AutismKB 2.0

Annotation Detail for LRPAP1


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Basic Information Top
Gene Symbol:LRPAP1 ( A2MRAP,A2RAP,HBP44,MGC138272,MRAP,RAP )
Gene Full Name: low density lipoprotein receptor-related protein associated protein 1
Band: 4p16.3
Quick LinksEntrez ID:4043; OMIM: 104225; Uniprot ID:AMRP_HUMAN; ENSEMBL ID: ENSG00000163956; HGNC ID: 6701
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst4 / 6231964
fetus45 / 56401279
neonate0 / 310970 
infant2 / 2362084
juvenile4 / 5555671
adult293 / 1939121151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor5 / 34366145
chondrosarcoma23 / 82823277
colorectal tumor17 / 114246148
esophageal tumor4 / 17290231
gastrointestinal tumor17 / 119369142
germ cell tumor17 / 26384564
glioma22 / 106883205
head and neck tumor11 / 13630280
kidney tumor9 / 68959130
leukemia10 / 95842104
liver tumor12 / 96359124
lung tumor17 / 103127164
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal393 / 3360307116
ovarian tumor14 / 76682182
pancreatic tumor32 / 104616305
primitive neuroectodermal tumor of the CNS24 / 125680190
prostate cancer21 / 102680204
retinoblastoma3 / 4635664
skin tumor61 / 124949488
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland6 / 33197180
ascites3 / 4001574
bladder3 / 29757100
blood14 / 123478113
bone14 / 71655195
bone marrow3 / 4880161
brain128 / 1100989116
cervix7 / 48171145
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue26 / 215722120
esophagus4 / 20209197
eye26 / 211054123
heart8 / 8962689
intestine29 / 234472123
kidney22 / 211777103
larynx0 / 241450 
liver21 / 207743101
lung54 / 336974160
lymph1 / 4427022
lymph node1 / 9161010
mammary gland8 / 15327152
mouth1 / 6705214
muscle8 / 10771574
nerve5 / 15768317
ovary20 / 102051195
pancreas50 / 214812232
parathyroid8 / 20539389
pharynx1 / 4132824
pituitary gland6 / 16585361
placenta80 / 280825284
prostate24 / 189345126
salivary gland8 / 20155396
skin73 / 210574346
spleen11 / 53952203
stomach13 / 96619134
testis32 / 33044296
thymus3 / 8113136
thyroid5 / 47473105
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus24 / 232878103
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201186_at
Cell line Expression level Expression bar
721_B_lymphoblasts82
Adipocyte58.2
AdrenalCortex43.9
Adrenalgland79.7
Amygdala201.45
Appendix21.2
AtrioventricularNode4.2
BDCA4+_DentriticCells241.7
Bonemarrow97.9
BronchialEpithelialCells129.85
CD105+_Endothelial100.5
CD14+_Monocytes394.55
CD19+_BCells(neg._sel.)142.35
CD33+_Myeloid560.65
CD34+179
CD4+_Tcells108.25
CD56+_NKCells268.9
CD71+_EarlyErythroid56.2
CD8+_Tcells100.15
CardiacMyocytes79.4
Caudatenucleus461
Cerebellum57.45
CerebellumPeduncles81.6
CiliaryGanglion17.65
CingulateCortex54.7
Colorectaladenocarcinoma101.05
DorsalRootGanglion10.45
FetalThyroid241.1
Fetalbrain51.65
Fetalliver14.25
Fetallung86.2
GlobusPallidus68.3
Heart252.55
Hypothalamus159.95
Kidney82.85
Leukemia_chronicMyelogenousK-56214.85
Leukemia_promyelocytic-HL-6027.3
Leukemialymphoblastic(MOLT-4)45.6
Liver137.5
Lung537.1
Lymphnode71.9
Lymphoma_burkitts(Daudi)53.15
Lymphoma_burkitts(Raji)147.1
MedullaOblongata88.8
OccipitalLobe91.75
OlfactoryBulb79.6
Ovary53.1
Pancreas64.3
PancreaticIslet284
ParietalLobe71.6
Pituitary218.8
Placenta476.85
Pons97
PrefrontalCortex131.15
Prostate277.95
Salivarygland79.95
SkeletalMuscle12.5
Skin20.55
SmoothMuscle171.45
Spinalcord98.25
SubthalamicNucleus73.5
SuperiorCervicalGanglion6.55
TemporalLobe74.2
Testis196.8
TestisGermCell108.55
TestisIntersitial83.15
TestisLeydigCell98.8
TestisSeminiferousTubule57.15
Thalamus140.35
Thymus78.1
Thyroid383.15
Tongue51.5
Tonsil15.05
Trachea75.5
TrigeminalGanglion5.5
Uterus143.7
UterusCorpus35.7
WholeBlood144.95
Wholebrain249.8
colon85.55
pineal_day853.9
pineal_night1277.9
retina166.15
small_intestine64.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P29851
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.07 ± 0.26
Basal Forebrain8.99 ± 0.34
Basal Part of Pons8.58 ± 0.38
Cerebellar Cortex8.6 ± 0.1
Cerebellar Nuclei8.26 ± 0.28
Claustrum8.88 ± 0.18
Epithalamus8.92 ± 0.19
Frontal Lobe8.83 ± 0.32
Globus Pallidus8.56 ± 0.3
Hypothalamus9 ± 0.36
Insula8.85 ± 0.22
Limbic Lobe8.88 ± 0.25
Mesencephalon8.76 ± 0.43
Myelencephalon8.82 ± 0.39
Occipital Lobe8.5 ± 0.32
Parietal Lobe8.73 ± 0.3
Pontine Tegmentum8.88 ± 0.44
Striatum10.07 ± 0.48
Subthalamus8.49 ± 0.59
Temporal Lobe8.86 ± 0.29
Thalamus8.69 ± 0.31
White Matter8.15 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lrpap1CBCerebellum45.73
100
Lrpap1CTXCerebral cortex100
100
Lrpap1HIPHippocampal region100
100
Lrpap1HPFHippocampal formation100
100
Lrpap1HYHypothalamus100
100
Lrpap1LSXLateral septal complex100
100
Lrpap1MBMidbrain100
100
Lrpap1MYMedulla98.45
100
Lrpap1OLFOlfactory bulb100
100
Lrpap1PPons83.54
100
Lrpap1PALPallidum95.16
100
Lrpap1RHPRetrohippocampal region100
100
Lrpap1sAMYStriatum-like amygdalar nuclei100
100
Lrpap1STRStriatum100
100
Lrpap1STRdStriatum dorsal region100
100
Lrpap1STRvStriatum ventral region100
100
Lrpap1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
AMRP_HUMAN_132 19 132 150 QVTSNSLSGTQEDGLDDPR PRIDE
AMRP_HUMAN_240 16 240 255 VSHQGYSTEAEFEEPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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