancreas16 / 21481274
parathyroid0 / 205390 
pharynx19 / 41328459
pituitary gland0 / 165850 
placenta60 / 280825213
prostate15 / 18934579
salivary gland0 / 201550 
skin4 / 21057418
spleen33 / 53952611
stomach5 / 9661951
testis49 / 330442148
thymus186 / 811312292
thyroid2 / 4747342
tonsil25 / 169991470
trachea30 / 52413572
umbilical cord0 / 136800 
uterus14 / 23287860
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208885_at
Cell line Expression level Expression bar
721_B_lymphoblasts928.95
Adipocyte4.9
AdrenalCortex5.3
Adrenalgland4.4
Amygdala5.6
Appendix5.2
AtrioventricularNode3.9
BDCA4+_DentriticCells152.55
Bonemarrow55.3
BronchialEpithelialCells5
CD105+_Endothelial7.55
CD14+_Monocytes139.6
CD19+_BCells(neg._sel.)69.3
CD33+_Myeloid214.2
CD34+72.75
CD4+_Tcells109.25
CD56+_NKCells211.45
CD71+_EarlyErythroid4.9
CD8+_Tcells105.65
CardiacMyocytes5.9
Caudatenucleus4.7
Cerebellum4.3
CerebellumPeduncles5.65
CiliaryGanglion3.6
CingulateCortex5.35
Colorectaladenocarcinoma4.75
DorsalRootGanglion3.95
FetalThyroid4.85
Fetalbrain4.75
Fetalliver4.65
Fetallung5.45
GlobusPallidus3.8
Heart6.6
Hypothalamus5.8
Kidney4.25
Leukemia_chronicMyelogenousK-56215.65
Leukemia_promyelocytic-HL-6064.2
Leukemialymphoblastic(MOLT-4)74.55
Liver7.75
Lung6.1
Lymphnode35.7
Lymphoma_burkitts(Daudi)85.85
Lymphoma_burkitts(Raji)37.85
MedullaOblongata4.9
OccipitalLobe4.75
OlfactoryBulb4.2
Ovary3.45
Pancreas4.2
PancreaticIslet5.65
ParietalLobe5.5
Pituitary6.2
Placenta13.35
Pons5
PrefrontalCortex6.7
Prostate8.75
Salivarygland9.05
SkeletalMuscle7
Skin3.95
SmoothMuscle4.95
Spinalcord5.7
SubthalamicNucleus4.8
SuperiorCervicalGanglion9.8
TemporalLobe4.8
Testis4.65
TestisGermCell4.5
TestisIntersitial4.6
TestisLeydigCell11.6
TestisSeminiferousTubule5.55
Thalamus5.35
Thymus41.45
Thyroid6.05
Tongue5.1
Tonsil57
Trachea4.65
TrigeminalGanglion5.1
Uterus4.1
UterusCorpus4.65
WholeBlood1737.5
Wholebrain4.2
colon5.3
pineal_day5.72
pineal_night5.2
retina6.45
small_intestine5.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P181443
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.16 ± 1.18
Basal Forebrain1.95 ± 0.53
Basal Part of Pons1.38 ± 0.85
Cerebellar Cortex1.92 ± 0.93
Cerebellar Nuclei2.13 ± 0.73
Claustrum2.79 ± 1
Epithalamus1.46 ± 0.74
Frontal Lobe1.74 ± 0.83
Globus Pallidus2.79 ± 0.76
Hypothalamus2.15 ± 1.33
Insula1.93 ± 0.6
Limbic Lobe1.79 ± 0.76
Mesencephalon2 ± 0.75
Myelencephalon1.79 ± 0.8
Occipital Lobe1.92 ± 0.81
Parietal Lobe1.68 ± 0.94
Pontine Tegmentum2.15 ± 0.97
Striatum1.92 ± 0.79
Subthalamus2.37 ± 0.47
Temporal Lobe1.78 ± 0.81
Thalamus1.8 ± 0.77
White Matter3.88 ± 0.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lcp1CBCerebellum47.62
74.12
Lcp1CTXCerebral cortex61.85
44.55
Lcp1HIPHippocampal region45.25
56.81
Lcp1HPFHippocampal formation59.78
63.87
Lcp1HYHypothalamus41.04
31.94
Lcp1LSXLateral septal complex29.8
20.67
Lcp1MBMidbrain25.33
22.7
Lcp1MYMedulla47.47
56.4
Lcp1OLFOlfactory bulb70.54
62.49
Lcp1PPons38.24
42.43
Lcp1PALPallidum44.36
37.14
Lcp1RHPRetrohippocampal region87.38
76.14
Lcp1sAMYStriatum-like amygdalar nuclei59.57
40.72
Lcp1STRStriatum45.75
32.89
Lcp1STRdStriatum dorsal region44.32
31.33
Lcp1STRvStriatum ventral region55.26
41.71
Lcp1THThalamus47.79
37.3
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000135 10 40 49 AACLPLPGYR Peptide Atlas
PLSL_HUMAN_0 0 0 0 AYYHLLEQVAPK PRIDE
PLSL_HUMAN_0 0 0 0 EGKPYLVLGLLWQVIK PRIDE
PLSL_HUMAN_0 0 0 0 FSLVGIGGQDLNEGNR PRIDE
PLSL_HUMAN_0 0 0 0 ISFDEFIK PRIDE
PLSL_HUMAN_0 0 0 0 ISTSLPVLDLIDAIQPGSINYDLLK PRIDE
PLSL_HUMAN_0 0 0 0 KLENCNYAVELGK PRIDE
PLSL_HUMAN_0 0 0 0 LNLAFIANLFNR PRIDE
PLSL_HUMAN_0 0 0 0 LSPEELLLR PRIDE
PLSL_HUMAN_0 0 0 0 NEALIALLR PRIDE
PLSL_HUMAN_0 0 0 0 RYTLNILEEIGGGQK PRIDE
PLSL_HUMAN_0 0 0 0 VDTDGNGYISFNELNDLFK PRIDE
PLSL_HUMAN_0 0 0 0 VNDDIIVNWVNETLR PRIDE
PLSL_HUMAN_0 0 0 0 VNHLYSDLSDALVIFQLYEK PRIDE
PLSL_HUMAN_0 0 0 0 VYALPEDLVEVNPK PRIDE
PLSL_HUMAN_0 0 0 0 YTLNILEEIGGGQK PRIDE
PLSL_HUMAN_123 9 123 131 YAFVNWINK PRIDE
PLSL_HUMAN_141 24 141 164 HVIPMNPNTNDLFNAVGDGIVLCK PRIDE
PLSL_HUMAN_15 24 15 38 EAFAKVDTDGNGYISFNELNDLFK PRIDE
PLSL_HUMAN_165 13 165 177 MINLSVPDTIDER PRIDE
PLSL_HUMAN_183 34 183 216 KLTPFTIQENLNLALNSASAIGCHVVNIGAEDLK PRIDE
PLSL_HUMAN_184 33 184 216 LTPFTIQENLNLALNSASAIGCHVVNIGAEDLK PRIDE
PLSL_HUMAN_20 19 20 38 VDTDGNGYISFNELNDLFK PRIDE
PLSL_HUMAN_217 16 217 232 EGKPYLVLGLLWQVIK PRIDE
PLSL_HUMAN_233 11 233 243 IGLFADIELSR PRIDE
PLSL_HUMAN_244 28 244 271 NEALIALLREGESLEDLMKLSPEELLLR PRIDE
PLSL_HUMAN_244 9 244 252 NEALIALLR PRIDE
PLSL_HUMAN_245 9 245 253 NEALIALLR PRIDE
PLSL_HUMAN_253 10 253 262 EGESLEDLMK PRIDE
PLSL_HUMAN_253 19 253 271 EGESLEDLMKLSPEELLLR PRIDE
PLSL_HUMAN_255 18 255 272 GESLEDLMKLSPEELLLR PRIDE
PLSL_HUMAN_263 9 263 271 LSPEELLLR PRIDE
PLSL_HUMAN_272 13 272 284 WANYHLENAGCNK PRIDE
PLSL_HUMAN_285 12 285 296 IGNFSTDIKDSK PRIDE
PLSL_HUMAN_285 9 285 293 IGNFSTDIK PRIDE
PLSL_HUMAN_297 12 297 308 AYYHLLEQVAPK PRIDE
PLSL_HUMAN_297 29 297 325 AYYHLLEQVAPKGDEEGVPAVVIDMSGLR PRIDE
PLSL_HUMAN_297 31 297 327 AYYHLLEQVAPKGDEEGVPAVVIDMSGLREK PRIDE
PLSL_HUMAN_3 12 3 14 GSVSDEEMMELR PRIDE
PLSL_HUMAN_309 17 309 325 GDEEGVPAVVIDMSGLR PRIDE
PLSL_HUMAN_310 17 310 326 GDEEGVPAVVIDMSGLR PRIDE
PLSL_HUMAN_326 17 326 342 EKDDIQRAECMLQQAER PRIDE
PLSL_HUMAN_327 7 327 333 EKDDIQR PRIDE
PLSL_HUMAN_333 10 333 342 AECMLQQAER PRIDE
PLSL_HUMAN_334 10 334 343 AECMLQQAER PRIDE
PLSL_HUMAN_347 10 347 356 QFVTATDVVR PRIDE
PLSL_HUMAN_348 10 348 357 QFVTATDVVR PRIDE
PLSL_HUMAN_357 16 357 372 GNPKLNLAFIANLFNR PRIDE
PLSL_HUMAN_361 12 361 372 LNLAFIANLFNR PRIDE
PLSL_HUMAN_361 34 361 394 LNLAFIANLFNRYPALHKPENQDIDWGALEGETR PRIDE
PLSL_HUMAN_373 22 373 394 YPALHKPENQDIDWGALEGETR PRIDE
PLSL_HUMAN_373 25 373 397 YPALHKPENQDIDWGALEGETREER PRIDE
PLSL_HUMAN_374 22 374 395 YPALHKPENQDIDWGALEGETR PRIDE
PLSL_HUMAN_39 10 39 48 AACLPLPGYR PRIDE
PLSL_HUMAN_398 14 398 411 TFRNWMNSLGVNPR PRIDE
PLSL_HUMAN_4 12 4 15 GSVSDEEMMELR PRIDE
PLSL_HUMAN_401 11 401 411 NWMNSLGVNPR PRIDE
PLSL_HUMAN_402 11 402 412 NWMNSLGVNPR PRIDE
PLSL_HUMAN_412 20 412 431 VNHLYSDLSDALVIFQLYEK PRIDE
PLSL_HUMAN_412 29 412 440 VNHLYSDLSDALVIFQLYEKIKVPVDWNR PRIDE
PLSL_HUMAN_432 9 432 440 IKVPVDWNR PRIDE
PLSL_HUMAN_455 13 455 467 KLENCNYAVELGK PRIDE
PLSL_HUMAN_455 17 455 471 KLENCNYAVELGKNQAK PRIDE
PLSL_HUMAN_456 12 456 467 LENCNYAVELGK PRIDE
PLSL_HUMAN_456 16 456 471 LENCNYAVELGKNQAK PRIDE
PLSL_HUMAN_472 16 472 487 FSLVGIGGQDLNEGNR PRIDE
PLSL_HUMAN_474 15 474 488 SLVGIGGQDLNEGNR PRIDE
PLSL_HUMAN_488 12 488 499 TLTLALIWQLMR PRIDE
PLSL_HUMAN_488 13 488 500 TLTLALIWQLMRR PRIDE
PLSL_HUMAN_49 19 49 67 VREITENLMATGDLDQDGR PRIDE
PLSL_HUMAN_500 15 500 514 RYTLNILEEIGGGQK PRIDE
PLSL_HUMAN_501 14 501 514 YTLNILEEIGGGQK PRIDE
PLSL_HUMAN_51 17 51 67 EITENLMATGDLDQDGR PRIDE
PLSL_HUMAN_515 15 515 529 VNDDIIVNWVNETLR PRIDE
PLSL_HUMAN_52 17 52 68 EITENLMATGDLDQDGR PRIDE
PLSL_HUMAN_545 25 545 569 ISTSLPVLDLIDAIQPGSINYDLLK PRIDE
PLSL_HUMAN_570 14 570 583 TENLNDDEKLNNAK PRIDE
PLSL_HUMAN_570 21 570 590 TENLNDDEKLNNAKYAISMAR PRIDE
PLSL_HUMAN_571 14 571 584 TENLNDDEKLNNAK PRIDE
PLSL_HUMAN_584 7 584 590 YAISMAR PRIDE
PLSL_HUMAN_596 14 596 609 VYALPEDLVEVNPK PRIDE
PLSL_HUMAN_610 12 610 621 MVMTVFACLMGK PRIDE
PLSL_HUMAN_68 8 68 75 ISFDEFIK PRIDE
PLSL_HUMAN_77 12 77 88 IFHGLKSTDVAK PRIDE
PLSL_HUMAN_97 26 97 122 EGICAIGGTSEQSSVGTQHSYSEEEK PRIDE
PLSL_HUMAN_97 35 97 131 EGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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