AutismKB 2.0

Annotation Detail for LRP5


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Basic Information Top
Gene Symbol:LRP5 ( BMND1,EVR1,EVR4,HBM,LR3,LRP7,OPPG,OPS,OPTA1,VBCH2 )
Gene Full Name: low density lipoprotein receptor-related protein 5
Band: 11q13.2
Quick LinksEntrez ID:4041; OMIM: 603506; Uniprot ID:LRP5_HUMAN; ENSEMBL ID: ENSG00000162337; HGNC ID: 6697
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor22 / 114246192
esophageal tumor0 / 172900 
gastrointestinal tumor16 / 119369134
germ cell tumor7 / 26384526
glioma8 / 10688374
head and neck tumor16 / 136302117
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor8 / 10312777
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal71 / 336030721
ovarian tumor7 / 7668291
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer9 / 10268087
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain13 / 110098911
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye8 / 21105437
heart0 / 896260 
intestine40 / 234472170
kidney6 / 21177728
larynx17 / 24145704
liver2 / 2077439
lung22 / 33697465
lymph0 / 442700 
lymph node3 / 9161032
mammary gland13 / 15327184
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary8 / 10205178
pancreas14 / 21481265
parathyroid3 / 20539146
pharynx1 / 4132824
pituitary gland1 / 1658560
placenta10 / 28082535
prostate10 / 18934552
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach9 / 9661993
testis1 / 3304423
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209468_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.1
Adipocyte5.25
AdrenalCortex4.35
Adrenalgland3.55
Amygdala4.4
Appendix4.2
AtrioventricularNode3.45
BDCA4+_DentriticCells4.45
Bonemarrow4.2
BronchialEpithelialCells4.1
CD105+_Endothelial4.15
CD14+_Monocytes4.4
CD19+_BCells(neg._sel.)4.3
CD33+_Myeloid5.2
CD34+5.3
CD4+_Tcells4.45
CD56+_NKCells4.9
CD71+_EarlyErythroid3.9
CD8+_Tcells4
CardiacMyocytes5.6
Caudatenucleus3.7
Cerebellum3.35
CerebellumPeduncles4.75
CiliaryGanglion3
CingulateCortex4.3
Colorectaladenocarcinoma14.8
DorsalRootGanglion3.15
FetalThyroid6.6
Fetalbrain4.05
Fetalliver8.05
Fetallung4.65
GlobusPallidus3.05
Heart5.5
Hypothalamus4.45
Kidney3.6
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-603.65
Leukemialymphoblastic(MOLT-4)3.75
Liver62.05
Lung92.2
Lymphnode3.55
Lymphoma_burkitts(Daudi)5.35
Lymphoma_burkitts(Raji)5.9
MedullaOblongata4.05
OccipitalLobe4.05
OlfactoryBulb3.5
Ovary2.75
Pancreas3.3
PancreaticIslet4.45
ParietalLobe4.4
Pituitary4.85
Placenta5.4
Pons3.9
PrefrontalCortex5.15
Prostate17.55
Salivarygland3.35
SkeletalMuscle4.95
Skin3.3
SmoothMuscle4.7
Spinalcord4.4
SubthalamicNucleus3.8
SuperiorCervicalGanglion4.65
TemporalLobe3.75
Testis3.55
TestisGermCell3.5
TestisIntersitial3.45
TestisLeydigCell4.1
TestisSeminiferousTubule3.55
Thalamus4.2
Thymus3.35
Thyroid50.85
Tongue4.1
Tonsil4
Trachea4.6
TrigeminalGanglion4.1
Uterus4.5
UterusCorpus3.7
WholeBlood4.45
Wholebrain3.45
colon4.2
pineal_day5.1
pineal_night5.04
retina5.425
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15533_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.89 ± 0.89
Basal Forebrain2.66 ± 0.5
Basal Part of Pons2.19 ± 0.39
Cerebellar Cortex2.26 ± 0.53
Cerebellar Nuclei2.68 ± 0.77
Claustrum2.91 ± 0.61
Epithalamus2.81 ± 0.74
Frontal Lobe2.69 ± 0.71
Globus Pallidus3.25 ± 0.71
Hypothalamus2.48 ± 0.44
Insula2.5 ± 0.69
Limbic Lobe2.46 ± 0.7
Mesencephalon2.85 ± 1.01
Myelencephalon2.69 ± 0.72
Occipital Lobe3 ± 0.75
Parietal Lobe2.59 ± 0.73
Pontine Tegmentum2.71 ± 0.42
Striatum3.29 ± 0.66
Subthalamus2.56 ± 0.72
Temporal Lobe2.49 ± 0.66
Thalamus2.81 ± 0.63
White Matter3.36 ± 0.67
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrp5CBCerebellum15.92
21.5
Lrp5CTXCerebral cortex1.63
1.18
Lrp5HIPHippocampal region2.03
1.53
Lrp5HPFHippocampal formation3.05
2.23
Lrp5HYHypothalamus0.81
0.89
Lrp5LSXLateral septal complex4.83
3.71
Lrp5MBMidbrain2.37
3.99
Lrp5MYMedulla4.74
4.12
Lrp5OLFOlfactory bulb6.77
4.17
Lrp5PPons2.99
4.56
Lrp5PALPallidum0.67
0.51
Lrp5RHPRetrohippocampal region4.32
2.86
Lrp5sAMYStriatum-like amygdalar nuclei0.88
0.55
Lrp5STRStriatum3.03
2.29
Lrp5STRdStriatum dorsal region2.52
1.95
Lrp5STRvStriatum ventral region3.47
2.33
Lrp5THThalamus2.62
1.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LRP5_HUMAN_1085 11 1085 1095 NMQDRAAKIER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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