AutismKB 2.0

Annotation Detail for LCP2


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Basic Information Top
Gene Symbol:LCP2 ( SLP-76,SLP76 )
Gene Full Name: lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Band: 5q35.1
Quick LinksEntrez ID:3937; OMIM: 601603; Uniprot ID:LCP2_HUMAN; ENSEMBL ID: ENSG00000043462; HGNC ID: 6529
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus9 / 56401215
neonate3 / 3109796
infant0 / 236200 
juvenile1 / 5555617
adult65 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia12 / 95842125
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia8 / 9725082
normal111 / 336030733
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood38 / 123478307
bone3 / 7165541
bone marrow3 / 4880161
brain15 / 110098913
cervix0 / 481710 
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine4 / 23447217
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth1 / 6705214
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta10 / 28082535
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen6 / 53952111
stomach2 / 9661920
testis3 / 3304429
thymus23 / 81131283
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205269_at
Cell line Expression level Expression bar
721_B_lymphoblasts27.3
Adipocyte8.05
AdrenalCortex15.9
Adrenalgland12.3
Amygdala8.75
Appendix20.85
AtrioventricularNode19.1
BDCA4+_DentriticCells129.7
Bonemarrow75.9
BronchialEpithelialCells8.5
CD105+_Endothelial19.5
CD14+_Monocytes331.05
CD19+_BCells(neg._sel.)11.05
CD33+_Myeloid462.75
CD34+185.85
CD4+_Tcells596.2
CD56+_NKCells726.05
CD71+_EarlyErythroid9.35
CD8+_Tcells705.15
CardiacMyocytes25.65
Caudatenucleus8
Cerebellum7.55
CerebellumPeduncles13.95
CiliaryGanglion20.55
CingulateCortex11.1
Colorectaladenocarcinoma7.85
DorsalRootGanglion14.5
FetalThyroid11.55
Fetalbrain7.6
Fetalliver10.75
Fetallung7.3
GlobusPallidus11
Heart24.2
Hypothalamus9
Kidney10.6
Leukemia_chronicMyelogenousK-56219.4
Leukemia_promyelocytic-HL-608.05
Leukemialymphoblastic(MOLT-4)17.6
Liver19.85
Lung81
Lymphnode66.45
Lymphoma_burkitts(Daudi)13.15
Lymphoma_burkitts(Raji)15.65
MedullaOblongata8.95
OccipitalLobe8.95
OlfactoryBulb11.55
Ovary9.85
Pancreas8.4
PancreaticIslet11.75
ParietalLobe13.4
Pituitary11.95
Placenta16.15
Pons10.4
PrefrontalCortex14.25
Prostate10.6
Salivarygland9.75
SkeletalMuscle22.35
Skin15.7
SmoothMuscle10.45
Spinalcord10.2
SubthalamicNucleus10.2
SuperiorCervicalGanglion29
TemporalLobe10.25
Testis7.9
TestisGermCell6.6
TestisIntersitial10.3
TestisLeydigCell11.4
TestisSeminiferousTubule8.35
Thalamus10.45
Thymus207.35
Thyroid12.45
Tongue16.65
Tonsil40.95
Trachea7.65
TrigeminalGanglion24.15
Uterus7.35
UterusCorpus11
WholeBlood582.5
Wholebrain6.8
colon14.7
pineal_day10.28
pineal_night10.66
retina12.2
small_intestine40.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6063_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.8 ± 0.88
Basal Forebrain3.75 ± 0.7
Basal Part of Pons4.01 ± 0.64
Cerebellar Cortex2.99 ± 0.39
Cerebellar Nuclei4.12 ± 0.63
Claustrum4.39 ± 0.67
Epithalamus4.09 ± 0.56
Frontal Lobe4.27 ± 0.66
Globus Pallidus4.48 ± 0.63
Hypothalamus3.78 ± 0.58
Insula3.57 ± 0.51
Limbic Lobe3.32 ± 0.61
Mesencephalon3.77 ± 0.74
Myelencephalon3.73 ± 0.71
Occipital Lobe3.1 ± 0.83
Parietal Lobe3.96 ± 0.45
Pontine Tegmentum3.75 ± 0.72
Striatum3.39 ± 0.9
Subthalamus4.21 ± 1.24
Temporal Lobe3.41 ± 0.6
Thalamus3.69 ± 0.71
White Matter3.96 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lcp2CBCerebellum1.47
2.35
Lcp2CTXCerebral cortex0.28
0.37
Lcp2HIPHippocampal region0.3
1
Lcp2HPFHippocampal formation0.33
0.79
Lcp2HYHypothalamus0.12
0.16
Lcp2LSXLateral septal complex0.56
0.5
Lcp2MBMidbrain0.37
0.87
Lcp2MYMedulla1.07
1.35
Lcp2OLFOlfactory bulb0.54
1.43
Lcp2PPons0.2
0.29
Lcp2PALPallidum0.02
0.19
Lcp2RHPRetrohippocampal region0.34
0.4
Lcp2sAMYStriatum-like amygdalar nuclei0.14
0.21
Lcp2STRStriatum0.18
0.21
Lcp2STRdStriatum dorsal region0.16
0.22
Lcp2STRvStriatum ventral region0.1
0.11
Lcp2THThalamus0.42
0.6
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LCP2_HUMAN_0 0 0 0 KYHIDGARFLNLTENDIQK PRIDE
LCP2_HUMAN_204 17 204 220 NHSPLPPPQTNHEEPSR PRIDE
LCP2_HUMAN_281 22 281 302 IQKPPLPPTTERHERSSPLPGK PRIDE
LCP2_HUMAN_37 19 37 55 KYHIDGARFLNLTENDIQK PRIDE
LCP2_HUMAN_478 12 478 489 ESQVYLLGTGLR PRIDE
LCP2_HUMAN_490 16 490 505 GKEDFLSVSDIIDYFR PRIDE
LCP2_HUMAN_490 17 490 506 GKEDFLSVSDIIDYFRK PRIDE
PAp00077298 16 10 25 SEVLGWDPDSLADYFK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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