Annotation Detail for ARSA
Basic Information Top
| Gene Symbol: | ARSA ( MLD ) |
|---|---|
| Gene Full Name: | arylsulfatase A |
| Band: | 22q13.33 |
| Quick Links | Entrez ID:410; OMIM: 607574; Uniprot ID:ARSA_HUMAN; ENSEMBL ID: ENSG00000100299; HGNC ID: 713 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.88251
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 27 / 564012 | 47 | |
| neonate | 1 / 31097 | 32 | |
| infant | 1 / 23620 | 42 | |
| juvenile | 6 / 55556 | 107 |  |
| adult | 144 / 1939121 | 74 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 13 / 94178 | 138 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 7 / 82823 | 84 | |
| colorectal tumor | 1 / 114246 | 8 |  |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 4 / 119369 | 33 | |
| germ cell tumor | 2 / 263845 | 7 | |
| glioma | 5 / 106883 | 46 | |
| head and neck tumor | 3 / 136302 | 22 | |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 4 / 95842 | 41 | |
| liver tumor | 3 / 96359 | 31 | |
| lung tumor | 3 / 103127 | 29 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 14 / 97250 | 143 | |
| normal | 247 / 3360307 | 73 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 2 / 102680 | 19 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 4 / 124949 | 32 | |
| soft tissue/muscle tissue tumor | 1 / 125191 | 7 | |
| uterine tumor | 5 / 90257 | 55 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 4 / 13106 | 305 |  |
| adrenal gland | 3 / 33197 | 90 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 5 / 29757 | 168 | |
| blood | 9 / 123478 | 72 | |
| bone | 8 / 71655 | 111 | |
| bone marrow | 4 / 48801 | 81 | |
| brain | 70 / 1100989 | 63 | |
| cervix | 5 / 48171 | 103 | |
| connective tissue | 9 / 149255 | 60 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 2 / 20209 | 98 | |
| eye | 5 / 211054 | 23 | |
| heart | 1 / 89626 | 11 | |
| intestine | 11 / 234472 | 46 | |
| kidney | 14 / 211777 | 66 | |
| larynx | 0 / 24145 | 0 | |
| liver | 22 / 207743 | 105 | |
| lung | 18 / 336974 | 53 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 16 / 153271 | 104 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 5 / 107715 | 46 | |
| nerve | 3 / 15768 | 190 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 8 / 214812 | 37 | |
| parathyroid | 3 / 20539 | 146 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 36 / 280825 | 128 | |
| prostate | 7 / 189345 | 36 | |
| salivary gland | 2 / 20155 | 99 | |
| skin | 6 / 210574 | 28 | |
| spleen | 8 / 53952 | 148 | |
| stomach | 9 / 96619 | 93 | |
| testis | 22 / 330442 | 66 | |
| thymus | 15 / 81131 | 184 | |
| thyroid | 3 / 47473 | 63 | |
| tonsil | 3 / 16999 | 176 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 1 / 13680 | 73 | |
| uterus | 6 / 232878 | 25 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204443_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.5 | |
| Adipocyte | 4.35 | |
| AdrenalCortex | 4.55 | |
| Adrenalgland | 3.75 | |
| Amygdala | 4.6 | |
| Appendix | 5.1 | |
| AtrioventricularNode | 3.4 | |
| BDCA4+_DentriticCells | 5 | |
| Bonemarrow | 4.35 | |
| BronchialEpithelialCells | 4.4 | |
| CD105+_Endothelial | 4.35 | |
| CD14+_Monocytes | 4.7 | |
| CD19+_BCells(neg._sel.) | 4.75 | |
| CD33+_Myeloid | 5.65 | |
| CD34+ | 5.65 | |
| CD4+_Tcells | 4.85 | |
| CD56+_NKCells | 5.35 | |
| CD71+_EarlyErythroid | 4.15 | |
| CD8+_Tcells | 4.3 | |
| CardiacMyocytes | 5.35 | |
| Caudatenucleus | 4 | |
| Cerebellum | 3.6 | |
| CerebellumPeduncles | 5.05 | |
| CiliaryGanglion | 3.15 | |
| CingulateCortex | 4.5 | |
| Colorectaladenocarcinoma | 4.4 | |
| DorsalRootGanglion | 3.35 | |
| FetalThyroid | 4.65 | |
| Fetalbrain | 4.45 | |
| Fetalliver | 3.8 | |
| Fetallung | 3.7 | |
| GlobusPallidus | 3.3 | |
| Heart | 5.55 | |
| Hypothalamus | 4.8 | |
| Kidney | 3.8 | |
| Leukemia_chronicMyelogenousK-562 | 4 | |
| Leukemia_promyelocytic-HL-60 | 3.9 | |
| Leukemialymphoblastic(MOLT-4) | 3.65 | |
| Liver | 17.35 | |
| Lung | 4.9 | |
| Lymphnode | 4.75 | |
| Lymphoma_burkitts(Daudi) | 5.65 | |
| Lymphoma_burkitts(Raji) | 6.05 | |
| MedullaOblongata | 4.05 | |
| OccipitalLobe | 3.95 | |
| OlfactoryBulb | 3.45 | |
| Ovary | 2.9 | |
| Pancreas | 3.65 | |
| PancreaticIslet | 5.2 | |
| ParietalLobe | 4.55 | |
| Pituitary | 5.2 | |
| Placenta | 6.05 | |
| Pons | 4.2 | |
| PrefrontalCortex | 5.45 | |
| Prostate | 5.6 | |
| Salivarygland | 3.5 | |
| SkeletalMuscle | 4.75 | |
| Skin | 3.6 | |
| SmoothMuscle | 5.1 | |
| Spinalcord | 4.7 | |
| SubthalamicNucleus | 4.1 | |
| SuperiorCervicalGanglion | 4.9 | |
| TemporalLobe | 4 | |
| Testis | 5.7 | |
| TestisGermCell | 4.05 | |
| TestisIntersitial | 5.6 | |
| TestisLeydigCell | 5.75 | |
| TestisSeminiferousTubule | 6 | |
| Thalamus | 4.45 | |
| Thymus | 3.55 | |
| Thyroid | 5.55 | |
| Tongue | 4.35 | |
| Tonsil | 4.35 | |
| Trachea | 3.75 | |
| TrigeminalGanglion | 4.4 | |
| Uterus | 3.6 | |
| UterusCorpus | 3.9 | |
| WholeBlood | 4.95 | |
| Wholebrain | 3.75 | |
| colon | 4.05 | |
| pineal_day | 5.34 | |
| pineal_night | 5.2 | |
| retina | 4.85 | |
| small_intestine | 3.6 | |
- Probe name: A_23_P255436
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.12 ± 0.42 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.28 ± 0.42 | |
| Basal Part of Pons | 5.5 ± 0.4 | |
| Cerebellar Cortex | 5.4 ± 0.4 | |
| Cerebellar Nuclei | 5.38 ± 0.44 | |
| Claustrum | 4.89 ± 0.74 | |
| Epithalamus | 5.63 ± 0.67 | |
| Frontal Lobe | 5.42 ± 0.42 | |
| Globus Pallidus | 5.61 ± 0.26 | |
| Hypothalamus | 5.32 ± 0.58 | |
| Insula | 5.24 ± 0.37 | |
| Limbic Lobe | 5.17 ± 0.52 | |
| Mesencephalon | 5.24 ± 0.41 | |
| Myelencephalon | 5.38 ± 0.41 | |
| Occipital Lobe | 5.02 ± 0.33 | |
| Parietal Lobe | 5.16 ± 0.41 | |
| Pontine Tegmentum | 5.11 ± 0.55 | |
| Striatum | 5.19 ± 0.48 | |
| Subthalamus | 4.91 ± 0.16 | |
| Temporal Lobe | 5.32 ± 0.34 | |
| Thalamus | 5.5 ± 0.33 | |
| White Matter | 6.39 ± 0.21 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Arsa | CB | Cerebellum | 19.29 | |
| 24.11 | | |||
| Arsa | CTX | Cerebral cortex | 28.59 | |
| 21.94 | | |||
| Arsa | HIP | Hippocampal region | 16.36 | |
| 23.25 | | |||
| Arsa | HPF | Hippocampal formation | 25.21 | |
| 29.06 | | |||
| Arsa | HY | Hypothalamus | 11.78 | |
| 9.2 | | |||
| Arsa | LSX | Lateral septal complex | 1.26 | |
| 0.75 | | |||
| Arsa | MB | Midbrain | 12.21 | |
| 11 | | |||
| Arsa | MY | Medulla | 28.73 | |
| 26.27 | | |||
| Arsa | OLF | Olfactory bulb | 31.88 | |
| 27.11 | | |||
| Arsa | P | Pons | 20.09 | |
| 17.91 | | |||
| Arsa | PAL | Pallidum | 12.22 | |
| 11.63 | | |||
| Arsa | RHP | Retrohippocampal region | 41.52 | |
| 39.4 | | |||
| Arsa | sAMY | Striatum-like amygdalar nuclei | 21.52 | |
| 17.86 | | |||
| Arsa | STR | Striatum | 9.24 | |
| 7.82 | | |||
| Arsa | STRd | Striatum dorsal region | 7.42 | |
| 6.85 | | |||
| Arsa | STRv | Striatum ventral region | 9.04 | |
| 5.99 | | |||
| Arsa | TH | Thalamus | 49.11 | |
| 37.18 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| ARSA_HUMAN_463 | 16 | 463 | 478 | AQLDAAVTFGPSQVAR | PRIDE |
| ARSA_HUMAN_85 | 13 | 85 | 97 | MGMYPGVLVPSSR | PRIDE |
| ARSA_HUMAN_97 | 17 | 97 | 113 | GGLPLEEVTVAEVLAAR | PRIDE |
| PAp00024006 | 31 | 28 | 58 | ADDLGYGDLGCYGHPSSTTPNLDQLAAGGLR | Peptide Atlas |