AutismKB 2.0

Annotation Detail for LSS


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LSS ( FLJ25486,FLJ35015,FLJ39450,FLJ46393,OSC )
Gene Full Name: lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Band: 21q22.3
Quick LinksEntrez ID:4047; OMIM: 600909; Uniprot ID:ERG7_HUMAN; ENSEMBL ID: ENSG00000160285; HGNC ID: 6708
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body13 / 70761183
blastocyst8 / 62319128
fetus73 / 564012129
neonate5 / 31097160
infant3 / 23620127
juvenile6 / 55556107
adult209 / 1939121107
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor8 / 9417884
cervical tumor0 / 343660 
chondrosarcoma12 / 82823144
colorectal tumor11 / 11424696
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor58 / 263845219
glioma10 / 10688393
head and neck tumor12 / 13630288
kidney tumor7 / 68959101
leukemia8 / 9584283
liver tumor14 / 96359145
lung tumor10 / 10312796
lymphoma10 / 71755139
non-neoplasia7 / 9725071
normal410 / 3360307122
ovarian tumor5 / 7668265
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS22 / 125680175
prostate cancer24 / 102680233
retinoblastoma4 / 4635686
skin tumor8 / 12494964
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland6 / 33197180
ascites6 / 40015149
bladder2 / 2975767
blood4 / 12347832
bone4 / 7165555
bone marrow3 / 4880161
brain238 / 1100989216
cervix0 / 481710 
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue29 / 215722134
esophagus0 / 202090 
eye23 / 211054108
heart3 / 8962633
intestine19 / 23447281
kidney12 / 21177756
larynx1 / 2414541
liver21 / 207743101
lung51 / 336974151
lymph9 / 44270203
lymph node2 / 9161021
mammary gland10 / 15327165
mouth10 / 67052149
muscle14 / 107715129
nerve2 / 15768126
ovary9 / 10205188
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta23 / 28082581
prostate33 / 189345174
salivary gland2 / 2015599
skin18 / 21057485
spleen1 / 5395218
stomach3 / 9661931
testis67 / 330442202
thymus10 / 81131123
thyroid1 / 4747321
tonsil1 / 1699958
trachea9 / 52413171
umbilical cord3 / 13680219
uterus19 / 23287881
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211019_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts66.95
Adipocyte62.2
AdrenalCortex12.05
Adrenalgland9
Amygdala9.95
Appendix9
AtrioventricularNode7.3
BDCA4+_DentriticCells10.1
Bonemarrow9.8
BronchialEpithelialCells9.75
CD105+_Endothelial8.85
CD14+_Monocytes8.85
CD19+_BCells(neg._sel.)8.05
CD33+_Myeloid11.45
CD34+9.4
CD4+_Tcells10.85
CD56+_NKCells11.55
CD71+_EarlyErythroid8.3
CD8+_Tcells11.15
CardiacMyocytes11
Caudatenucleus12.7
Cerebellum10.05
CerebellumPeduncles11.3
CiliaryGanglion7.1
CingulateCortex18.15
Colorectaladenocarcinoma8
DorsalRootGanglion9.5
FetalThyroid11.15
Fetalbrain8.6
Fetalliver19.25
Fetallung8.45
GlobusPallidus7.55
Heart18.45
Hypothalamus10.8
Kidney8.9
Leukemia_chronicMyelogenousK-56210.15
Leukemia_promyelocytic-HL-6011.55
Leukemialymphoblastic(MOLT-4)13.9
Liver14.4
Lung10.6
Lymphnode9.1
Lymphoma_burkitts(Daudi)12.45
Lymphoma_burkitts(Raji)116.85
MedullaOblongata12.3
OccipitalLobe8.5
OlfactoryBulb7.45
Ovary6.8
Pancreas7.85
PancreaticIslet10.35
ParietalLobe10.2
Pituitary13.25
Placenta9.05
Pons11.05
PrefrontalCortex19
Prostate11.7
Salivarygland7.8
SkeletalMuscle13.35
Skin7.4
SmoothMuscle11.15
Spinalcord10.45
SubthalamicNucleus8.85
SuperiorCervicalGanglion12.05
TemporalLobe9.25
Testis8.4
TestisGermCell7.6
TestisIntersitial8.2
TestisLeydigCell10.1
TestisSeminiferousTubule8.45
Thalamus10.05
Thymus7.15
Thyroid12.5
Tongue8.65
Tonsil10.7
Trachea8.25
TrigeminalGanglion8.8
Uterus7.7
UterusCorpus8.65
WholeBlood8.65
Wholebrain8.05
colon9.25
pineal_day11.86
pineal_night10.66
retina11.75
small_intestine8.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P162211
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.18 ± 0.97
Basal Forebrain1.96 ± 0.31
Basal Part of Pons1.27 ± 0.39
Cerebellar Cortex1.86 ± 0.75
Cerebellar Nuclei2.12 ± 0.65
Claustrum2.67 ± 0.84
Epithalamus1.79 ± 0.6
Frontal Lobe1.75 ± 0.67
Globus Pallidus2.02 ± 0.31
Hypothalamus1.87 ± 0.73
Insula1.61 ± 0.45
Limbic Lobe1.75 ± 0.58
Mesencephalon1.88 ± 0.66
Myelencephalon1.85 ± 0.61
Occipital Lobe1.79 ± 0.58
Parietal Lobe1.75 ± 0.65
Pontine Tegmentum1.96 ± 0.65
Striatum1.91 ± 0.7
Subthalamus1.97 ± 0.65
Temporal Lobe1.61 ± 0.48
Thalamus1.78 ± 0.57
White Matter3.48 ± 1.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LssCBCerebellum0.17
0.28
LssCTXCerebral cortex0.81
0.83
LssHIPHippocampal region0.59
1.41
LssHPFHippocampal formation0.52
0.99
LssHYHypothalamus0.51
0.37
LssLSXLateral septal complex0.29
0.23
LssMBMidbrain0.65
0.93
LssMYMedulla1.94
2.03
LssOLFOlfactory bulb0.66
0.91
LssPPons1.1
1.63
LssPALPallidum1.99
3.02
LssRHPRetrohippocampal region0.36
0.38
LsssAMYStriatum-like amygdalar nuclei0.49
0.45
LssSTRStriatum0.46
0.39
LssSTRdStriatum dorsal region0.47
0.36
LssSTRvStriatum ventral region0.53
0.49
LssTHThalamus1.78
2.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004735 12 483 494 LCDAVAVLLNMR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved