AutismKB 2.0

Annotation Detail for ARL1


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Basic Information Top
Gene Symbol:ARL1 ( ARFL1 )
Gene Full Name: ADP-ribosylation factor-like 1
Band: 12q23.2
Quick LinksEntrez ID:400; OMIM: 603425; Uniprot ID:ARL1_HUMAN; ENSEMBL ID: ENSG00000120805; HGNC ID: 692
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst3 / 6231948
fetus54 / 56401295
neonate5 / 31097160
infant3 / 23620127
juvenile3 / 5555653
adult155 / 193912179
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor11 / 11424696
esophageal tumor1 / 1729057
gastrointestinal tumor8 / 11936967
germ cell tumor18 / 26384568
glioma2 / 10688318
head and neck tumor9 / 13630266
kidney tumor10 / 68959145
leukemia5 / 9584252
liver tumor11 / 96359114
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia8 / 9725082
normal301 / 336030789
ovarian tumor1 / 7668213
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer6 / 10268058
retinoblastoma1 / 4635621
skin tumor6 / 12494948
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder3 / 29757100
blood4 / 12347832
bone5 / 7165569
bone marrow2 / 4880140
brain71 / 110098964
cervix3 / 4817162
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus1 / 2020949
eye11 / 21105452
heart6 / 8962666
intestine22 / 23447293
kidney31 / 211777146
larynx2 / 2414582
liver20 / 20774396
lung21 / 33697462
lymph0 / 442700 
lymph node1 / 9161010
mammary gland10 / 15327165
mouth3 / 6705244
muscle8 / 10771574
nerve0 / 157680 
ovary1 / 1020519
pancreas29 / 214812135
parathyroid2 / 2053997
pharynx8 / 41328193
pituitary gland2 / 16585120
placenta30 / 280825106
prostate13 / 18934568
salivary gland2 / 2015599
skin20 / 21057494
spleen3 / 5395255
stomach9 / 9661993
testis38 / 330442114
thymus8 / 8113198
thyroid4 / 4747384
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord0 / 136800 
uterus19 / 23287881
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201657_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.2
Adipocyte11.9
AdrenalCortex20.05
Adrenalgland11
Amygdala12.1
Appendix19.85
AtrioventricularNode20.4
BDCA4+_DentriticCells14.3
Bonemarrow14.85
BronchialEpithelialCells11.35
CD105+_Endothelial13
CD14+_Monocytes12.8
CD19+_BCells(neg._sel.)11.35
CD33+_Myeloid14.25
CD34+14.05
CD4+_Tcells9.85
CD56+_NKCells13.65
CD71+_EarlyErythroid11.65
CD8+_Tcells9.35
CardiacMyocytes21.6
Caudatenucleus10.2
Cerebellum9.25
CerebellumPeduncles16.05
CiliaryGanglion15.5
CingulateCortex13
Colorectaladenocarcinoma10.85
DorsalRootGanglion12.1
FetalThyroid12.7
Fetalbrain9.95
Fetalliver10.5
Fetallung8.2
GlobusPallidus10.7
Heart20.3
Hypothalamus11.2
Kidney11.25
Leukemia_chronicMyelogenousK-56212.85
Leukemia_promyelocytic-HL-609.85
Leukemialymphoblastic(MOLT-4)8.25
Liver21.85
Lung11.75
Lymphnode9.7
Lymphoma_burkitts(Daudi)15.8
Lymphoma_burkitts(Raji)19.3
MedullaOblongata9.15
OccipitalLobe10.65
OlfactoryBulb9.45
Ovary11.4
Pancreas11.15
PancreaticIslet17.55
ParietalLobe14.25
Pituitary16.35
Placenta11.4
Pons12.2
PrefrontalCortex12.6
Prostate12.75
Salivarygland10.5
SkeletalMuscle22.65
Skin13.1
SmoothMuscle16.5
Spinalcord11.95
SubthalamicNucleus12.95
SuperiorCervicalGanglion26.3
TemporalLobe11.9
Testis9.1
TestisGermCell9.95
TestisIntersitial10.35
TestisLeydigCell13.6
TestisSeminiferousTubule9.7
Thalamus12.6
Thymus8
Thyroid14.75
Tongue16.9
Tonsil12
Trachea10.85
TrigeminalGanglion21.8
Uterus12.35
UterusCorpus15.25
WholeBlood11.35
Wholebrain7.7
colon33.7
pineal_day21.74
pineal_night28.18
retina14.8
small_intestine24
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P68586
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9 ± 0.19
Basal Forebrain8.86 ± 0.2
Basal Part of Pons9.11 ± 0.14
Cerebellar Cortex8.78 ± 0.23
Cerebellar Nuclei9.2 ± 0.27
Claustrum8.9 ± 0.29
Epithalamus9.1 ± 0.22
Frontal Lobe8.99 ± 0.23
Globus Pallidus8.82 ± 0.39
Hypothalamus9.21 ± 0.19
Insula8.9 ± 0.19
Limbic Lobe8.95 ± 0.26
Mesencephalon8.96 ± 0.31
Myelencephalon8.92 ± 0.26
Occipital Lobe8.92 ± 0.22
Parietal Lobe8.95 ± 0.25
Pontine Tegmentum8.95 ± 0.23
Striatum8.94 ± 0.21
Subthalamus9.11 ± 0.14
Temporal Lobe8.94 ± 0.2
Thalamus8.92 ± 0.17
White Matter8.9 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arl1CBCerebellum29.99
68.16
Arl1CTXCerebral cortex100
100
Arl1HIPHippocampal region100
100
Arl1HPFHippocampal formation100
100
Arl1HYHypothalamus64.66
58.95
Arl1LSXLateral septal complex89.63
80.41
Arl1MBMidbrain68.58
72.03
Arl1MYMedulla71.92
100
Arl1OLFOlfactory bulb82.88
90.28
Arl1PPons67.06
85.57
Arl1PALPallidum65.6
69.73
Arl1RHPRetrohippocampal region100
100
Arl1sAMYStriatum-like amygdalar nuclei100
100
Arl1STRStriatum81.29
69.91
Arl1STRdStriatum dorsal region85.1
73.26
Arl1STRvStriatum ventral region61.15
46.07
Arl1THThalamus75.49
76.74
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ARL1_HUMAN_104 13 104 116 SELVAMLEEEELR PRIDE
ARL1_HUMAN_105 13 105 117 SELVAMLEEEELR PRIDE
ARL1_HUMAN_105 14 105 118 SELVAMLEEEELRK PRIDE
ARL1_HUMAN_162 16 162 177 GTGLDEAMEWLVETLK PRIDE
ARL1_HUMAN_19 11 19 29 ILILGLDGAGK PRIDE
ARL1_HUMAN_20 11 20 30 ILILGLDGAGK PRIDE
ARL1_HUMAN_36 23 36 58 LQVGEVVTTIPTIGFNVETVTYK PRIDE
ARL1_HUMAN_99 18 99 116 IGISKSELVAMLEEEELR PRIDE
ARL1_HUMAN_99 19 99 117 IGISKSELVAMLEEEELRK PRIDE
PAp00034368 16 163 178 GTGLDEAMEWLVETLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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