AutismKB 2.0

Annotation Detail for MAN2A2


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Basic Information Top
Gene Symbol:MAN2A2 ( MANA2X )
Gene Full Name: mannosidase, alpha, class 2A, member 2
Band: 15q25
Quick LinksEntrez ID:4122; OMIM: 600988; Uniprot ID:MA2A2_HUMAN; ENSEMBL ID: ENSG00000196547; HGNC ID: 6825
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus52 / 56401292
neonate3 / 3109796
infant0 / 236200 
juvenile3 / 5555653
adult158 / 193912181
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor12 / 26384545
glioma10 / 10688393
head and neck tumor7 / 13630251
kidney tumor0 / 689590 
leukemia14 / 95842146
liver tumor7 / 9635972
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal316 / 336030794
ovarian tumor5 / 7668265
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor8 / 12494964
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites0 / 400150 
bladder2 / 2975767
blood19 / 123478153
bone4 / 7165555
bone marrow4 / 4880181
brain150 / 1100989136
cervix1 / 4817120
connective tissue3 / 14925520
ear3 / 16212185
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye16 / 21105475
heart1 / 8962611
intestine15 / 23447263
kidney4 / 21177718
larynx0 / 241450 
liver23 / 207743110
lung25 / 33697474
lymph0 / 442700 
lymph node5 / 9161054
mammary gland9 / 15327158
mouth2 / 6705229
muscle5 / 10771546
nerve2 / 15768126
ovary8 / 10205178
pancreas13 / 21481260
parathyroid2 / 2053997
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta18 / 28082564
prostate9 / 18934547
salivary gland0 / 201550 
skin13 / 21057461
spleen10 / 53952185
stomach4 / 9661941
testis25 / 33044275
thymus9 / 81131110
thyroid4 / 4747384
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord1 / 1368073
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219999_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.5
Adipocyte22.65
AdrenalCortex32.1
Adrenalgland22.75
Amygdala36.45
Appendix29.4
AtrioventricularNode25.5
BDCA4+_DentriticCells40.45
Bonemarrow26.85
BronchialEpithelialCells20.9
CD105+_Endothelial86.35
CD14+_Monocytes40.9
CD19+_BCells(neg._sel.)26
CD33+_Myeloid72.7
CD34+148.8
CD4+_Tcells50.65
CD56+_NKCells42.9
CD71+_EarlyErythroid79.3
CD8+_Tcells91.7
CardiacMyocytes34.1
Caudatenucleus25.3
Cerebellum26.35
CerebellumPeduncles35.95
CiliaryGanglion20.3
CingulateCortex30.85
Colorectaladenocarcinoma26.05
DorsalRootGanglion22.85
FetalThyroid25.1
Fetalbrain38.85
Fetalliver32
Fetallung22.6
GlobusPallidus30.7
Heart61.05
Hypothalamus50
Kidney21.55
Leukemia_chronicMyelogenousK-56225.6
Leukemia_promyelocytic-HL-6022.35
Leukemialymphoblastic(MOLT-4)19.4
Liver36.25
Lung28.15
Lymphnode23.25
Lymphoma_burkitts(Daudi)33.9
Lymphoma_burkitts(Raji)38.7
MedullaOblongata24.6
OccipitalLobe24.2
OlfactoryBulb31.4
Ovary18.2
Pancreas21.35
PancreaticIslet33.55
ParietalLobe29.55
Pituitary35.65
Placenta25.9
Pons26.15
PrefrontalCortex34
Prostate33.55
Salivarygland21.6
SkeletalMuscle37.5
Skin23.2
SmoothMuscle26.55
Spinalcord29.9
SubthalamicNucleus25.5
SuperiorCervicalGanglion40.5
TemporalLobe24.75
Testis19.95
TestisGermCell19.4
TestisIntersitial20.9
TestisLeydigCell26.25
TestisSeminiferousTubule21
Thalamus41.3
Thymus16.7
Thyroid35.2
Tongue30.2
Tonsil27.25
Trachea19.8
TrigeminalGanglion34.7
Uterus21.7
UterusCorpus24
WholeBlood35.7
Wholebrain22.8
colon25.85
pineal_day80.62
pineal_night47.92
retina42.6
small_intestine24.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P381838
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.99 ± 0.29
Basal Forebrain9.01 ± 0.2
Basal Part of Pons9.44 ± 0.29
Cerebellar Cortex9.08 ± 0.38
Cerebellar Nuclei9.29 ± 0.31
Claustrum8.95 ± 0.47
Epithalamus8.73 ± 0.42
Frontal Lobe9.21 ± 0.34
Globus Pallidus9.63 ± 0.35
Hypothalamus8.71 ± 0.23
Insula9.15 ± 0.35
Limbic Lobe9.19 ± 0.36
Mesencephalon9.09 ± 0.4
Myelencephalon9.14 ± 0.37
Occipital Lobe9.04 ± 0.27
Parietal Lobe9.06 ± 0.32
Pontine Tegmentum8.99 ± 0.34
Striatum9.1 ± 0.39
Subthalamus8.9 ± 0.27
Temporal Lobe9.13 ± 0.34
Thalamus9.18 ± 0.33
White Matter10.18 ± 0.2
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Man2a2CBCerebellum100
100
Man2a2CTXCerebral cortex100
100
Man2a2HIPHippocampal region100
100
Man2a2HPFHippocampal formation100
100
Man2a2HYHypothalamus47.21
38.64
Man2a2LSXLateral septal complex42.5
35.69
Man2a2MBMidbrain50.89
47.41
Man2a2MYMedulla56.55
56.4
Man2a2OLFOlfactory bulb100
100
Man2a2PPons39.14
35.84
Man2a2PALPallidum61.23
58.17
Man2a2RHPRetrohippocampal region100
100
Man2a2sAMYStriatum-like amygdalar nuclei94.9
81.87
Man2a2STRStriatum100
100
Man2a2STRdStriatum dorsal region100
100
Man2a2STRvStriatum ventral region100
100
Man2a2THThalamus78.02
74.39
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00156986 20 1059 1078 TLQAEEDTLPSAETALILHR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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