Annotation Detail for MANBA
Basic Information Top
| Gene Symbol: | MANBA ( MANB1 ) |
|---|---|
| Gene Full Name: | mannosidase, beta A, lysosomal |
| Band: | 4q24 |
| Quick Links | Entrez ID:4126; OMIM: 609489; Uniprot ID:MANBA_HUMAN; ENSEMBL ID: ENSG00000109323; HGNC ID: 6831 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.480415
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 6 / 70761 | 84 |  |
| blastocyst | 1 / 62319 | 16 |  |
| fetus | 11 / 564012 | 19 | |
| neonate | 2 / 31097 | 64 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 71 / 1939121 | 36 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 6 / 94178 | 63 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 3 / 114246 | 26 | |
| esophageal tumor | 1 / 17290 | 57 | |
| gastrointestinal tumor | 5 / 119369 | 41 | |
| germ cell tumor | 19 / 263845 | 72 | |
| glioma | 5 / 106883 | 46 | |
| head and neck tumor | 5 / 136302 | 36 | |
| kidney tumor | 3 / 68959 | 43 | |
| leukemia | 5 / 95842 | 52 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 3 / 103127 | 29 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 4 / 97250 | 41 | |
| normal | 81 / 3360307 | 24 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 2 / 104616 | 19 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 3 / 102680 | 29 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 1 / 124949 | 8 |  |
| soft tissue/muscle tissue tumor | 1 / 125191 | 7 | |
| uterine tumor | 6 / 90257 | 66 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 2 / 29757 | 67 | |
| blood | 8 / 123478 | 64 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 3 / 48801 | 61 | |
| brain | 22 / 1100989 | 19 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 1 / 16212 | 61 | |
| embryonic tissue | 10 / 215722 | 46 | |
| esophagus | 1 / 20209 | 49 | |
| eye | 3 / 211054 | 14 | |
| heart | 1 / 89626 | 11 | |
| intestine | 4 / 234472 | 17 | |
| kidney | 7 / 211777 | 33 | |
| larynx | 0 / 24145 | 0 | |
| liver | 1 / 207743 | 4 | |
| lung | 8 / 336974 | 23 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 7 / 153271 | 45 | |
| mouth | 2 / 67052 | 29 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 7 / 214812 | 32 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 3 / 16585 | 180 | |
| placenta | 14 / 280825 | 49 | |
| prostate | 5 / 189345 | 26 | |
| salivary gland | 1 / 20155 | 49 | |
| skin | 1 / 210574 | 4 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 5 / 96619 | 51 | |
| testis | 19 / 330442 | 57 | |
| thymus | 9 / 81131 | 110 | |
| thyroid | 4 / 47473 | 84 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 5 / 52413 | 95 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 9 / 232878 | 38 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 203778_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 29.25 | |
| Adipocyte | 14.45 | |
| AdrenalCortex | 9.85 | |
| Adrenalgland | 9.55 | |
| Amygdala | 9.3 | |
| Appendix | 9.6 | |
| AtrioventricularNode | 7 | |
| BDCA4+_DentriticCells | 116.2 | |
| Bonemarrow | 9.2 | |
| BronchialEpithelialCells | 8.45 | |
| CD105+_Endothelial | 13.3 | |
| CD14+_Monocytes | 273.9 |  |
| CD19+_BCells(neg._sel.) | 105.75 | |
| CD33+_Myeloid | 388.2 | |
| CD34+ | 39.05 | |
| CD4+_Tcells | 42.15 | |
| CD56+_NKCells | 87.05 | |
| CD71+_EarlyErythroid | 9.15 | |
| CD8+_Tcells | 20.95 | |
| CardiacMyocytes | 12.15 | |
| Caudatenucleus | 7.1 | |
| Cerebellum | 5.85 | |
| CerebellumPeduncles | 10 | |
| CiliaryGanglion | 6.7 | |
| CingulateCortex | 8.5 | |
| Colorectaladenocarcinoma | 9.3 | |
| DorsalRootGanglion | 7.25 | |
| FetalThyroid | 14 | |
| Fetalbrain | 9.95 | |
| Fetalliver | 6.85 | |
| Fetallung | 13.6 | |
| GlobusPallidus | 7.05 | |
| Heart | 11.8 | |
| Hypothalamus | 13.85 | |
| Kidney | 7 | |
| Leukemia_chronicMyelogenousK-562 | 9.9 | |
| Leukemia_promyelocytic-HL-60 | 24.4 | |
| Leukemialymphoblastic(MOLT-4) | 10.9 | |
| Liver | 9.95 | |
| Lung | 12.6 | |
| Lymphnode | 10.35 | |
| Lymphoma_burkitts(Daudi) | 16.2 | |
| Lymphoma_burkitts(Raji) | 28.6 | |
| MedullaOblongata | 8.35 | |
| OccipitalLobe | 8.25 | |
| OlfactoryBulb | 7.8 | |
| Ovary | 6.25 | |
| Pancreas | 7.95 | |
| PancreaticIslet | 10.65 | |
| ParietalLobe | 10.2 | |
| Pituitary | 11.55 | |
| Placenta | 14.9 | |
| Pons | 9.3 | |
| PrefrontalCortex | 12.5 | |
| Prostate | 11.75 | |
| Salivarygland | 10.75 | |
| SkeletalMuscle | 10.45 | |
| Skin | 7.35 | |
| SmoothMuscle | 11.25 | |
| Spinalcord | 10.35 | |
| SubthalamicNucleus | 7.35 | |
| SuperiorCervicalGanglion | 10.55 | |
| TemporalLobe | 8.45 | |
| Testis | 6 | |
| TestisGermCell | 7 | |
| TestisIntersitial | 7.15 | |
| TestisLeydigCell | 8.9 | |
| TestisSeminiferousTubule | 7.25 | |
| Thalamus | 13.65 | |
| Thymus | 6.85 | |
| Thyroid | 18.05 | |
| Tongue | 9.2 | |
| Tonsil | 9.05 | |
| Trachea | 7.7 | |
| TrigeminalGanglion | 9.7 | |
| Uterus | 9.75 | |
| UterusCorpus | 8.2 | |
| WholeBlood | 16.55 | |
| Wholebrain | 6.8 | |
| colon | 9.95 | |
| pineal_day | 12.04 | |
| pineal_night | 13.02 | |
| retina | 13.375 | |
| small_intestine | 9.6 | |
- Probe name: CUST_7588_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.02 ± 0.7 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.32 ± 0.44 | |
| Basal Part of Pons | 4.38 ± 0.31 | |
| Cerebellar Cortex | 4.59 ± 0.3 | |
| Cerebellar Nuclei | 4.18 ± 0.64 | |
| Claustrum | 4.11 ± 0.74 | |
| Epithalamus | 4.39 ± 0.5 | |
| Frontal Lobe | 4.16 ± 0.63 | |
| Globus Pallidus | 4.2 ± 0.79 | |
| Hypothalamus | 4.31 ± 0.64 | |
| Insula | 4.21 ± 0.64 | |
| Limbic Lobe | 3.97 ± 0.7 | |
| Mesencephalon | 4.27 ± 0.72 | |
| Myelencephalon | 4.15 ± 0.74 | |
| Occipital Lobe | 3.98 ± 0.55 | |
| Parietal Lobe | 4.13 ± 0.66 | |
| Pontine Tegmentum | 4.14 ± 0.59 | |
| Striatum | 3.96 ± 0.91 | |
| Subthalamus | 4.44 ± 1.11 | |
| Temporal Lobe | 4.12 ± 0.72 | |
| Thalamus | 4.27 ± 0.64 | |
| White Matter | 4.96 ± 0.14 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Manba | CB | Cerebellum | 9.99 | |
| 11.85 | | |||
| Manba | CTX | Cerebral cortex | 1.53 | |
| 1.33 | | |||
| Manba | HIP | Hippocampal region | 3.24 | |
| 2.86 | | |||
| Manba | HPF | Hippocampal formation | 2.81 | |
| 2.26 | | |||
| Manba | HY | Hypothalamus | 1.09 | |
| 1 | | |||
| Manba | LSX | Lateral septal complex | 0.17 | |
| 0.27 | | |||
| Manba | MB | Midbrain | 2.09 | |
| 2.34 | | |||
| Manba | MY | Medulla | 5.1 | |
| 5.52 | | |||
| Manba | OLF | Olfactory bulb | 0.74 | |
| 1.42 | | |||
| Manba | P | Pons | 3.7 | |
| 3.89 | | |||
| Manba | PAL | Pallidum | 0.98 | |
| 1.27 | | |||
| Manba | RHP | Retrohippocampal region | 2.27 | |
| 1.56 | | |||
| Manba | sAMY | Striatum-like amygdalar nuclei | 0.65 | |
| 0.6 | | |||
| Manba | STR | Striatum | 2.2 | |
| 2.76 | | |||
| Manba | STRd | Striatum dorsal region | 3.23 | |
| 4.23 | | |||
| Manba | STRv | Striatum ventral region | 0.18 | |
| 0.19 | | |||
| Manba | TH | Thalamus | 9.1 | |
| 7.28 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| MANBA_HUMAN_109 | 17 | 109 | 125 | ILFNEVTIGETDNMFNR | PRIDE |
| MANBA_HUMAN_374 | 15 | 374 | 388 | LLLQSVVDANMNTLR | PRIDE |
| PAp00025378 | 17 | 743 | 759 | GGEAVCLYEEPVSELLR | Peptide Atlas |