AutismKB 2.0

Annotation Detail for LRP4


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Basic Information Top
Gene Symbol:LRP4 ( CLSS,KIAA0816,LRP-4,LRP10,MEGF7 )
Gene Full Name: low density lipoprotein receptor-related protein 4
Band: 11p11.2
Quick LinksEntrez ID:4038; OMIM: 604270; Uniprot ID:LRP4_HUMAN; ENSEMBL ID: ENSG00000134569; HGNC ID: 6696
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult84 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor30 / 114246262
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor2 / 2638457
glioma12 / 106883112
head and neck tumor15 / 136302110
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal94 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow0 / 488010 
brain53 / 110098948
cervix1 / 4817120
connective tissue2 / 14925513
ear1 / 1621261
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye3 / 21105414
heart5 / 8962655
intestine36 / 234472153
kidney2 / 2117779
larynx1 / 2414541
liver0 / 2077430 
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle4 / 10771537
nerve2 / 15768126
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin5 / 21057423
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus1 / 8113112
thyroid12 / 47473252
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212850_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte5.45
AdrenalCortex6.35
Adrenalgland4.95
Amygdala61.35
Appendix6.25
AtrioventricularNode4.75
BDCA4+_DentriticCells5.6
Bonemarrow5.8
BronchialEpithelialCells5.4
CD105+_Endothelial5.5
CD14+_Monocytes5.9
CD19+_BCells(neg._sel.)5.75
CD33+_Myeloid6.95
CD34+6.75
CD4+_Tcells5.85
CD56+_NKCells6.25
CD71+_EarlyErythroid5.25
CD8+_Tcells5.15
CardiacMyocytes7.95
Caudatenucleus48.85
Cerebellum9.6
CerebellumPeduncles6.6
CiliaryGanglion4.35
CingulateCortex45.8
Colorectaladenocarcinoma5.6
DorsalRootGanglion4.7
FetalThyroid5.55
Fetalbrain14.7
Fetalliver5
Fetallung6.9
GlobusPallidus5.2
Heart7.95
Hypothalamus39.05
Kidney4.85
Leukemia_chronicMyelogenousK-5625
Leukemia_promyelocytic-HL-604.9
Leukemialymphoblastic(MOLT-4)4.4
Liver8.25
Lung6.5
Lymphnode4.75
Lymphoma_burkitts(Daudi)7.2
Lymphoma_burkitts(Raji)8.1
MedullaOblongata22.2
OccipitalLobe23
OlfactoryBulb21.6
Ovary3.9
Pancreas24.85
PancreaticIslet6
ParietalLobe9.95
Pituitary7.85
Placenta5.6
Pons9.6
PrefrontalCortex77.3
Prostate6.65
Salivarygland4.6
SkeletalMuscle7.1
Skin5.45
SmoothMuscle6.3
Spinalcord24.05
SubthalamicNucleus7
SuperiorCervicalGanglion7.15
TemporalLobe7.7
Testis4.9
TestisGermCell4.6
TestisIntersitial4.8
TestisLeydigCell5.65
TestisSeminiferousTubule4.8
Thalamus25.35
Thymus4.3
Thyroid6.9
Tongue5.8
Tonsil5.55
Trachea4.7
TrigeminalGanglion6
Uterus4.55
UterusCorpus12.25
WholeBlood5.95
Wholebrain34.1
colon5.7
pineal_day7.22
pineal_night6.78
retina12.9
small_intestine5.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9952_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.69 ± 0.55
Basal Forebrain5.96 ± 0.4
Basal Part of Pons5.02 ± 0.46
Cerebellar Cortex5.02 ± 0.51
Cerebellar Nuclei5.42 ± 0.38
Claustrum6.13 ± 0.68
Epithalamus5.07 ± 0.72
Frontal Lobe5.39 ± 0.6
Globus Pallidus6.59 ± 0.37
Hypothalamus5.28 ± 0.45
Insula5.43 ± 0.51
Limbic Lobe5.46 ± 0.69
Mesencephalon5.67 ± 0.71
Myelencephalon5.73 ± 0.74
Occipital Lobe5.88 ± 0.78
Parietal Lobe5.54 ± 0.56
Pontine Tegmentum5.73 ± 0.45
Striatum6.4 ± 0.66
Subthalamus4.72 ± 0.31
Temporal Lobe5.36 ± 0.5
Thalamus6.1 ± 0.51
White Matter6.46 ± 0.54
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrp4CBCerebellum8.64
9.88
Lrp4CTXCerebral cortex5.44
4.13
Lrp4HIPHippocampal region6.61
7.09
Lrp4HPFHippocampal formation5.9
5.61
Lrp4HYHypothalamus0.88
0.68
Lrp4LSXLateral septal complex2.61
2.26
Lrp4MBMidbrain1.74
1.86
Lrp4MYMedulla11.29
12.55
Lrp4OLFOlfactory bulb11.66
10.08
Lrp4PPons1.97
2.25
Lrp4PALPallidum0.72
0.62
Lrp4RHPRetrohippocampal region5.28
4.1
Lrp4sAMYStriatum-like amygdalar nuclei1.05
0.75
Lrp4STRStriatum2.2
2.54
Lrp4STRdStriatum dorsal region2.48
3.33
Lrp4STRvStriatum ventral region1.3
0.87
Lrp4THThalamus2.18
1.9
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018