AutismKB 2.0

Annotation Detail for LEPR


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Basic Information Top
Gene Symbol:LEPR ( CD295,DKFZp686B1731,OBR )
Gene Full Name: leptin receptor
Band: 1p31.3
Quick LinksEntrez ID:3953; OMIM: 601007; Uniprot ID:LEPR_HUMAN; ENSEMBL ID: ENSG00000116678; HGNC ID: 6554
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus16 / 56401228
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult45 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor8 / 26384530
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor17 / 96359176
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal79 / 336030723
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow7 / 48801143
brain21 / 110098919
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye1 / 2110544
heart3 / 8962633
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver28 / 207743134
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle6 / 10771555
nerve1 / 1576863
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate5 / 18934526
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach5 / 9661951
testis5 / 33044215
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea15 / 52413286
umbilical cord0 / 136800 
uterus7 / 23287830
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211354_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.75
Adipocyte5.65
AdrenalCortex6.2
Adrenalgland4.9
Amygdala5.9
Appendix6.4
AtrioventricularNode5.6
BDCA4+_DentriticCells6.05
Bonemarrow5.7
BronchialEpithelialCells5.65
CD105+_Endothelial7.85
CD14+_Monocytes6.1
CD19+_BCells(neg._sel.)5.9
CD33+_Myeloid7.4
CD34+7.3
CD4+_Tcells6
CD56+_NKCells6.5
CD71+_EarlyErythroid5.4
CD8+_Tcells5.45
CardiacMyocytes7.55
Caudatenucleus5.15
Cerebellum4.65
CerebellumPeduncles6.55
CiliaryGanglion6.05
CingulateCortex5.85
Colorectaladenocarcinoma5.7
DorsalRootGanglion4.7
FetalThyroid5.6
Fetalbrain5.7
Fetalliver11.35
Fetallung4.9
GlobusPallidus4.4
Heart7.65
Hypothalamus6.2
Kidney4.8
Leukemia_chronicMyelogenousK-5627.05
Leukemia_promyelocytic-HL-605.05
Leukemialymphoblastic(MOLT-4)4.65
Liver8.45
Lung6.2
Lymphnode4.95
Lymphoma_burkitts(Daudi)7.4
Lymphoma_burkitts(Raji)8.1
MedullaOblongata5.2
OccipitalLobe5
OlfactoryBulb4.5
Ovary4.05
Pancreas4.65
PancreaticIslet6.05
ParietalLobe6.15
Pituitary6.85
Placenta5.7
Pons5.5
PrefrontalCortex6.75
Prostate6.5
Salivarygland4.65
SkeletalMuscle7.55
Skin5.2
SmoothMuscle6.55
Spinalcord6.15
SubthalamicNucleus5.4
SuperiorCervicalGanglion10.15
TemporalLobe5.25
Testis4.9
TestisGermCell4.7
TestisIntersitial4.85
TestisLeydigCell5.7
TestisSeminiferousTubule4.9
Thalamus5.8
Thymus4.3
Thyroid6.85
Tongue6
Tonsil5.55
Trachea5.35
TrigeminalGanglion6.95
Uterus4.7
UterusCorpus5.4
WholeBlood6.15
Wholebrain4.6
colon5.7
pineal_day7.14
pineal_night7.02
retina6.9
small_intestine5.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P231104
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.64 ± 1.1
Basal Forebrain2.12 ± 0.23
Basal Part of Pons1.94 ± 0.37
Cerebellar Cortex1.89 ± 0.43
Cerebellar Nuclei2.61 ± 0.66
Claustrum2.72 ± 0.67
Epithalamus2.01 ± 0.71
Frontal Lobe2.19 ± 0.72
Globus Pallidus3.1 ± 0.77
Hypothalamus2.19 ± 0.69
Insula2.01 ± 0.62
Limbic Lobe2.24 ± 0.69
Mesencephalon2.44 ± 0.73
Myelencephalon2.33 ± 0.7
Occipital Lobe2.25 ± 0.66
Parietal Lobe2.22 ± 0.62
Pontine Tegmentum2.28 ± 0.71
Striatum2.79 ± 0.59
Subthalamus2.43 ± 0.73
Temporal Lobe2.15 ± 0.69
Thalamus2.27 ± 0.62
White Matter2.36 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LeprCBCerebellum2.27
4.04
LeprCTXCerebral cortex5.84
4.13
LeprHIPHippocampal region2.12
2.46
LeprHPFHippocampal formation1.89
2.27
LeprHYHypothalamus4.2
3.44
LeprLSXLateral septal complex1.5
1.12
LeprMBMidbrain3.32
3.77
LeprMYMedulla4.94
5.35
LeprOLFOlfactory bulb3.09
2.62
LeprPPons2.21
2.72
LeprPALPallidum0.32
0.36
LeprRHPRetrohippocampal region1.34
1.32
LeprsAMYStriatum-like amygdalar nuclei0.86
1.14
LeprSTRStriatum1.32
1.45
LeprSTRdStriatum dorsal region1.63
1.86
LeprSTRvStriatum ventral region0.3
0.27
LeprTHThalamus1.56
2.06
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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