AutismKB 2.0

Annotation Detail for PRICKLE3


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Basic Information Top
Gene Symbol:PRICKLE3 ( LMO6 )
Gene Full Name: prickle homolog 3 (Drosophila)
Band: Xp11.23
Quick LinksEntrez ID:4007; OMIM: 300111; Uniprot ID:PRIC3_HUMAN; ENSEMBL ID: ENSG00000012211; HGNC ID: 6645
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor3 / 11424626
esophageal tumor3 / 17290173
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor4 / 6895958
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor6 / 10312758
lymphoma4 / 7175555
non-neoplasia0 / 972500 
normal33 / 33603079
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow2 / 4880140
brain1 / 11009890 
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus3 / 20209148
eye1 / 2110544
heart0 / 896260 
intestine8 / 23447234
kidney4 / 21177718
larynx0 / 241450 
liver5 / 20774324
lung9 / 33697426
lymph4 / 4427090
lymph node1 / 9161010
mammary gland6 / 15327139
mouth3 / 6705244
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate3 / 18934515
salivary gland2 / 2015599
skin4 / 21057418
spleen1 / 5395218
stomach0 / 966190 
testis1 / 3304423
thymus6 / 8113173
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217349_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.65
Adipocyte4.15
AdrenalCortex4.5
Adrenalgland3.55
Amygdala4.25
Appendix4.35
AtrioventricularNode3.55
BDCA4+_DentriticCells4.75
Bonemarrow4.3
BronchialEpithelialCells4.4
CD105+_Endothelial4.1
CD14+_Monocytes4.5
CD19+_BCells(neg._sel.)4.4
CD33+_Myeloid5.85
CD34+5.4
CD4+_Tcells4.65
CD56+_NKCells4.8
CD71+_EarlyErythroid3.9
CD8+_Tcells4
CardiacMyocytes6.55
Caudatenucleus3.75
Cerebellum3.35
CerebellumPeduncles4.7
CiliaryGanglion3.35
CingulateCortex5.6
Colorectaladenocarcinoma6.45
DorsalRootGanglion3.35
FetalThyroid4.15
Fetalbrain4.2
Fetalliver3.5
Fetallung3.45
GlobusPallidus3.1
Heart5.4
Hypothalamus4.55
Kidney3.5
Leukemia_chronicMyelogenousK-5624.05
Leukemia_promyelocytic-HL-604.95
Leukemialymphoblastic(MOLT-4)3.45
Liver5.6
Lung4.8
Lymphnode3.65
Lymphoma_burkitts(Daudi)5.35
Lymphoma_burkitts(Raji)8.25
MedullaOblongata3.9
OccipitalLobe3.8
OlfactoryBulb3.25
Ovary2.8
Pancreas3.4
PancreaticIslet4.45
ParietalLobe4.55
Pituitary4.9
Placenta4.35
Pons3.95
PrefrontalCortex4.95
Prostate4.95
Salivarygland3.25
SkeletalMuscle5.95
Skin3.45
SmoothMuscle4.7
Spinalcord4.45
SubthalamicNucleus3.85
SuperiorCervicalGanglion5.05
TemporalLobe3.8
Testis3.6
TestisGermCell3.45
TestisIntersitial3.5
TestisLeydigCell5.15
TestisSeminiferousTubule4.1
Thalamus4.25
Thymus3.3
Thyroid5.65
Tongue4.25
Tonsil4.1
Trachea3.55
TrigeminalGanglion4.35
Uterus3.4
UterusCorpus3.85
WholeBlood4.9
Wholebrain3.65
colon4.15
pineal_day5.02
pineal_night4.96
retina5.075
small_intestine4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8880_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.38 ± 1.08
Basal Forebrain1.82 ± 0.32
Basal Part of Pons1.42 ± 0.47
Cerebellar Cortex1.67 ± 0.6
Cerebellar Nuclei2.18 ± 0.91
Claustrum2.66 ± 1.05
Epithalamus1.43 ± 0.72
Frontal Lobe1.61 ± 0.71
Globus Pallidus2.17 ± 0.35
Hypothalamus1.82 ± 0.69
Insula1.55 ± 0.49
Limbic Lobe1.82 ± 0.74
Mesencephalon1.92 ± 0.77
Myelencephalon1.88 ± 0.69
Occipital Lobe1.89 ± 0.77
Parietal Lobe1.92 ± 0.82
Pontine Tegmentum1.93 ± 0.75
Striatum2.05 ± 0.92
Subthalamus1.93 ± 0.7
Temporal Lobe1.75 ± 0.73
Thalamus1.8 ± 0.71
White Matter2.22 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lmo6CBCerebellum16.46
23.89
Lmo6CTXCerebral cortex22.51
16.48
Lmo6HIPHippocampal region9.86
9
Lmo6HPFHippocampal formation16.84
13.9
Lmo6HYHypothalamus3.84
3.08
Lmo6LSXLateral septal complex1.55
1.54
Lmo6MBMidbrain10.18
10.07
Lmo6MYMedulla13.3
15.01
Lmo6OLFOlfactory bulb15.94
12.42
Lmo6PPons10.75
12.81
Lmo6PALPallidum4.41
3.6
Lmo6RHPRetrohippocampal region28.98
20.96
Lmo6sAMYStriatum-like amygdalar nuclei8.73
5.6
Lmo6STRStriatum9.42
6.78
Lmo6STRdStriatum dorsal region12.63
9.37
Lmo6STRvStriatum ventral region6.55
4.15
Lmo6THThalamus3.52
3.1
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PRIC3_HUMAN_436 9 436 444 HSMPELGLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018