AutismKB 2.0

Annotation Detail for LRP1


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Basic Information Top
Gene Symbol:LRP1 ( A2MR,APOER,APR,CD91,FLJ16451,IGFBP3R,LRP,MGC88725,TGFBR5 )
Gene Full Name: low density lipoprotein receptor-related protein 1
Band: 12q13.3
Quick LinksEntrez ID:4035; OMIM: 107770; Uniprot ID:LRP1_HUMAN; ENSEMBL ID: ENSG00000123384; HGNC ID: 6692
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body32 / 70761452
blastocyst8 / 62319128
fetus70 / 564012124
neonate1 / 3109732
infant1 / 2362042
juvenile6 / 55556107
adult389 / 1939121200
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma38 / 82823458
colorectal tumor16 / 114246140
esophageal tumor0 / 172900 
gastrointestinal tumor17 / 119369142
germ cell tumor31 / 263845117
glioma41 / 106883383
head and neck tumor31 / 136302227
kidney tumor13 / 68959188
leukemia3 / 9584231
liver tumor5 / 9635951
lung tumor9 / 10312787
lymphoma0 / 717550 
non-neoplasia24 / 97250246
normal496 / 3360307147
ovarian tumor11 / 76682143
pancreatic tumor32 / 104616305
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer13 / 102680126
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor34 / 125191271
uterine tumor11 / 90257121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue7 / 13106534
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone33 / 71655460
bone marrow0 / 488010 
brain217 / 1100989197
cervix1 / 4817120
connective tissue46 / 149255308
ear0 / 162120 
embryonic tissue48 / 215722222
esophagus0 / 202090 
eye36 / 211054170
heart12 / 89626133
intestine34 / 234472145
kidney18 / 21177784
larynx6 / 24145248
liver9 / 20774343
lung49 / 336974145
lymph0 / 442700 
lymph node0 / 916100 
mammary gland29 / 153271189
mouth18 / 67052268
muscle42 / 107715389
nerve9 / 15768570
ovary23 / 102051225
pancreas38 / 214812176
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland2 / 16585120
placenta52 / 280825185
prostate30 / 189345158
salivary gland1 / 2015549
skin18 / 21057485
spleen6 / 53952111
stomach14 / 96619144
testis24 / 33044272
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus35 / 232878150
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200785_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts53.8
Adipocyte906.05
AdrenalCortex97.7
Adrenalgland78.25
Amygdala138.2
Appendix89.35
AtrioventricularNode175.65
BDCA4+_DentriticCells67.45
Bonemarrow73.15
BronchialEpithelialCells50.35
CD105+_Endothelial128
CD14+_Monocytes454.15
CD19+_BCells(neg._sel.)57.45
CD33+_Myeloid471.2
CD34+47.6
CD4+_Tcells80.55
CD56+_NKCells42.15
CD71+_EarlyErythroid68.7
CD8+_Tcells28.15
CardiacMyocytes158.7
Caudatenucleus89.45
Cerebellum78.1
CerebellumPeduncles147.85
CiliaryGanglion122.45
CingulateCortex120.75
Colorectaladenocarcinoma54.2
DorsalRootGanglion154.55
FetalThyroid157.7
Fetalbrain80.95
Fetalliver128.6
Fetallung96.7
GlobusPallidus67.4
Heart162.2
Hypothalamus88.9
Kidney57.2
Leukemia_chronicMyelogenousK-56260.55
Leukemia_promyelocytic-HL-6037.25
Leukemialymphoblastic(MOLT-4)54.8
Liver159.95
Lung186.35
Lymphnode61.3
Lymphoma_burkitts(Daudi)79.95
Lymphoma_burkitts(Raji)103.15
MedullaOblongata85.7
OccipitalLobe105.7
OlfactoryBulb251.5
Ovary191.55
Pancreas67.1
PancreaticIslet121.75
ParietalLobe82.75
Pituitary86.6
Placenta176.8
Pons87
PrefrontalCortex138.6
Prostate78.45
Salivarygland59.75
SkeletalMuscle103.75
Skin136.2
SmoothMuscle361.5
Spinalcord94.85
SubthalamicNucleus86.4
SuperiorCervicalGanglion168
TemporalLobe82.9
Testis80.25
TestisGermCell64.75
TestisIntersitial61.65
TestisLeydigCell73.75
TestisSeminiferousTubule63.9
Thalamus85.15
Thymus39.8
Thyroid154.4
Tongue89.35
Tonsil70.7
Trachea78.05
TrigeminalGanglion230.1
Uterus111.15
UterusCorpus168.05
WholeBlood57.95
Wholebrain51.55
colon125.7
pineal_day223.44
pineal_night238.08
retina485.925
small_intestine122.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3747_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.38 ± 0.47
Basal Forebrain7.22 ± 0.28
Basal Part of Pons6.78 ± 0.28
Cerebellar Cortex6.96 ± 0.47
Cerebellar Nuclei7.24 ± 0.41
Claustrum7.56 ± 0.64
Epithalamus6.93 ± 0.37
Frontal Lobe6.93 ± 0.42
Globus Pallidus7.96 ± 0.31
Hypothalamus6.84 ± 0.42
Insula6.91 ± 0.33
Limbic Lobe7.21 ± 0.58
Mesencephalon7.21 ± 0.48
Myelencephalon7.19 ± 0.54
Occipital Lobe7.4 ± 0.49
Parietal Lobe7.15 ± 0.48
Pontine Tegmentum7.21 ± 0.51
Striatum7.5 ± 0.55
Subthalamus7.14 ± 0.35
Temporal Lobe6.97 ± 0.49
Thalamus7.22 ± 0.38
White Matter7.04 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrp1CBCerebellum51.07
73.94
Lrp1CTXCerebral cortex100
100
Lrp1HIPHippocampal region95.29
100
Lrp1HPFHippocampal formation99.55
100
Lrp1HYHypothalamus59.48
51.69
Lrp1LSXLateral septal complex60.86
53.29
Lrp1MBMidbrain72.83
71.64
Lrp1MYMedulla54.94
56.83
Lrp1OLFOlfactory bulb70.17
63.21
Lrp1PPons54.91
57.37
Lrp1PALPallidum55.94
52.59
Lrp1RHPRetrohippocampal region100
100
Lrp1sAMYStriatum-like amygdalar nuclei74.46
65.37
Lrp1STRStriatum74.26
61.38
Lrp1STRdStriatum dorsal region75.21
62.26
Lrp1STRvStriatum ventral region77.39
59.83
Lrp1THThalamus61.47
58.11
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LRP1_HUMAN_1262 14 1262 1275 SLDPFKPFIIFSNR PRIDE
LRP1_HUMAN_1413 11 1413 1423 IEAASMSGAGR PRIDE
LRP1_HUMAN_1463 11 1463 1473 YDGSGHMEVLR PRIDE
LRP1_HUMAN_1788 20 1788 1807 ATALAIMGDKLWWADQVSEK PRIDE
LRP1_HUMAN_1999 12 1999 2010 YVVISQGLDKPR PRIDE
LRP1_HUMAN_2078 9 2078 2086 IDLETGENR PRIDE
LRP1_HUMAN_2195 11 2195 2205 EYAGYLLYSER PRIDE
LRP1_HUMAN_2254 20 2254 2273 IFFSDIHFGNIQQINDDGSR PRIDE
LRP1_HUMAN_2274 18 2274 2291 RITIVENVGSVEGLAYHR PRIDE
LRP1_HUMAN_2275 17 2275 2291 ITIVENVGSVEGLAYHR PRIDE
LRP1_HUMAN_2323 13 2323 2335 ETVITMSGDDHPR PRIDE
LRP1_HUMAN_2360 14 2360 2373 AALSGANVLTLIEK PRIDE
LRP1_HUMAN_2509 9 2509 2517 ILQDDLTCR PRIDE
LRP1_HUMAN_3022 14 3022 3035 AVTDEEPFLIFANR PRIDE
LRP1_HUMAN_336 11 336 346 VFFTDYGQIPK PRIDE
LRP1_HUMAN_3993 20 3993 4012 KTLISGMIDEPHAIVVDPLR PRIDE
LRP1_HUMAN_3994 19 3994 4012 TLISGMIDEPHAIVVDPLR PRIDE
LRP1_HUMAN_4026 11 4026 4036 IETAAMDGTLR PRIDE
LRP1_HUMAN_547 16 547 562 VPDEHMIPIENLMNPR PRIDE
LRP1_HUMAN_793 13 793 805 MYDAQQQQVGTNK PRIDE
PAp00000890 22 47 68 CDGERDCPDGSDEAPEICPQSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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