AutismKB 2.0

Annotation Detail for LUM


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Basic Information Top
Gene Symbol:LUM ( LDC,SLRR2D )
Gene Full Name: lumican
Band: 12q21.33
Quick LinksEntrez ID:4060; OMIM: 600616; Uniprot ID:LUM_HUMAN; ENSEMBL ID: ENSG00000139329; HGNC ID: 6724
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body34 / 70761480
blastocyst1 / 6231916
fetus146 / 564012258
neonate27 / 31097868
infant0 / 236200 
juvenile5 / 5555689
adult495 / 1939121255
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma6 / 17475343
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma40 / 82823482
colorectal tumor18 / 114246157
esophageal tumor14 / 17290809
gastrointestinal tumor38 / 119369318
germ cell tumor31 / 263845117
glioma0 / 1068830 
head and neck tumor9 / 13630266
kidney tumor6 / 6895987
leukemia2 / 9584220
liver tumor9 / 9635993
lung tumor8 / 10312777
lymphoma9 / 71755125
non-neoplasia145 / 972501491
normal998 / 3360307296
ovarian tumor6 / 7668278
pancreatic tumor64 / 104616611
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor20 / 125191159
uterine tumor47 / 90257520
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue6 / 13106457
adrenal gland11 / 33197331
ascites0 / 400150 
bladder5 / 29757168
blood1 / 1234788
bone33 / 71655460
bone marrow4 / 4880181
brain27 / 110098924
cervix15 / 48171311
connective tissue187 / 1492551252
ear6 / 16212370
embryonic tissue113 / 215722523
esophagus16 / 20209791
eye29 / 211054137
heart91 / 896261015
intestine88 / 234472375
kidney28 / 211777132
larynx2 / 2414582
liver16 / 20774377
lung123 / 336974365
lymph0 / 442700 
lymph node3 / 9161032
mammary gland20 / 153271130
mouth10 / 67052149
muscle14 / 107715129
nerve2 / 15768126
ovary12 / 102051117
pancreas70 / 214812325
parathyroid1 / 2053948
pharynx27 / 41328653
pituitary gland1 / 1658560
placenta338 / 2808251203
prostate14 / 18934573
salivary gland1 / 2015549
skin20 / 21057494
spleen1 / 5395218
stomach51 / 96619527
testis19 / 33044257
thymus6 / 8113173
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord26 / 136801900
uterus152 / 232878652
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201744_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.2
Adipocyte861.25
AdrenalCortex150.3
Adrenalgland223
Amygdala10.2
Appendix291.35
AtrioventricularNode37.3
BDCA4+_DentriticCells8.9
Bonemarrow12.5
BronchialEpithelialCells9.95
CD105+_Endothelial12.75
CD14+_Monocytes12
CD19+_BCells(neg._sel.)10.65
CD33+_Myeloid14.05
CD34+11.9
CD4+_Tcells8.9
CD56+_NKCells11.15
CD71+_EarlyErythroid10.1
CD8+_Tcells7.8
CardiacMyocytes19.35
Caudatenucleus9.85
Cerebellum8.7
CerebellumPeduncles15.4
CiliaryGanglion26.2
CingulateCortex12.2
Colorectaladenocarcinoma10.55
DorsalRootGanglion98.55
FetalThyroid127.95
Fetalbrain9.85
Fetalliver32.75
Fetallung979.35
GlobusPallidus10
Heart21.8
Hypothalamus10.95
Kidney15
Leukemia_chronicMyelogenousK-5629.4
Leukemia_promyelocytic-HL-609.35
Leukemialymphoblastic(MOLT-4)7.3
Liver18.55
Lung105.65
Lymphnode518.6
Lymphoma_burkitts(Daudi)15.3
Lymphoma_burkitts(Raji)17.55
MedullaOblongata8.8
OccipitalLobe9.65
OlfactoryBulb362.55
Ovary753.7
Pancreas120.1
PancreaticIslet195.15
ParietalLobe13.95
Pituitary14.85
Placenta884
Pons12.65
PrefrontalCortex10.85
Prostate137.7
Salivarygland49.35
SkeletalMuscle21.8
Skin58.35
SmoothMuscle52.35
Spinalcord13.45
SubthalamicNucleus11.6
SuperiorCervicalGanglion39.7
TemporalLobe11.75
Testis10.5
TestisGermCell221.75
TestisIntersitial122.85
TestisLeydigCell52.35
TestisSeminiferousTubule12.55
Thalamus11.7
Thymus14
Thyroid552.7
Tongue256.1
Tonsil173.75
Trachea288.35
TrigeminalGanglion39.1
Uterus2286.4
UterusCorpus247.25
WholeBlood11.2
Wholebrain7.4
colon476.5
pineal_day55.76
pineal_night148.82
retina14.45
small_intestine949.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P28664
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.03 ± 0.98
Basal Forebrain1.58 ± 0.19
Basal Part of Pons1.34 ± 0.39
Cerebellar Cortex1.45 ± 0.74
Cerebellar Nuclei1.86 ± 0.7
Claustrum2.37 ± 0.76
Epithalamus1.29 ± 0.65
Frontal Lobe1.43 ± 0.6
Globus Pallidus2.17 ± 0.36
Hypothalamus1.64 ± 0.63
Insula1.5 ± 0.54
Limbic Lobe1.6 ± 0.6
Mesencephalon1.73 ± 0.66
Myelencephalon1.62 ± 0.63
Occipital Lobe1.65 ± 0.6
Parietal Lobe1.59 ± 0.63
Pontine Tegmentum1.61 ± 0.63
Striatum1.76 ± 0.49
Subthalamus1.73 ± 0.6
Temporal Lobe1.47 ± 0.56
Thalamus1.56 ± 0.55
White Matter2.2 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LumCBCerebellum2.49
5.83
LumCTXCerebral cortex6.19
5.35
LumHIPHippocampal region5.25
7.75
LumHPFHippocampal formation4.93
6.3
LumHYHypothalamus2.09
2.59
LumLSXLateral septal complex3.95
4.57
LumMBMidbrain2.32
3.8
LumMYMedulla2.95
5.65
LumOLFOlfactory bulb5.72
4.52
LumPPons2.35
3.96
LumPALPallidum4.39
4.21
LumRHPRetrohippocampal region4.21
4.07
LumsAMYStriatum-like amygdalar nuclei5.13
4.59
LumSTRStriatum3.02
2.42
LumSTRdStriatum dorsal region2.66
1.96
LumSTRvStriatum ventral region2.58
1.78
LumTHThalamus5.65
6.66
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LUM_HUMAN_138 11 138 148 SLEDLQLTHNK PRIDE
LUM_HUMAN_171 11 171 181 LKEDAVSAAFK PRIDE
LUM_HUMAN_185 14 185 198 SLEYLDLSFNQIAR PRIDE
LUM_HUMAN_199 18 199 216 LPSGLPVSLLTLYLDNNK PRIDE
LUM_HUMAN_217 10 217 226 ISNIPDEYFK PRIDE
LUM_HUMAN_228 8 228 235 FNALQYLR PRIDE
LUM_HUMAN_75 10 75 84 NNQIDHIDEK PRIDE
PAp00024058 22 85 106 AFENVTDLQWLILDHNLLENSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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