AutismKB 2.0

Annotation Detail for LYN


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Basic Information Top
Gene Symbol:LYN ( FLJ26625,JTK8 )
Gene Full Name: v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Band: 8q12.1
Quick LinksEntrez ID:4067; OMIM: 165120; Uniprot ID:LYN_HUMAN; ENSEMBL ID: ENSG00000147507,ENSG00000249529,ENSG00000250967; HGNC ID: 6735
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus32 / 56401256
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor8 / 26384530
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia17 / 95842177
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma22 / 71755306
non-neoplasia1 / 9725010
normal153 / 336030745
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites3 / 4001574
bladder1 / 2975733
blood7 / 12347856
bone3 / 7165541
bone marrow1 / 4880120
brain8 / 11009897
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye8 / 21105437
heart0 / 896260 
intestine5 / 23447221
kidney8 / 21177737
larynx1 / 2414541
liver5 / 20774324
lung29 / 33697486
lymph15 / 44270338
lymph node23 / 91610251
mammary gland6 / 15327139
mouth0 / 670520 
muscle2 / 10771518
nerve2 / 15768126
ovary2 / 10205119
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta28 / 28082599
prostate12 / 18934563
salivary gland0 / 201550 
skin3 / 21057414
spleen5 / 5395292
stomach4 / 9661941
testis2 / 3304426
thymus1 / 8113112
thyroid1 / 4747321
tonsil8 / 16999470
trachea1 / 5241319
umbilical cord0 / 136800 
uterus11 / 23287847
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210754_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts272.95
Adipocyte5.3
AdrenalCortex5.55
Adrenalgland4.55
Amygdala5.35
Appendix5.85
AtrioventricularNode4.2
BDCA4+_DentriticCells823.15
Bonemarrow96.85
BronchialEpithelialCells13.9
CD105+_Endothelial6.45
CD14+_Monocytes730.65
CD19+_BCells(neg._sel.)765.4
CD33+_Myeloid617.6
CD34+136.55
CD4+_Tcells5.25
CD56+_NKCells625.15
CD71+_EarlyErythroid4.55
CD8+_Tcells5.4
CardiacMyocytes7.05
Caudatenucleus3.95
Cerebellum6.1
CerebellumPeduncles7.4
CiliaryGanglion3.6
CingulateCortex5.1
Colorectaladenocarcinoma5.1
DorsalRootGanglion4.7
FetalThyroid7.25
Fetalbrain6
Fetalliver5.35
Fetallung25.25
GlobusPallidus3.15
Heart6.5
Hypothalamus6.5
Kidney3.8
Leukemia_chronicMyelogenousK-56219.15
Leukemia_promyelocytic-HL-6018.55
Leukemialymphoblastic(MOLT-4)3.9
Liver8.15
Lung32.85
Lymphnode21.15
Lymphoma_burkitts(Daudi)29.2
Lymphoma_burkitts(Raji)179.05
MedullaOblongata4.85
OccipitalLobe4.7
OlfactoryBulb5.45
Ovary3.6
Pancreas10.9
PancreaticIslet19.3
ParietalLobe5.25
Pituitary8.15
Placenta103.1
Pons5.45
PrefrontalCortex6.3
Prostate7
Salivarygland4.55
SkeletalMuscle7.2
Skin4.4
SmoothMuscle8.25
Spinalcord7
SubthalamicNucleus4.6
SuperiorCervicalGanglion7
TemporalLobe5.6
Testis4.25
TestisGermCell5.15
TestisIntersitial4.15
TestisLeydigCell4.95
TestisSeminiferousTubule4.4
Thalamus4.9
Thymus5.05
Thyroid7.6
Tongue4.55
Tonsil65.3
Trachea10.7
TrigeminalGanglion6.2
Uterus4.75
UterusCorpus5.5
WholeBlood496.75
Wholebrain5.65
colon5.8
pineal_day8.02
pineal_night9.14
retina7.35
small_intestine34
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P147431
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.12 ± 0.59
Basal Forebrain6.17 ± 0.81
Basal Part of Pons6.26 ± 0.63
Cerebellar Cortex6.9 ± 0.36
Cerebellar Nuclei6.6 ± 0.57
Claustrum5.22 ± 0.97
Epithalamus7.38 ± 0.49
Frontal Lobe6.32 ± 0.55
Globus Pallidus5.74 ± 0.52
Hypothalamus5.77 ± 1.12
Insula6.47 ± 0.48
Limbic Lobe6.31 ± 0.63
Mesencephalon5.98 ± 0.72
Myelencephalon6.12 ± 0.7
Occipital Lobe5.97 ± 0.59
Parietal Lobe6.06 ± 0.62
Pontine Tegmentum6.01 ± 0.72
Striatum5.65 ± 0.67
Subthalamus6.3 ± 0.28
Temporal Lobe6.21 ± 0.52
Thalamus5.73 ± 0.53
White Matter5.37 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LynCBCerebellum22.26
25.56
LynCTXCerebral cortex30.04
21.43
LynHIPHippocampal region21.99
21.28
LynHPFHippocampal formation31.91
29.07
LynHYHypothalamus12.2
10.6
LynLSXLateral septal complex2.02
1.5
LynMBMidbrain5.48
5.56
LynMYMedulla24.24
24.94
LynOLFOlfactory bulb54.95
44.67
LynPPons19.1
19.52
LynPALPallidum16.29
15.33
LynRHPRetrohippocampal region46.32
37.91
LynsAMYStriatum-like amygdalar nuclei23.45
17.28
LynSTRStriatum13.18
9.71
LynSTRdStriatum dorsal region10.2
6.95
LynSTRvStriatum ventral region22.53
17.5
LynTHThalamus8.46
6.88
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LYN_HUMAN_301 10 301 310 LVRLYAVVTR PRIDE
LYN_HUMAN_369 13 369 381 AANVLVSESLMCK PRIDE
LYN_HUMAN_390 10 390 399 VIEDNEYTAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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