AutismKB 2.0

Annotation Detail for LGALS1


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Basic Information Top
Gene Symbol:LGALS1 ( DKFZp686E23103,GAL1,GBP )
Gene Full Name: lectin, galactoside-binding, soluble, 1
Band: 22q13.1
Quick LinksEntrez ID:3956; OMIM: 150570; Uniprot ID:LEG1_HUMAN; ENSEMBL ID: ENSG00000100097; HGNC ID: 6561
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst1 / 6231916
fetus109 / 564012193
neonate18 / 31097578
infant2 / 2362084
juvenile3 / 5555653
adult303 / 1939121156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma0 / 174750 
breast (mammary gland) tumor22 / 94178233
cervical tumor1 / 3436629
chondrosarcoma28 / 82823338
colorectal tumor3 / 11424626
esophageal tumor2 / 17290115
gastrointestinal tumor9 / 11936975
germ cell tumor14 / 26384553
glioma96 / 106883898
head and neck tumor24 / 136302176
kidney tumor28 / 68959406
leukemia2 / 9584220
liver tumor12 / 96359124
lung tumor20 / 103127193
lymphoma0 / 717550 
non-neoplasia13 / 97250133
normal607 / 3360307180
ovarian tumor5 / 7668265
pancreatic tumor20 / 104616191
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer15 / 102680146
retinoblastoma0 / 463560 
skin tumor76 / 124949608
soft tissue/muscle tissue tumor31 / 125191247
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland5 / 33197150
ascites1 / 4001524
bladder0 / 297570 
blood11 / 12347889
bone16 / 71655223
bone marrow12 / 48801245
brain168 / 1100989152
cervix3 / 4817162
connective tissue22 / 149255147
ear2 / 16212123
embryonic tissue24 / 215722111
esophagus2 / 2020998
eye49 / 211054232
heart43 / 89626479
intestine20 / 23447285
kidney45 / 211777212
larynx1 / 2414541
liver34 / 207743163
lung96 / 336974284
lymph0 / 442700 
lymph node3 / 9161032
mammary gland52 / 153271339
mouth5 / 6705274
muscle42 / 107715389
nerve3 / 15768190
ovary17 / 102051166
pancreas27 / 214812125
parathyroid1 / 2053948
pharynx6 / 41328145
pituitary gland4 / 16585241
placenta16 / 28082556
prostate47 / 189345248
salivary gland19 / 20155942
skin113 / 210574536
spleen2 / 5395237
stomach7 / 9661972
testis18 / 33044254
thymus2 / 8113124
thyroid2 / 4747342
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord18 / 136801315
uterus35 / 232878150
vascular35 / 51780675
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201105_at
Cell line Expression level Expression bar
721_B_lymphoblasts3763.85
Adipocyte5556.45
AdrenalCortex480.95
Adrenalgland795.65
Amygdala148.95
Appendix2143.95
AtrioventricularNode537.25
BDCA4+_DentriticCells1173.65
Bonemarrow431.1
BronchialEpithelialCells7910
CD105+_Endothelial98.3
CD14+_Monocytes2599.15
CD19+_BCells(neg._sel.)287.4
CD33+_Myeloid3326.8
CD34+718.95
CD4+_Tcells189.35
CD56+_NKCells1322.05
CD71+_EarlyErythroid15.55
CD8+_Tcells148.2
CardiacMyocytes8226.45
Caudatenucleus140.8
Cerebellum142.1
CerebellumPeduncles296.5
CiliaryGanglion772.45
CingulateCortex396.85
Colorectaladenocarcinoma3129.65
DorsalRootGanglion1669.75
FetalThyroid567.5
Fetalbrain130.65
Fetalliver71.25
Fetallung1422.95
GlobusPallidus158.8
Heart6228.1
Hypothalamus952.45
Kidney103.45
Leukemia_chronicMyelogenousK-562518.6
Leukemia_promyelocytic-HL-605.5
Leukemialymphoblastic(MOLT-4)6.25
Liver1298.75
Lung2772.65
Lymphnode637.1
Lymphoma_burkitts(Daudi)9.65
Lymphoma_burkitts(Raji)11.4
MedullaOblongata310.55
OccipitalLobe367.55
OlfactoryBulb2066.05
Ovary1033.8
Pancreas174.95
PancreaticIslet136.2
ParietalLobe379.4
Pituitary323
Placenta1124.5
Pons226.95
PrefrontalCortex769.25
Prostate1567.75
Salivarygland200.2
SkeletalMuscle523.4
Skin367.1
SmoothMuscle12232.9
Spinalcord2179.65
SubthalamicNucleus231.8
SuperiorCervicalGanglion511.05
TemporalLobe500.65
Testis539.2
TestisGermCell1335.25
TestisIntersitial302.85
TestisLeydigCell343.8
TestisSeminiferousTubule369.05
Thalamus1012.35
Thymus602.65
Thyroid505.1
Tongue542.9
Tonsil324.55
Trachea459.5
TrigeminalGanglion936.15
Uterus5587.4
UterusCorpus5443.75
WholeBlood1319.65
Wholebrain1371.8
colon1136.65
pineal_day335.68
pineal_night357.82
retina1647.675
small_intestine1607.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P44139
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.57 ± 0.33
Basal Forebrain6.12 ± 0.33
Basal Part of Pons6.92 ± 0.26
Cerebellar Cortex5.52 ± 0.4
Cerebellar Nuclei7.18 ± 0.3
Claustrum5.96 ± 0.69
Epithalamus5.96 ± 0.49
Frontal Lobe6.61 ± 0.56
Globus Pallidus7.01 ± 0.53
Hypothalamus6.42 ± 0.51
Insula5.9 ± 0.34
Limbic Lobe5.62 ± 0.67
Mesencephalon6 ± 0.74
Myelencephalon6.15 ± 0.66
Occipital Lobe5.46 ± 0.58
Parietal Lobe6.34 ± 0.46
Pontine Tegmentum6.19 ± 0.51
Striatum5.46 ± 0.77
Subthalamus6.84 ± 0.22
Temporal Lobe5.9 ± 0.53
Thalamus6.66 ± 0.51
White Matter6.46 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lgals1CBCerebellum2.02
2.79
Lgals1CTXCerebral cortex12.11
9.35
Lgals1HIPHippocampal region7.19
11.31
Lgals1HPFHippocampal formation8.15
8.45
Lgals1HYHypothalamus0.09
0.06
Lgals1LSXLateral septal complex3.15
2.64
Lgals1MBMidbrain2.22
3.02
Lgals1MYMedulla10.62
22.8
Lgals1OLFOlfactory bulb7.66
5.1
Lgals1PPons5.47
9.21
Lgals1PALPallidum0.64
0.7
Lgals1RHPRetrohippocampal region8.83
5.64
Lgals1sAMYStriatum-like amygdalar nuclei0.45
0.53
Lgals1STRStriatum1.37
1.21
Lgals1STRdStriatum dorsal region0.98
0.85
Lgals1STRvStriatum ventral region2.47
2.17
Lgals1THThalamus3.13
3.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LEG1_HUMAN_0 0 0 0 DSNNLCLHFNPR PRIDE
LEG1_HUMAN_0 0 0 0 FNAHGDANTIVCNSK PRIDE
LEG1_HUMAN_0 0 0 0 LNLEAINYMAADGDFK PRIDE
LEG1_HUMAN_0 0 0 0 LPDGYEFK PRIDE
LEG1_HUMAN_0 0 0 0 LPDGYEFKFPNR PRIDE
LEG1_HUMAN_1 18 1 18 ACGLVASNLNLKPGECLR PRIDE
LEG1_HUMAN_100 12 100 111 LPDGYEFKFPNR PRIDE
LEG1_HUMAN_100 8 100 107 LPDGYEFK PRIDE
LEG1_HUMAN_101 8 101 108 LPDGYEFK PRIDE
LEG1_HUMAN_108 20 108 127 FPNRLNLEAINYMAADGDFK PRIDE
LEG1_HUMAN_112 16 112 127 LNLEAINYMAADGDFK PRIDE
LEG1_HUMAN_112 18 112 129 LNLEAINYMAADGDFKIK PRIDE
LEG1_HUMAN_19 10 19 28 VRGEVAPDAK PRIDE
LEG1_HUMAN_22 8 22 29 GEVAPDAK PRIDE
LEG1_HUMAN_29 20 29 48 SFVLNLGKDSNNLCLHFNPR PRIDE
LEG1_HUMAN_30 8 30 37 SFVLNLGK PRIDE
LEG1_HUMAN_37 12 37 48 DSNNLCLHFNPR PRIDE
LEG1_HUMAN_38 12 38 49 DSNNLCLHFNPR PRIDE
LEG1_HUMAN_49 15 49 63 FNAHGDANTIVCNSK PRIDE
LEG1_HUMAN_49 25 49 73 FNAHGDANTIVCNSKDGGAWGTEQR PRIDE
LEG1_HUMAN_50 15 50 64 FNAHGDANTIVCNSK PRIDE
LEG1_HUMAN_64 10 64 73 DGGAWGTEQR PRIDE
PAp00001801 12 38 49 DSNNLCLHFNPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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