AutismKB 2.0

Annotation Detail for LIG3


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Basic Information Top
Gene Symbol:LIG3 ( LIG2 )
Gene Full Name: ligase III, DNA, ATP-dependent
Band: 17q12
Quick LinksEntrez ID:3980; OMIM: 600940; Uniprot ID:DNLI3_HUMAN; ENSEMBL ID: ENSG00000005156; HGNC ID: 6600
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst5 / 6231980
fetus28 / 56401249
neonate1 / 3109732
infant0 / 236200 
juvenile5 / 5555689
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor2 / 3436658
chondrosarcoma2 / 8282324
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor7 / 26384526
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal123 / 336030736
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer7 / 10268068
retinoblastoma2 / 4635643
skin tumor6 / 12494948
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites2 / 4001549
bladder2 / 2975767
blood9 / 12347872
bone2 / 7165527
bone marrow7 / 48801143
brain30 / 110098927
cervix6 / 48171124
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine6 / 23447225
kidney7 / 21177733
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph1 / 4427022
lymph node2 / 9161021
mammary gland9 / 15327158
mouth3 / 6705244
muscle6 / 10771555
nerve0 / 157680 
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta14 / 28082549
prostate9 / 18934547
salivary gland0 / 201550 
skin8 / 21057437
spleen2 / 5395237
stomach1 / 9661910
testis34 / 330442102
thymus5 / 8113161
thyroid2 / 4747342
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord2 / 13680146
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207348_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.6
Adipocyte5.25
AdrenalCortex5.8
Adrenalgland4.55
Amygdala5.45
Appendix5.65
AtrioventricularNode4.2
BDCA4+_DentriticCells6.25
Bonemarrow6.05
BronchialEpithelialCells4.95
CD105+_Endothelial5.25
CD14+_Monocytes6.45
CD19+_BCells(neg._sel.)5.5
CD33+_Myeloid6.7
CD34+8.95
CD4+_Tcells5.65
CD56+_NKCells6.3
CD71+_EarlyErythroid5.05
CD8+_Tcells5.1
CardiacMyocytes7.8
Caudatenucleus4.65
Cerebellum4.3
CerebellumPeduncles6.15
CiliaryGanglion3.9
CingulateCortex5.45
Colorectaladenocarcinoma5.35
DorsalRootGanglion4.2
FetalThyroid5.8
Fetalbrain5.25
Fetalliver4.65
Fetallung4.35
GlobusPallidus3.9
Heart7.15
Hypothalamus5.8
Kidney4.3
Leukemia_chronicMyelogenousK-5625.5
Leukemia_promyelocytic-HL-604.75
Leukemialymphoblastic(MOLT-4)7.95
Liver7.25
Lung5.8
Lymphnode4.5
Lymphoma_burkitts(Daudi)6.9
Lymphoma_burkitts(Raji)7.55
MedullaOblongata4.85
OccipitalLobe4.7
OlfactoryBulb4.1
Ovary3.6
Pancreas4.4
PancreaticIslet5.85
ParietalLobe5.85
Pituitary7.15
Placenta6.95
Pons5.25
PrefrontalCortex6.2
Prostate6.15
Salivarygland4.45
SkeletalMuscle6.4
Skin4.25
SmoothMuscle6.8
Spinalcord5.7
SubthalamicNucleus4.9
SuperiorCervicalGanglion6.35
TemporalLobe6.85
Testis7.85
TestisGermCell8.1
TestisIntersitial7.95
TestisLeydigCell8.1
TestisSeminiferousTubule4.95
Thalamus5.5
Thymus4.4
Thyroid6.65
Tongue5.95
Tonsil5.2
Trachea4.5
TrigeminalGanglion6.85
Uterus4.2
UterusCorpus8.15
WholeBlood5.8
Wholebrain4.35
colon5.15
pineal_day6.56
pineal_night6.32
retina6.1
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P119519
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.34 ± 0.4
Basal Forebrain7.06 ± 0.24
Basal Part of Pons6.79 ± 0.23
Cerebellar Cortex7.26 ± 0.21
Cerebellar Nuclei6.9 ± 0.21
Claustrum7.25 ± 0.34
Epithalamus6.9 ± 0.43
Frontal Lobe6.87 ± 0.31
Globus Pallidus6.92 ± 0.12
Hypothalamus6.78 ± 0.26
Insula6.95 ± 0.33
Limbic Lobe7.03 ± 0.29
Mesencephalon6.98 ± 0.27
Myelencephalon6.97 ± 0.29
Occipital Lobe7.13 ± 0.32
Parietal Lobe6.98 ± 0.29
Pontine Tegmentum7 ± 0.29
Striatum7.03 ± 0.33
Subthalamus6.84 ± 0.15
Temporal Lobe6.94 ± 0.26
Thalamus6.91 ± 0.26
White Matter7.27 ± 0.13
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lig3CBCerebellum35.67
63.31
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00024339 12 729 740 CAGGHDDATLAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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