AutismKB 2.0

Annotation Detail for TM4SF1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:TM4SF1 ( H-L6,L6,M3S1,TAAL6 )
Gene Full Name: transmembrane 4 L six family member 1
Band: 3q25.1
Quick LinksEntrez ID:4071; OMIM: 191155; Uniprot ID:T4S1_HUMAN; ENSEMBL ID: ENSG00000169908; HGNC ID: 11853
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus57 / 564012101
neonate5 / 31097160
infant1 / 2362042
juvenile3 / 5555653
adult479 / 1939121247
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor38 / 343661105
chondrosarcoma38 / 82823458
colorectal tumor21 / 114246183
esophageal tumor2 / 17290115
gastrointestinal tumor68 / 119369569
germ cell tumor7 / 26384526
glioma26 / 106883243
head and neck tumor27 / 136302198
kidney tumor9 / 68959130
leukemia13 / 95842135
liver tumor49 / 96359508
lung tumor31 / 103127300
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal561 / 3360307166
ovarian tumor27 / 76682352
pancreatic tumor77 / 104616736
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer46 / 102680447
retinoblastoma0 / 463560 
skin tumor38 / 124949304
soft tissue/muscle tissue tumor26 / 125191207
uterine tumor17 / 90257188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue18 / 131061373
adrenal gland2 / 3319760
ascites32 / 40015799
bladder5 / 29757168
blood0 / 1234780 
bone17 / 71655237
bone marrow14 / 48801286
brain73 / 110098966
cervix40 / 48171830
connective tissue19 / 149255127
ear5 / 16212308
embryonic tissue7 / 21572232
esophagus2 / 2020998
eye18 / 21105485
heart26 / 89626290
intestine40 / 234472170
kidney36 / 211777169
larynx10 / 24145414
liver78 / 207743375
lung127 / 336974376
lymph0 / 442700 
lymph node2 / 9161021
mammary gland19 / 153271123
mouth9 / 67052134
muscle18 / 107715167
nerve2 / 15768126
ovary53 / 102051519
pancreas122 / 214812567
parathyroid4 / 20539194
pharynx13 / 41328314
pituitary gland1 / 1658560
placenta67 / 280825238
prostate67 / 189345353
salivary gland2 / 2015599
skin41 / 210574194
spleen5 / 5395292
stomach48 / 96619496
testis12 / 33044236
thymus0 / 811310 
thyroid6 / 47473126
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord5 / 13680365
uterus53 / 232878227
vascular46 / 51780888
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209386_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.6
Adipocyte8.6
AdrenalCortex42.25
Adrenalgland78.85
Amygdala22.6
Appendix147.4
AtrioventricularNode21.3
BDCA4+_DentriticCells7.05
Bonemarrow10.3
BronchialEpithelialCells198.45
CD105+_Endothelial10.6
CD14+_Monocytes7.9
CD19+_BCells(neg._sel.)7.8
CD33+_Myeloid8.05
CD34+10.2
CD4+_Tcells7.45
CD56+_NKCells7.15
CD71+_EarlyErythroid6.15
CD8+_Tcells6.05
CardiacMyocytes475.1
Caudatenucleus7.7
Cerebellum7.3
CerebellumPeduncles13.45
CiliaryGanglion85.15
CingulateCortex10.95
Colorectaladenocarcinoma50.3
DorsalRootGanglion44.45
FetalThyroid60.35
Fetalbrain7.5
Fetalliver14.9
Fetallung408.2
GlobusPallidus9.2
Heart19.5
Hypothalamus53.8
Kidney31.85
Leukemia_chronicMyelogenousK-5627.3
Leukemia_promyelocytic-HL-607.55
Leukemialymphoblastic(MOLT-4)4.85
Liver23.1
Lung234.2
Lymphnode84.75
Lymphoma_burkitts(Daudi)9.05
Lymphoma_burkitts(Raji)14.45
MedullaOblongata9.05
OccipitalLobe10.15
OlfactoryBulb200.9
Ovary102.9
Pancreas69.85
PancreaticIslet239.15
ParietalLobe8.2
Pituitary28.35
Placenta216.25
Pons33.3
PrefrontalCortex44
Prostate100.8
Salivarygland74.85
SkeletalMuscle22.5
Skin97.35
SmoothMuscle230.4
Spinalcord53.75
SubthalamicNucleus10.25
SuperiorCervicalGanglion36.65
TemporalLobe8.85
Testis18.65
TestisGermCell74.6
TestisIntersitial40.35
TestisLeydigCell31.85
TestisSeminiferousTubule32.15
Thalamus12.65
Thymus25.2
Thyroid153.8
Tongue182.3
Tonsil75.4
Trachea124.3
TrigeminalGanglion73.65
Uterus209
UterusCorpus34.05
WholeBlood8.5
Wholebrain7.05
colon66.45
pineal_day73.08
pineal_night106.86
retina155
small_intestine282.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P231617
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.34 ± 0.83
Basal Forebrain3.12 ± 0.64
Basal Part of Pons3.11 ± 0.64
Cerebellar Cortex3.09 ± 0.91
Cerebellar Nuclei3.65 ± 0.7
Claustrum3.34 ± 0.72
Epithalamus3.71 ± 0.99
Frontal Lobe3.42 ± 0.81
Globus Pallidus4.56 ± 0.47
Hypothalamus3.07 ± 0.49
Insula3.5 ± 0.53
Limbic Lobe3.14 ± 0.84
Mesencephalon3.49 ± 0.77
Myelencephalon3.43 ± 0.81
Occipital Lobe3.7 ± 0.47
Parietal Lobe3.11 ± 0.78
Pontine Tegmentum3.55 ± 0.82
Striatum4.08 ± 0.69
Subthalamus3.69 ± 0.46
Temporal Lobe3.24 ± 0.8
Thalamus3.59 ± 0.71
White Matter3.63 ± 1.38
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tm4sf1CBCerebellum11.37
15.7
Tm4sf1CTXCerebral cortex12.21
9.88
Tm4sf1HIPHippocampal region15.08
19.28
Tm4sf1HPFHippocampal formation13.03
14.32
Tm4sf1HYHypothalamus5.16
5.2
Tm4sf1LSXLateral septal complex7.96
12.49
Tm4sf1MBMidbrain11.98
13.43
Tm4sf1MYMedulla13.07
15.36
Tm4sf1OLFOlfactory bulb12.89
9.89
Tm4sf1PPons9.83
11.04
Tm4sf1PALPallidum7.53
7.93
Tm4sf1RHPRetrohippocampal region9.71
7.83
Tm4sf1sAMYStriatum-like amygdalar nuclei8.11
6.66
Tm4sf1STRStriatum7.35
6.67
Tm4sf1STRdStriatum dorsal region6.46
5.51
Tm4sf1STRvStriatum ventral region7.41
5.44
Tm4sf1THThalamus10.84
12.65
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved