AutismKB 2.0

Annotation Detail for LIMK1


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Basic Information Top
Gene Symbol:LIMK1 ( LIMK )
Gene Full Name: LIM domain kinase 1
Band: 7q11.23
Quick LinksEntrez ID:3984; OMIM: 601329; Uniprot ID:LIMK1_HUMAN; ENSEMBL ID: ENSG00000106683; HGNC ID: 6613
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus10 / 56401217
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult41 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma3 / 10688328
head and neck tumor3 / 13630222
kidney tumor7 / 68959101
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal91 / 336030727
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow0 / 488010 
brain57 / 110098951
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye8 / 21105437
heart1 / 8962611
intestine5 / 23447221
kidney7 / 21177733
larynx1 / 2414541
liver2 / 2077439
lung5 / 33697414
lymph0 / 442700 
lymph node5 / 9161054
mammary gland3 / 15327119
mouth1 / 6705214
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate3 / 18934515
salivary gland0 / 201550 
skin5 / 21057423
spleen2 / 5395237
stomach0 / 966190 
testis2 / 3304426
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208372_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.15
Adipocyte6.45
AdrenalCortex6.85
Adrenalgland5.55
Amygdala6.95
Appendix6.6
AtrioventricularNode5.05
BDCA4+_DentriticCells6.4
Bonemarrow6.95
BronchialEpithelialCells6.45
CD105+_Endothelial6.65
CD14+_Monocytes8.1
CD19+_BCells(neg._sel.)6.6
CD33+_Myeloid8.25
CD34+7.65
CD4+_Tcells8.25
CD56+_NKCells8.6
CD71+_EarlyErythroid6.2
CD8+_Tcells5.85
CardiacMyocytes8.5
Caudatenucleus5.9
Cerebellum5.25
CerebellumPeduncles7.95
CiliaryGanglion4.65
CingulateCortex6.75
Colorectaladenocarcinoma8.55
DorsalRootGanglion4.95
FetalThyroid7.75
Fetalbrain6.5
Fetalliver5.65
Fetallung5.3
GlobusPallidus4.85
Heart8.5
Hypothalamus6.6
Kidney6
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.8
Leukemialymphoblastic(MOLT-4)5.25
Liver8.95
Lung7.4
Lymphnode5.65
Lymphoma_burkitts(Daudi)9.25
Lymphoma_burkitts(Raji)11.1
MedullaOblongata6
OccipitalLobe5.95
OlfactoryBulb5.1
Ovary5.6
Pancreas5.6
PancreaticIslet8.55
ParietalLobe7
Pituitary7.75
Placenta6.45
Pons6.3
PrefrontalCortex11.95
Prostate7.6
Salivarygland5.45
SkeletalMuscle8.5
Skin5.35
SmoothMuscle7.55
Spinalcord7
SubthalamicNucleus6.1
SuperiorCervicalGanglion8.15
TemporalLobe6.1
Testis5.6
TestisGermCell5.5
TestisIntersitial5.7
TestisLeydigCell6.7
TestisSeminiferousTubule9.65
Thalamus6.55
Thymus4.75
Thyroid8.25
Tongue7.05
Tonsil6.35
Trachea5.45
TrigeminalGanglion6.5
Uterus5.35
UterusCorpus6.4
WholeBlood7.15
Wholebrain6.6
colon6.55
pineal_day8.24
pineal_night7.56
retina8
small_intestine6.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12204_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.28 ± 0.57
Basal Forebrain3.53 ± 0.76
Basal Part of Pons4.82 ± 0.38
Cerebellar Cortex3.8 ± 0.55
Cerebellar Nuclei4.27 ± 0.6
Claustrum4.47 ± 0.7
Epithalamus3.04 ± 0.85
Frontal Lobe4.21 ± 0.7
Globus Pallidus4.36 ± 0.68
Hypothalamus3.79 ± 0.47
Insula4 ± 0.59
Limbic Lobe4.16 ± 0.72
Mesencephalon4.05 ± 0.69
Myelencephalon4.1 ± 0.75
Occipital Lobe4.29 ± 0.57
Parietal Lobe4.46 ± 0.64
Pontine Tegmentum3.97 ± 0.61
Striatum2.9 ± 0.92
Subthalamus4.65 ± 0.43
Temporal Lobe4.13 ± 0.54
Thalamus4.29 ± 0.69
White Matter2.45 ± 1.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Limk1CBCerebellum5.89
10.11
Limk1CTXCerebral cortex5.45
5.29
Limk1HIPHippocampal region1.94
2.39
Limk1HPFHippocampal formation2.23
2.45
Limk1HYHypothalamus7.61
8.05
Limk1LSXLateral septal complex1.1
1.36
Limk1MBMidbrain17.21
21.69
Limk1MYMedulla35.03
58.05
Limk1OLFOlfactory bulb1.75
2.31
Limk1PPons39.72
57.9
Limk1PALPallidum12
15.69
Limk1RHPRetrohippocampal region2.61
2.46
Limk1sAMYStriatum-like amygdalar nuclei0.98
0.71
Limk1STRStriatum1.43
1.72
Limk1STRdStriatum dorsal region1.42
1.67
Limk1STRvStriatum ventral region1.82
2.36
Limk1THThalamus8.89
10.19
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp01141321 15 302 316 SPGAGSLGSPASQRK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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