AutismKB 2.0

Annotation Detail for LGALS3


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Basic Information Top
Gene Symbol:LGALS3 ( CBP35,GAL3,GALBP,GALIG,L31,LGALS2,MAC2 )
Gene Full Name: lectin, galactoside-binding, soluble, 3
Band: 14q22.3
Quick LinksEntrez ID:3958; OMIM: 153619; Uniprot ID:LEG3_HUMAN; ENSEMBL ID: ENSG00000131981; HGNC ID: 6563
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus46 / 56401281
neonate1 / 3109732
infant1 / 2362042
juvenile0 / 555560 
adult241 / 1939121124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor31 / 94178329
cervical tumor6 / 34366174
chondrosarcoma15 / 82823181
colorectal tumor35 / 114246306
esophageal tumor3 / 17290173
gastrointestinal tumor13 / 119369108
germ cell tumor12 / 26384545
glioma11 / 106883102
head and neck tumor8 / 13630258
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor7 / 9635972
lung tumor47 / 103127455
lymphoma0 / 717550 
non-neoplasia21 / 97250215
normal271 / 336030780
ovarian tumor10 / 76682130
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor119 / 124949952
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor22 / 90257243
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland1 / 3319730
ascites10 / 40015249
bladder6 / 29757201
blood6 / 12347848
bone13 / 71655181
bone marrow1 / 4880120
brain26 / 110098923
cervix6 / 48171124
connective tissue14 / 14925593
ear1 / 1621261
embryonic tissue6 / 21572227
esophagus3 / 20209148
eye26 / 211054123
heart10 / 89626111
intestine69 / 234472294
kidney15 / 21177770
larynx0 / 241450 
liver18 / 20774386
lung102 / 336974302
lymph0 / 442700 
lymph node0 / 916100 
mammary gland35 / 153271228
mouth1 / 6705214
muscle9 / 10771583
nerve0 / 157680 
ovary13 / 102051127
pancreas21 / 21481297
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta30 / 280825106
prostate13 / 18934568
salivary gland7 / 20155347
skin134 / 210574636
spleen1 / 5395218
stomach10 / 96619103
testis10 / 33044230
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus33 / 232878141
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208949_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts25.45
Adipocyte3303.5
AdrenalCortex331.55
Adrenalgland351.85
Amygdala228.1
Appendix1395.35
AtrioventricularNode321.45
BDCA4+_DentriticCells727.8
Bonemarrow1127.65
BronchialEpithelialCells2483.55
CD105+_Endothelial1653.2
CD14+_Monocytes2963.3
CD19+_BCells(neg._sel.)61.25
CD33+_Myeloid2420.3
CD34+18.05
CD4+_Tcells51.75
CD56+_NKCells564.4
CD71+_EarlyErythroid6044.45
CD8+_Tcells34.75
CardiacMyocytes531.2
Caudatenucleus70.95
Cerebellum170.2
CerebellumPeduncles332.35
CiliaryGanglion473.9
CingulateCortex167.65
Colorectaladenocarcinoma1484.8
DorsalRootGanglion475
FetalThyroid847.35
Fetalbrain102.9
Fetalliver22.15
Fetallung898.8
GlobusPallidus76.95
Heart1477.1
Hypothalamus250.35
Kidney267.6
Leukemia_chronicMyelogenousK-562118.05
Leukemia_promyelocytic-HL-6014.6
Leukemialymphoblastic(MOLT-4)7.65
Liver50.45
Lung4450.2
Lymphnode929.65
Lymphoma_burkitts(Daudi)27.25
Lymphoma_burkitts(Raji)9.6
MedullaOblongata112.7
OccipitalLobe159.35
OlfactoryBulb1457.7
Ovary777.2
Pancreas2365.15
PancreaticIslet717.45
ParietalLobe124.55
Pituitary526.6
Placenta1547.55
Pons127.25
PrefrontalCortex540.4
Prostate2353.7
Salivarygland1159.35
SkeletalMuscle159.2
Skin1779.55
SmoothMuscle1347.2
Spinalcord378.15
SubthalamicNucleus164.65
SuperiorCervicalGanglion410.25
TemporalLobe308.45
Testis469.75
TestisGermCell1226.8
TestisIntersitial483.25
TestisLeydigCell402.6
TestisSeminiferousTubule478.25
Thalamus169.25
Thymus556.15
Thyroid689.25
Tongue2624.65
Tonsil989.75
Trachea1918.4
TrigeminalGanglion586.2
Uterus1782.45
UterusCorpus1615.1
WholeBlood1007.15
Wholebrain316.55
colon11795.75
pineal_day166.98
pineal_night173
retina1018
small_intestine5360.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P128919
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.2 ± 0.26
Basal Forebrain9.11 ± 0.42
Basal Part of Pons8.29 ± 0.31
Cerebellar Cortex9.34 ± 0.37
Cerebellar Nuclei8.66 ± 0.21
Claustrum8.42 ± 0.58
Epithalamus9.47 ± 0.31
Frontal Lobe9.04 ± 0.41
Globus Pallidus8.69 ± 0.24
Hypothalamus9.07 ± 0.39
Insula9.23 ± 0.31
Limbic Lobe8.94 ± 0.48
Mesencephalon9.03 ± 0.28
Myelencephalon9.04 ± 0.43
Occipital Lobe9.13 ± 0.38
Parietal Lobe9.03 ± 0.44
Pontine Tegmentum9.11 ± 0.38
Striatum8.79 ± 0.31
Subthalamus8.72 ± 0.1
Temporal Lobe9.07 ± 0.35
Thalamus9.23 ± 0.41
White Matter7.74 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lgals3CBCerebellum2.02
2.09
Lgals3CTXCerebral cortex0.89
1.08
Lgals3HIPHippocampal region0.64
0.85
Lgals3HPFHippocampal formation0.55
0.7
Lgals3HYHypothalamus0.52
0.62
Lgals3LSXLateral septal complex0.3
0.37
Lgals3MBMidbrain0.36
0.53
Lgals3MYMedulla1.49
1.84
Lgals3OLFOlfactory bulb1.67
1.39
Lgals3PPons0.37
0.54
Lgals3PALPallidum0.08
0.06
Lgals3RHPRetrohippocampal region0.43
0.5
Lgals3sAMYStriatum-like amygdalar nuclei0.1
0.07
Lgals3STRStriatum0.37
0.32
Lgals3STRdStriatum dorsal region0.44
0.4
Lgals3STRvStriatum ventral region0.36
0.21
Lgals3THThalamus0.22
0.2
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LEG3_HUMAN_0 0 0 0 GNDVAFHFNPR PRIDE
LEG3_HUMAN_0 0 0 0 IQVLVEPDHFK PRIDE
LEG3_HUMAN_0 0 0 0 MLITILGTVKPNANR PRIDE
LEG3_HUMAN_0 0 0 0 VAVNDAHLLQYNHR PRIDE
LEG3_HUMAN_129 15 129 143 MLITILGTVKPNANR PRIDE
LEG3_HUMAN_144 7 144 150 IALDFQR PRIDE
LEG3_HUMAN_151 11 151 161 GNDVAFHFNPR PRIDE
LEG3_HUMAN_169 17 169 185 VIVCNTKLDNNWGREER PRIDE
LEG3_HUMAN_186 13 186 198 QSVFPFESGKPFK PRIDE
LEG3_HUMAN_199 11 199 209 IQVLVEPDHFK PRIDE
LEG3_HUMAN_210 14 210 223 VAVNDAHLLQYNHR PRIDE
PAp00036259 15 130 144 MLITILGTVKPNANR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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