Annotation Detail for LDLR
Basic Information Top
| Gene Symbol: | LDLR ( FH,FHC,LDLCQ2 ) |
|---|---|
| Gene Full Name: | low density lipoprotein receptor |
| Band: | 19p13.2 |
| Quick Links | Entrez ID:3949; OMIM: 606945; Uniprot ID:LDLR_HUMAN; ENSEMBL ID: ENSG00000130164; HGNC ID: 6547 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.728190
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 0 / 564012 | 0 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 0 / 1939121 | 0 | |
| embryoid body | 6 / 70761 | 84 |  |
| blastocyst | 4 / 62319 | 64 | |
| fetus | 39 / 564012 | 69 | |
| neonate | 16 / 31097 | 514 |  |
| infant | 1 / 23620 | 42 |  |
| juvenile | 6 / 55556 | 107 | |
| adult | 223 / 1939121 | 115 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 0 / 3360307 | 0 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 1 / 104616 | 9 |  |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 | |
| adrenal tumor | 2 / 12794 | 156 | |
| bladder carcinoma | 1 / 17475 | 57 | |
| breast (mammary gland) tumor | 24 / 94178 | 254 | |
| cervical tumor | 4 / 34366 | 116 | |
| chondrosarcoma | 6 / 82823 | 72 | |
| colorectal tumor | 26 / 114246 | 227 | |
| esophageal tumor | 5 / 17290 | 289 | |
| gastrointestinal tumor | 18 / 119369 | 150 | |
| germ cell tumor | 70 / 263845 | 265 | |
| glioma | 7 / 106883 | 65 | |
| head and neck tumor | 43 / 136302 | 315 | |
| kidney tumor | 6 / 68959 | 87 | |
| leukemia | 10 / 95842 | 104 | |
| liver tumor | 13 / 96359 | 134 | |
| lung tumor | 7 / 103127 | 67 | |
| lymphoma | 8 / 71755 | 111 | |
| non-neoplasia | 4 / 97250 | 41 | |
| normal | 358 / 3360307 | 106 | |
| ovarian tumor | 5 / 76682 | 65 | |
| pancreatic tumor | 36 / 104616 | 344 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 37 / 102680 | 360 | |
| retinoblastoma | 6 / 46356 | 129 | |
| skin tumor | 11 / 124949 | 88 | |
| soft tissue/muscle tissue tumor | 1 / 125191 | 7 | |
| uterine tumor | 2 / 90257 | 22 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 0 / 1100989 | 0 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 | |
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 14 / 33197 | 421 | |
| ascites | 10 / 40015 | 249 | |
| bladder | 2 / 29757 | 67 | |
| blood | 4 / 123478 | 32 | |
| bone | 5 / 71655 | 69 | |
| bone marrow | 8 / 48801 | 163 | |
| brain | 100 / 1100989 | 90 | |
| cervix | 5 / 48171 | 103 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 13 / 215722 | 60 | |
| esophagus | 5 / 20209 | 247 | |
| eye | 7 / 211054 | 33 | |
| heart | 3 / 89626 | 33 | |
| intestine | 42 / 234472 | 179 | |
| kidney | 23 / 211777 | 108 | |
| larynx | 3 / 24145 | 124 | |
| liver | 27 / 207743 | 129 | |
| lung | 115 / 336974 | 341 | |
| lymph | 8 / 44270 | 180 | |
| lymph node | 6 / 91610 | 65 | |
| mammary gland | 30 / 153271 | 195 | |
| mouth | 40 / 67052 | 596 | |
| muscle | 7 / 107715 | 64 | |
| nerve | 2 / 15768 | 126 | |
| ovary | 19 / 102051 | 186 | |
| pancreas | 45 / 214812 | 209 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 23 / 280825 | 81 | |
| prostate | 46 / 189345 | 242 | |
| salivary gland | 2 / 20155 | 99 | |
| skin | 22 / 210574 | 104 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 6 / 96619 | 62 | |
| testis | 59 / 330442 | 178 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 49 / 52413 | 934 | |
| umbilical cord | 14 / 13680 | 1023 |  |
| uterus | 26 / 232878 | 111 | |
| vascular | 3 / 51780 | 57 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 202068_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 91.2 | |
| Adipocyte | 178.7 | |
| AdrenalCortex | 1319.45 | |
| Adrenalgland | 880.35 | |
| Amygdala | 8.8 | |
| Appendix | 6.9 | |
| AtrioventricularNode | 4.25 | |
| BDCA4+_DentriticCells | 7.55 | |
| Bonemarrow | 5.3 | |
| BronchialEpithelialCells | 1015.4 | |
| CD105+_Endothelial | 11.1 | |
| CD14+_Monocytes | 12.2 | |
| CD19+_BCells(neg._sel.) | 5.1 | |
| CD33+_Myeloid | 61.15 | |
| CD34+ | 10.7 | |
| CD4+_Tcells | 5.2 | |
| CD56+_NKCells | 21.75 | |
| CD71+_EarlyErythroid | 6.35 | |
| CD8+_Tcells | 5 | |
| CardiacMyocytes | 19.8 | |
| Caudatenucleus | 4.7 | |
| Cerebellum | 6.85 | |
| CerebellumPeduncles | 7.8 | |
| CiliaryGanglion | 16.65 | |
| CingulateCortex | 7.4 | |
| Colorectaladenocarcinoma | 292.6 | |
| DorsalRootGanglion | 13.5 | |
| FetalThyroid | 7.9 | |
| Fetalbrain | 8.6 | |
| Fetalliver | 26.95 | |
| Fetallung | 165.8 | |
| GlobusPallidus | 5 | |
| Heart | 8.65 | |
| Hypothalamus | 13.15 | |
| Kidney | 6.5 | |
| Leukemia_chronicMyelogenousK-562 | 263.15 | |
| Leukemia_promyelocytic-HL-60 | 24.05 | |
| Leukemialymphoblastic(MOLT-4) | 157.15 | |
| Liver | 15.4 | |
| Lung | 87.6 | |
| Lymphnode | 7.1 | |
| Lymphoma_burkitts(Daudi) | 71.8 | |
| Lymphoma_burkitts(Raji) | 27.9 | |
| MedullaOblongata | 6.1 | |
| OccipitalLobe | 4.85 | |
| OlfactoryBulb | 10.55 | |
| Ovary | 25.7 | |
| Pancreas | 21.45 | |
| PancreaticIslet | 63.8 | |
| ParietalLobe | 8.65 | |
| Pituitary | 7.95 | |
| Placenta | 41.05 | |
| Pons | 7.9 | |
| PrefrontalCortex | 13.1 | |
| Prostate | 44.45 | |
| Salivarygland | 4.25 | |
| SkeletalMuscle | 7.2 | |
| Skin | 4.85 | |
| SmoothMuscle | 136.05 | |
| Spinalcord | 14.65 | |
| SubthalamicNucleus | 7.35 | |
| SuperiorCervicalGanglion | 6.55 | |
| TemporalLobe | 5.45 | |
| Testis | 7.15 | |
| TestisGermCell | 15.3 | |
| TestisIntersitial | 5.05 | |
| TestisLeydigCell | 8.3 | |
| TestisSeminiferousTubule | 4.7 | |
| Thalamus | 6.8 | |
| Thymus | 6.8 | |
| Thyroid | 7.95 | |
| Tongue | 14.2 | |
| Tonsil | 9.05 | |
| Trachea | 30.75 | |
| TrigeminalGanglion | 11.5 | |
| Uterus | 24.05 | |
| UterusCorpus | 19.05 | |
| WholeBlood | 6.05 | |
| Wholebrain | 8.1 | |
| colon | 73.05 | |
| pineal_day | 6 | |
| pineal_night | 5.94 | |
| retina | 34.875 | |
| small_intestine | 34.55 | |
- Probe name: A_23_P208595
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 3.35 ± 0.72 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 3.28 ± 1 | |
| Basal Part of Pons | 3.61 ± 0.6 | |
| Cerebellar Cortex | 4.12 ± 0.48 | |
| Cerebellar Nuclei | 3.57 ± 0.72 | |
| Claustrum | 3.8 ± 0.49 | |
| Epithalamus | 3.21 ± 0.93 | |
| Frontal Lobe | 3.9 ± 0.59 | |
| Globus Pallidus | 2.57 ± 0.43 | |
| Hypothalamus | 3.23 ± 0.49 | |
| Insula | 3.56 ± 0.41 | |
| Limbic Lobe | 3.52 ± 0.76 | |
| Mesencephalon | 3.58 ± 0.77 | |
| Myelencephalon | 3.67 ± 0.71 | |
| Occipital Lobe | 3.17 ± 0.9 | |
| Parietal Lobe | 3.45 ± 0.66 | |
| Pontine Tegmentum | 3.58 ± 0.82 | |
| Striatum | 2.51 ± 0.68 | |
| Subthalamus | 3.39 ± 1.04 | |
| Temporal Lobe | 3.58 ± 0.59 | |
| Thalamus | 3.68 ± 0.71 | |
| White Matter | 4.81 ± 0.49 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Ldlr | CB | Cerebellum | 2.88 | |
| 2.55 | | |||
| Ldlr | CTX | Cerebral cortex | 1.59 | |
| 1.24 | | |||
| Ldlr | HIP | Hippocampal region | 4.27 | |
| 2.6 | | |||
| Ldlr | HPF | Hippocampal formation | 3.8 | |
| 2.43 | | |||
| Ldlr | HY | Hypothalamus | 5.69 | |
| 3.56 | | |||
| Ldlr | LSX | Lateral septal complex | 1.2 | |
| 0.79 | | |||
| Ldlr | MB | Midbrain | 3.54 | |
| 2.65 | | |||
| Ldlr | MY | Medulla | 13.73 | |
| 10.75 | | |||
| Ldlr | OLF | Olfactory bulb | 3.27 | |
| 1.94 | | |||
| Ldlr | P | Pons | 10.81 | |
| 8.04 | | |||
| Ldlr | PAL | Pallidum | 1.98 | |
| 1.58 | | |||
| Ldlr | RHP | Retrohippocampal region | 2.86 | |
| 2.12 | | |||
| Ldlr | sAMY | Striatum-like amygdalar nuclei | 4.2 | |
| 3.25 | | |||
| Ldlr | STR | Striatum | 1.09 | |
| 0.78 | | |||
| Ldlr | STRd | Striatum dorsal region | 0.55 | |
| 0.4 | | |||
| Ldlr | STRv | Striatum ventral region | 1.52 | |
| 0.87 | | |||
| Ldlr | TH | Thalamus | 3.5 | |
| 2.27 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00011764 | 20 | 831 | 850 | TTEDEVHICHNQDGYSYPSR | Peptide Atlas |