AutismKB 2.0

Annotation Detail for LHX1


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Basic Information Top
Gene Symbol:LHX1 ( LIM-1,LIM1,MGC126723,MGC138141 )
Gene Full Name: LIM homeobox 1
Band: 17q12
Quick LinksEntrez ID:3975; OMIM: 601999; Uniprot ID:LHX1_HUMAN; ENSEMBL ID: ENSG00000132130; HGNC ID: 6593
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst13 / 62319208
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult6 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal42 / 336030712
ovarian tumor6 / 7668278
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain11 / 11009899
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney12 / 21177756
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary8 / 10205178
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206230_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.25
Adipocyte6.45
AdrenalCortex7.75
Adrenalgland5.65
Amygdala6.85
Appendix6.65
AtrioventricularNode5.5
BDCA4+_DentriticCells7.3
Bonemarrow7.05
BronchialEpithelialCells6.5
CD105+_Endothelial6.5
CD14+_Monocytes7.05
CD19+_BCells(neg._sel.)7
CD33+_Myeloid7.75
CD34+8.05
CD4+_Tcells6.85
CD56+_NKCells7.5
CD71+_EarlyErythroid6.1
CD8+_Tcells5.65
CardiacMyocytes10.8
Caudatenucleus5.85
Cerebellum5.35
CerebellumPeduncles10.65
CiliaryGanglion4.95
CingulateCortex6.75
Colorectaladenocarcinoma6.5
DorsalRootGanglion5
FetalThyroid6.35
Fetalbrain6.4
Fetalliver5.6
Fetallung5.1
GlobusPallidus4.85
Heart8.4
Hypothalamus7.1
Kidney6.45
Leukemia_chronicMyelogenousK-5625.9
Leukemia_promyelocytic-HL-605.75
Leukemialymphoblastic(MOLT-4)5.25
Liver9.05
Lung7.05
Lymphnode5.45
Lymphoma_burkitts(Daudi)8.4
Lymphoma_burkitts(Raji)9.2
MedullaOblongata6
OccipitalLobe5.85
OlfactoryBulb5.1
Ovary4.4
Pancreas5.25
PancreaticIslet6.95
ParietalLobe6.85
Pituitary7.6
Placenta6.55
Pons6.4
PrefrontalCortex7.95
Prostate7.35
Salivarygland5.4
SkeletalMuscle8.35
Skin5.15
SmoothMuscle7.25
Spinalcord6.95
SubthalamicNucleus5.95
SuperiorCervicalGanglion10.7
TemporalLobe6
Testis5.6
TestisGermCell5.55
TestisIntersitial5.55
TestisLeydigCell7.35
TestisSeminiferousTubule5.6
Thalamus6.7
Thymus5.1
Thyroid7.7
Tongue7.05
Tonsil6.35
Trachea5.45
TrigeminalGanglion7
Uterus5
UterusCorpus6.2
WholeBlood6.95
Wholebrain5.45
colon6.55
pineal_day8.1
pineal_night7.98
retina7.9
small_intestine6.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P78061
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.52 ± 0.83
Basal Forebrain6.31 ± 0.31
Basal Part of Pons6.96 ± 0.27
Cerebellar Cortex7.37 ± 0.5
Cerebellar Nuclei6.93 ± 0.3
Claustrum7.03 ± 0.82
Epithalamus5.78 ± 0.46
Frontal Lobe6.41 ± 0.67
Globus Pallidus6.75 ± 1.17
Hypothalamus6.86 ± 0.94
Insula6.48 ± 0.52
Limbic Lobe6.44 ± 0.68
Mesencephalon7.05 ± 0.8
Myelencephalon6.59 ± 0.72
Occipital Lobe6.74 ± 0.77
Parietal Lobe6.47 ± 0.66
Pontine Tegmentum6.32 ± 0.57
Striatum6.04 ± 0.61
Subthalamus6.4 ± 0.14
Temporal Lobe6.39 ± 0.7
Thalamus6.45 ± 0.55
White Matter6.57 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lhx1CBCerebellum21.78
48.1
Lhx1CTXCerebral cortex0.34
0.36
Lhx1HIPHippocampal region0.51
0.79
Lhx1HPFHippocampal formation0.39
0.62
Lhx1HYHypothalamus1.11
1.12
Lhx1LSXLateral septal complex0.22
0.18
Lhx1MBMidbrain1.38
1.51
Lhx1MYMedulla1.78
1.61
Lhx1OLFOlfactory bulb1.05
1.65
Lhx1PPons0.41
0.47
Lhx1PALPallidum0.23
0.2
Lhx1RHPRetrohippocampal region0.26
0.46
Lhx1sAMYStriatum-like amygdalar nuclei0.17
0.16
Lhx1STRStriatum0.24
0.2
Lhx1STRdStriatum dorsal region0.24
0.2
Lhx1STRvStriatum ventral region0.27
0.21
Lhx1THThalamus0.42
0.48
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LHX1_HUMAN_174 8 174 181 QNLGAKRR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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