AutismKB 2.0

Annotation Detail for PTPLAD2


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Basic Information Top
Gene Symbol:PTPLAD2 ( DKFZp686F01145,DKFZp686G24132,HACD4 )
Gene Full Name: protein tyrosine phosphatase-like A domain containing 2
Band: 9p21.3
Quick LinksEntrez ID:401494; OMIM: NA; Uniprot ID:HACD4_HUMAN; ENSEMBL ID: ENSG00000188921; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal34 / 336030710
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow1 / 4880120
brain1 / 11009890 
cervix0 / 481710 
connective tissue6 / 14925540
ear1 / 1621261
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney1 / 2117774
larynx1 / 2414541
liver3 / 20774314
lung0 / 3369740 
lymph0 / 442700 
lymph node10 / 91610109
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis0 / 3304420 
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5138_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.37 ± 0.87
Basal Forebrain2.8 ± 0.42
Basal Part of Pons3.04 ± 0.92
Cerebellar Cortex2.47 ± 0.5
Cerebellar Nuclei3.46 ± 0.77
Claustrum3.17 ± 0.66
Epithalamus4.52 ± 0.78
Frontal Lobe3.09 ± 0.78
Globus Pallidus3.84 ± 0.57
Hypothalamus3.26 ± 0.86
Insula2.98 ± 0.58
Limbic Lobe2.97 ± 0.68
Mesencephalon3.27 ± 0.59
Myelencephalon3.15 ± 0.72
Occipital Lobe2.65 ± 0.63
Parietal Lobe2.82 ± 0.78
Pontine Tegmentum3.07 ± 0.68
Striatum4 ± 0.54
Subthalamus3.04 ± 0.72
Temporal Lobe3.24 ± 0.65
Thalamus2.92 ± 0.6
White Matter3.17 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ptplad2CBCerebellum0
0
Ptplad2CTXCerebral cortex0
0
Ptplad2HIPHippocampal region0
0
Ptplad2HPFHippocampal formation0
0
Ptplad2HYHypothalamus0
0
Ptplad2LSXLateral septal complex0
0
Ptplad2MBMidbrain0
0
Ptplad2MYMedulla0
0
Ptplad2OLFOlfactory bulb0
0
Ptplad2PPons0
0
Ptplad2PALPallidum0
0
Ptplad2RHPRetrohippocampal region0
0
Ptplad2sAMYStriatum-like amygdalar nuclei0
0
Ptplad2STRStriatum0
0
Ptplad2STRdStriatum dorsal region0
0
Ptplad2STRvStriatum ventral region0
0
Ptplad2THThalamus0
0
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018