AutismKB 2.0

Annotation Detail for ARHGAP5


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Basic Information Top
Gene Symbol:ARHGAP5 ( GFI2,RhoGAP5,p190-B,p190BRhoGAP )
Gene Full Name: Rho GTPase activating protein 5
Band: 14q12
Quick LinksEntrez ID:394; OMIM: 602680; Uniprot ID:RHG05_HUMAN; ENSEMBL ID: ENSG00000100852; HGNC ID: 675
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus38 / 56401267
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult146 / 193912175
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor7 / 9417874
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor11 / 11424696
esophageal tumor2 / 17290115
gastrointestinal tumor15 / 119369125
germ cell tumor11 / 26384541
glioma4 / 10688337
head and neck tumor15 / 136302110
kidney tumor3 / 6895943
leukemia2 / 9584220
liver tumor7 / 9635972
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia9 / 9725092
normal208 / 336030761
ovarian tumor2 / 7668226
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma3 / 4635664
skin tumor4 / 12494932
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites1 / 4001524
bladder6 / 29757201
blood1 / 1234788
bone1 / 7165513
bone marrow3 / 4880161
brain71 / 110098964
cervix3 / 4817162
connective tissue4 / 14925526
ear1 / 1621261
embryonic tissue15 / 21572269
esophagus2 / 2020998
eye11 / 21105452
heart3 / 8962633
intestine15 / 23447263
kidney15 / 21177770
larynx2 / 2414582
liver10 / 20774348
lung22 / 33697465
lymph0 / 442700 
lymph node0 / 916100 
mammary gland25 / 153271163
mouth6 / 6705289
muscle7 / 10771564
nerve1 / 1576863
ovary3 / 10205129
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta20 / 28082571
prostate11 / 18934558
salivary gland1 / 2015549
skin7 / 21057433
spleen1 / 5395218
stomach14 / 96619144
testis18 / 33044254
thymus2 / 8113124
thyroid8 / 47473168
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus14 / 23287860
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217936_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.7
Adipocyte9.25
AdrenalCortex11.9
Adrenalgland9.45
Amygdala75.05
Appendix16.5
AtrioventricularNode11.15
BDCA4+_DentriticCells9.95
Bonemarrow12.3
BronchialEpithelialCells9.7
CD105+_Endothelial9.25
CD14+_Monocytes10.35
CD19+_BCells(neg._sel.)11.6
CD33+_Myeloid10.4
CD34+12.05
CD4+_Tcells12
CD56+_NKCells9.95
CD71+_EarlyErythroid9.5
CD8+_Tcells9.15
CardiacMyocytes12.45
Caudatenucleus36.95
Cerebellum21.55
CerebellumPeduncles21.2
CiliaryGanglion9.6
CingulateCortex21.9
Colorectaladenocarcinoma10.4
DorsalRootGanglion12.2
FetalThyroid12.15
Fetalbrain50.15
Fetalliver17.4
Fetallung14.15
GlobusPallidus12.85
Heart17.25
Hypothalamus99.1
Kidney8.2
Leukemia_chronicMyelogenousK-5628.75
Leukemia_promyelocytic-HL-608.7
Leukemialymphoblastic(MOLT-4)11.8
Liver13.95
Lung8.9
Lymphnode7.5
Lymphoma_burkitts(Daudi)13.8
Lymphoma_burkitts(Raji)14.4
MedullaOblongata29.6
OccipitalLobe48.05
OlfactoryBulb14.05
Ovary8.6
Pancreas10.2
PancreaticIslet13.6
ParietalLobe14.75
Pituitary21.05
Placenta9.15
Pons16.75
PrefrontalCortex120.9
Prostate13.95
Salivarygland33.1
SkeletalMuscle17.65
Skin17.4
SmoothMuscle10.45
Spinalcord33.9
SubthalamicNucleus14.25
SuperiorCervicalGanglion19.3
TemporalLobe17.5
Testis8.1
TestisGermCell10.6
TestisIntersitial10.35
TestisLeydigCell11.55
TestisSeminiferousTubule8.55
Thalamus34.25
Thymus6.45
Thyroid39.15
Tongue10.6
Tonsil10.2
Trachea17.55
TrigeminalGanglion15.45
Uterus23.3
UterusCorpus11.25
WholeBlood10.75
Wholebrain29.15
colon25.45
pineal_day381.06
pineal_night320.4
retina40.65
small_intestine25.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3202_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.05 ± 0.22
Basal Forebrain10.09 ± 0.24
Basal Part of Pons9.57 ± 0.22
Cerebellar Cortex9.9 ± 0.16
Cerebellar Nuclei9.88 ± 0.21
Claustrum10.08 ± 0.19
Epithalamus10.37 ± 0.37
Frontal Lobe9.85 ± 0.28
Globus Pallidus10.73 ± 0.23
Hypothalamus9.71 ± 0.34
Insula9.88 ± 0.26
Limbic Lobe9.86 ± 0.34
Mesencephalon10.14 ± 0.29
Myelencephalon9.94 ± 0.32
Occipital Lobe10.08 ± 0.21
Parietal Lobe9.95 ± 0.28
Pontine Tegmentum9.97 ± 0.21
Striatum10.12 ± 0.3
Subthalamus10.16 ± 0.08
Temporal Lobe9.84 ± 0.28
Thalamus10.05 ± 0.27
White Matter10.58 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arhgap5CBCerebellum21.42
100
Arhgap5CTXCerebral cortex29.63
21.9
Arhgap5HIPHippocampal region36.06
26.68
Arhgap5HPFHippocampal formation32
23.04
Arhgap5HYHypothalamus13.98
9.99
Arhgap5LSXLateral septal complex38.36
24.44
Arhgap5MBMidbrain16.64
13.75
Arhgap5MYMedulla20.75
20.54
Arhgap5OLFOlfactory bulb33.47
24.52
Arhgap5PPons23.37
19.98
Arhgap5PALPallidum18.36
15.02
Arhgap5RHPRetrohippocampal region26.6
18.13
Arhgap5sAMYStriatum-like amygdalar nuclei11.12
7.59
Arhgap5STRStriatum16.97
11.55
Arhgap5STRdStriatum dorsal region15.26
10.94
Arhgap5STRvStriatum ventral region18.51
11.34
Arhgap5THThalamus19.41
16.51
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00043359 23 1010 1032 YRLDLEGNEYPIHSTPNCHDHER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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