AutismKB 2.0

Annotation Detail for MAN2A1


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Basic Information Top
Gene Symbol:MAN2A1 ( GOLIM7,MANA2,MANII )
Gene Full Name: mannosidase, alpha, class 2A, member 1
Band: 5q21.3
Quick LinksEntrez ID:4124; OMIM: 154582; Uniprot ID:MA2A1_HUMAN; ENSEMBL ID: ENSG00000112893; HGNC ID: 6824
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst6 / 6231996
fetus36 / 56401263
neonate2 / 3109764
infant0 / 236200 
juvenile9 / 55556161
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor3 / 3436687
chondrosarcoma6 / 8282372
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor10 / 26384537
glioma4 / 10688337
head and neck tumor6 / 13630244
kidney tumor5 / 6895972
leukemia9 / 9584293
liver tumor18 / 96359186
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia10 / 97250102
normal169 / 336030750
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites3 / 4001574
bladder2 / 2975767
blood7 / 12347856
bone8 / 71655111
bone marrow4 / 4880181
brain55 / 110098949
cervix3 / 4817162
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye12 / 21105456
heart0 / 896260 
intestine9 / 23447238
kidney19 / 21177789
larynx1 / 2414541
liver20 / 20774396
lung8 / 33697423
lymph0 / 442700 
lymph node7 / 9161076
mammary gland8 / 15327152
mouth1 / 6705214
muscle7 / 10771564
nerve1 / 1576863
ovary1 / 1020519
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta9 / 28082532
prostate7 / 18934536
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach2 / 9661920
testis8 / 33044224
thymus6 / 8113173
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus13 / 23287855
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205105_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.2
Adipocyte30.1
AdrenalCortex9.5
Adrenalgland7.15
Amygdala10.8
Appendix7.6
AtrioventricularNode6.15
BDCA4+_DentriticCells184.25
Bonemarrow6.1
BronchialEpithelialCells155.5
CD105+_Endothelial40.25
CD14+_Monocytes36.7
CD19+_BCells(neg._sel.)87.8
CD33+_Myeloid143.35
CD34+62.25
CD4+_Tcells135.85
CD56+_NKCells92.5
CD71+_EarlyErythroid69.6
CD8+_Tcells128.5
CardiacMyocytes11.95
Caudatenucleus8.25
Cerebellum5.35
CerebellumPeduncles7.4
CiliaryGanglion5.9
CingulateCortex30.25
Colorectaladenocarcinoma7.9
DorsalRootGanglion6.85
FetalThyroid10.15
Fetalbrain6.85
Fetalliver52.15
Fetallung7.45
GlobusPallidus6.15
Heart8.25
Hypothalamus46.75
Kidney7
Leukemia_chronicMyelogenousK-5627.7
Leukemia_promyelocytic-HL-608.1
Leukemialymphoblastic(MOLT-4)7.05
Liver9.75
Lung7.1
Lymphnode10.95
Lymphoma_burkitts(Daudi)10.75
Lymphoma_burkitts(Raji)10.25
MedullaOblongata35.9
OccipitalLobe44.2
OlfactoryBulb31.8
Ovary4.9
Pancreas30.25
PancreaticIslet37.95
ParietalLobe80.4
Pituitary7.95
Placenta17.25
Pons10.75
PrefrontalCortex69.25
Prostate11.9
Salivarygland6.8
SkeletalMuscle10.05
Skin5.9
SmoothMuscle100.55
Spinalcord8.5
SubthalamicNucleus7.55
SuperiorCervicalGanglion7.85
TemporalLobe6.1
Testis5.7
TestisGermCell52.75
TestisIntersitial8.15
TestisLeydigCell9.5
TestisSeminiferousTubule12.35
Thalamus16.75
Thymus13.3
Thyroid12.55
Tongue11.6
Tonsil17.05
Trachea13.45
TrigeminalGanglion6.9
Uterus29
UterusCorpus9.15
WholeBlood12.8
Wholebrain7.25
colon66.05
pineal_day9.94
pineal_night47.76
retina60.025
small_intestine25.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P18931
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.91 ± 0.63
Basal Forebrain6.81 ± 0.49
Basal Part of Pons6.51 ± 0.45
Cerebellar Cortex5.9 ± 0.32
Cerebellar Nuclei7.31 ± 0.54
Claustrum6.18 ± 0.58
Epithalamus6.36 ± 0.72
Frontal Lobe6.72 ± 0.57
Globus Pallidus7.7 ± 0.41
Hypothalamus6.07 ± 0.42
Insula6.18 ± 0.43
Limbic Lobe6.24 ± 0.63
Mesencephalon6.64 ± 0.68
Myelencephalon6.57 ± 0.61
Occipital Lobe6.23 ± 0.58
Parietal Lobe6.55 ± 0.52
Pontine Tegmentum6.59 ± 0.55
Striatum6.81 ± 0.45
Subthalamus7.08 ± 0.52
Temporal Lobe6.29 ± 0.5
Thalamus6.74 ± 0.44
White Matter8.97 ± 0.49
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002590 29 1024 1052 FSSPTLELQGEFSPLQSSLPCDIHLVNLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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