AutismKB 2.0

Annotation Detail for LIFR


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Basic Information Top
Gene Symbol:LIFR ( CD118,FLJ98106,FLJ99923,LIF-R,SJS2,STWS,SWS )
Gene Full Name: leukemia inhibitory factor receptor alpha
Band: 5p13.1
Quick LinksEntrez ID:3977; OMIM: 151443; Uniprot ID:LIFR_HUMAN; ENSEMBL ID: ENSG00000113594; HGNC ID: 6597
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst5 / 6231980
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult98 / 193912150
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor4 / 26384515
glioma5 / 10688346
head and neck tumor10 / 13630273
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal169 / 336030750
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain25 / 110098922
cervix0 / 481710 
connective tissue5 / 14925533
ear2 / 16212123
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye5 / 21105423
heart4 / 8962644
intestine2 / 2344728
kidney11 / 21177751
larynx3 / 24145124
liver8 / 20774338
lung16 / 33697447
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle16 / 107715148
nerve2 / 15768126
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta32 / 280825113
prostate10 / 18934552
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach1 / 9661910
testis6 / 33044218
thymus2 / 8113124
thyroid6 / 47473126
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus10 / 23287842
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205876_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.2
Adipocyte7.3
AdrenalCortex10.25
Adrenalgland6.8
Amygdala7.4
Appendix9.55
AtrioventricularNode8.4
BDCA4+_DentriticCells7.25
Bonemarrow8.7
BronchialEpithelialCells7.05
CD105+_Endothelial8
CD14+_Monocytes8.15
CD19+_BCells(neg._sel.)7.6
CD33+_Myeloid9
CD34+8.75
CD4+_Tcells7.55
CD56+_NKCells8.25
CD71+_EarlyErythroid7.45
CD8+_Tcells6.55
CardiacMyocytes14.55
Caudatenucleus6.9
Cerebellum6.2
CerebellumPeduncles9.45
CiliaryGanglion7
CingulateCortex8.05
Colorectaladenocarcinoma7.5
DorsalRootGanglion7.65
FetalThyroid9.05
Fetalbrain7.15
Fetalliver6.8
Fetallung6
GlobusPallidus6.3
Heart13.6
Hypothalamus7.65
Kidney7.2
Leukemia_chronicMyelogenousK-5626.65
Leukemia_promyelocytic-HL-606.55
Leukemialymphoblastic(MOLT-4)5.7
Liver12.15
Lung8.05
Lymphnode6.1
Lymphoma_burkitts(Daudi)10.15
Lymphoma_burkitts(Raji)12.25
MedullaOblongata6.6
OccipitalLobe6.7
OlfactoryBulb5.8
Ovary5.9
Pancreas6.7
PancreaticIslet8.35
ParietalLobe8.9
Pituitary8.8
Placenta11.6
Pons7.65
PrefrontalCortex8.85
Prostate8.7
Salivarygland6.55
SkeletalMuscle13.25
Skin7.55
SmoothMuscle8.5
Spinalcord7.95
SubthalamicNucleus7.4
SuperiorCervicalGanglion14.1
TemporalLobe7.25
Testis6.4
TestisGermCell5.9
TestisIntersitial6.6
TestisLeydigCell8.1
TestisSeminiferousTubule6.35
Thalamus8
Thymus5.6
Thyroid10.25
Tongue8.95
Tonsil7.4
Trachea6.3
TrigeminalGanglion12.2
Uterus8.7
UterusCorpus8.1
WholeBlood8
Wholebrain5.85
colon7.5
pineal_day9.26
pineal_night9.16
retina9.325
small_intestine7.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P397386
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.99 ± 0.38
Basal Forebrain7.28 ± 0.22
Basal Part of Pons7.32 ± 0.2
Cerebellar Cortex6.35 ± 0.27
Cerebellar Nuclei7.1 ± 0.48
Claustrum6.58 ± 0.34
Epithalamus7.41 ± 0.3
Frontal Lobe6.68 ± 0.52
Globus Pallidus8.34 ± 0.48
Hypothalamus7.08 ± 0.48
Insula6.6 ± 0.3
Limbic Lobe6.48 ± 0.61
Mesencephalon7.14 ± 0.44
Myelencephalon6.92 ± 0.48
Occipital Lobe7.21 ± 0.53
Parietal Lobe6.89 ± 0.43
Pontine Tegmentum6.73 ± 0.41
Striatum7.58 ± 0.51
Subthalamus6.85 ± 0.06
Temporal Lobe6.59 ± 0.4
Thalamus7.22 ± 0.41
White Matter8.29 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LifrCBCerebellum14.93
20.47
LifrCTXCerebral cortex56.24
54.05
LifrHIPHippocampal region39.87
68.23
LifrHPFHippocampal formation44.88
61.17
LifrHYHypothalamus8.27
8.28
LifrLSXLateral septal complex2.64
2.04
LifrMBMidbrain21.09
24.74
LifrMYMedulla41.01
72.21
LifrOLFOlfactory bulb34.49
32.39
LifrPPons33.63
53.07
LifrPALPallidum8.58
8.93
LifrRHPRetrohippocampal region55.67
55.73
LifrsAMYStriatum-like amygdalar nuclei11.71
10.53
LifrSTRStriatum4.43
3.67
LifrSTRdStriatum dorsal region3.28
2.71
LifrSTRvStriatum ventral region5.25
3.76
LifrTHThalamus11.93
15.81
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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