AutismKB 2.0

Annotation Detail for MAP4


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Basic Information Top
Gene Symbol:MAP4 ( DKFZp779A1753,MGC8617 )
Gene Full Name: microtubule-associated protein 4
Band: 3p21.31
Quick LinksEntrez ID:4134; OMIM: 157132; Uniprot ID:MAP4_HUMAN; ENSEMBL ID: ENSG00000047849; HGNC ID: 6862
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body30 / 70761423
blastocyst18 / 62319288
fetus125 / 564012221
neonate0 / 310970 
infant1 / 2362042
juvenile4 / 5555671
adult392 / 1939121202
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor20 / 94178212
cervical tumor8 / 34366232
chondrosarcoma30 / 82823362
colorectal tumor34 / 114246297
esophageal tumor1 / 1729057
gastrointestinal tumor28 / 119369234
germ cell tumor36 / 263845136
glioma37 / 106883346
head and neck tumor11 / 13630280
kidney tumor38 / 68959551
leukemia24 / 95842250
liver tumor25 / 96359259
lung tumor18 / 103127174
lymphoma28 / 71755390
non-neoplasia20 / 97250205
normal699 / 3360307208
ovarian tumor11 / 76682143
pancreatic tumor34 / 104616324
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer21 / 102680204
retinoblastoma14 / 46356302
skin tumor39 / 124949312
soft tissue/muscle tissue tumor46 / 125191367
uterine tumor16 / 90257177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland1 / 3319730
ascites4 / 4001599
bladder3 / 29757100
blood19 / 123478153
bone20 / 71655279
bone marrow10 / 48801204
brain372 / 1100989337
cervix10 / 48171207
connective tissue18 / 149255120
ear1 / 1621261
embryonic tissue54 / 215722250
esophagus1 / 2020949
eye71 / 211054336
heart20 / 89626223
intestine58 / 234472247
kidney49 / 211777231
larynx2 / 2414582
liver43 / 207743206
lung44 / 336974130
lymph28 / 44270632
lymph node11 / 91610120
mammary gland29 / 153271189
mouth2 / 6705229
muscle36 / 107715334
nerve7 / 15768443
ovary19 / 102051186
pancreas38 / 214812176
parathyroid2 / 2053997
pharynx6 / 41328145
pituitary gland1 / 1658560
placenta21 / 28082574
prostate37 / 189345195
salivary gland4 / 20155198
skin51 / 210574242
spleen1 / 5395218
stomach16 / 96619165
testis39 / 330442118
thymus5 / 8113161
thyroid4 / 4747384
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus56 / 232878240
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212567_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts86.6
Adipocyte145.5
AdrenalCortex86.55
Adrenalgland59.5
Amygdala178.6
Appendix130.1
AtrioventricularNode167.25
BDCA4+_DentriticCells58.9
Bonemarrow34.4
BronchialEpithelialCells151.7
CD105+_Endothelial22.5
CD14+_Monocytes51.15
CD19+_BCells(neg._sel.)45.15
CD33+_Myeloid50.05
CD34+77.35
CD4+_Tcells72.25
CD56+_NKCells67.55
CD71+_EarlyErythroid21.8
CD8+_Tcells52
CardiacMyocytes243.5
Caudatenucleus235.4
Cerebellum144.15
CerebellumPeduncles278.15
CiliaryGanglion120.4
CingulateCortex374.15
Colorectaladenocarcinoma150.05
DorsalRootGanglion198.75
FetalThyroid207.9
Fetalbrain296.1
Fetalliver41.7
Fetallung86.4
GlobusPallidus131
Heart97.2
Hypothalamus579.4
Kidney74.25
Leukemia_chronicMyelogenousK-56293.15
Leukemia_promyelocytic-HL-60101
Leukemialymphoblastic(MOLT-4)81.25
Liver42.5
Lung164.9
Lymphnode83.05
Lymphoma_burkitts(Daudi)160.55
Lymphoma_burkitts(Raji)126
MedullaOblongata205.8
OccipitalLobe212.45
OlfactoryBulb678.65
Ovary95.3
Pancreas76.8
PancreaticIslet145.2
ParietalLobe224.5
Pituitary102.05
Placenta93.1
Pons209.9
PrefrontalCortex802.8
Prostate113.15
Salivarygland45.9
SkeletalMuscle309.35
Skin96.55
SmoothMuscle253.05
Spinalcord786.15
SubthalamicNucleus306.05
SuperiorCervicalGanglion93.55
TemporalLobe160.55
Testis120.45
TestisGermCell152.75
TestisIntersitial135.55
TestisLeydigCell90.6
TestisSeminiferousTubule118.5
Thalamus756.1
Thymus61.25
Thyroid102.3
Tongue183.85
Tonsil88.65
Trachea60.75
TrigeminalGanglion88.1
Uterus118.3
UterusCorpus43.6
WholeBlood42.15
Wholebrain163.15
colon60.95
pineal_day1341.9
pineal_night1042.94
retina695.05
small_intestine59.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1392_PI416379584
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.2 ± 0.6
Basal Forebrain9.24 ± 0.37
Basal Part of Pons9.73 ± 0.25
Cerebellar Cortex9.91 ± 0.14
Cerebellar Nuclei9.41 ± 0.33
Claustrum9.74 ± 0.39
Epithalamus8.43 ± 1.18
Frontal Lobe9.73 ± 0.36
Globus Pallidus8.01 ± 0.73
Hypothalamus10.16 ± 0.5
Insula9.8 ± 0.2
Limbic Lobe9.28 ± 0.68
Mesencephalon9.39 ± 0.74
Myelencephalon9.29 ± 0.87
Occipital Lobe8.5 ± 0.86
Parietal Lobe9.45 ± 0.43
Pontine Tegmentum9.41 ± 0.76
Striatum7.86 ± 0.68
Subthalamus9.96 ± 0.23
Temporal Lobe9.67 ± 0.37
Thalamus9.77 ± 0.62
White Matter6.59 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mtap4CBCerebellum83.1
100
Mtap4CTXCerebral cortex61.13
57.3
Mtap4HIPHippocampal region92.61
100
Mtap4HPFHippocampal formation76.65
100
Mtap4HYHypothalamus38.8
36.6
Mtap4LSXLateral septal complex66.87
82.24
Mtap4MBMidbrain66.02
76.08
Mtap4MYMedulla54.44
76.18
Mtap4OLFOlfactory bulb58.34
67.28
Mtap4PPons55.11
66.84
Mtap4PALPallidum50.1
55.84
Mtap4RHPRetrohippocampal region53.24
53.18
Mtap4sAMYStriatum-like amygdalar nuclei46.53
42.05
Mtap4STRStriatum29.51
27.1
Mtap4STRdStriatum dorsal region22.69
19.92
Mtap4STRvStriatum ventral region31.15
25.84
Mtap4THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MAP4_HUMAN_2 22 2 23 ADLSLADALTEPSPDIEGEIKR PRIDE
MAP4_HUMAN_224 22 224 245 EIEMASEERPPAQALEIMMGLK PRIDE
MAP4_HUMAN_225 22 225 246 EIEMASEERPPAQALEIMMGLK PRIDE
MAP4_HUMAN_23 21 23 43 DFIATLEAEAFDDVVGETVGK PRIDE
MAP4_HUMAN_255 8 255 262 ETEMALAK PRIDE
MAP4_HUMAN_290 28 290 317 DMQPSMESDMALVKDMELPTEKEVALVK PRIDE
MAP4_HUMAN_291 14 291 304 DMQPSMESDMALVK PRIDE
MAP4_HUMAN_305 8 305 312 DMELPTEK PRIDE
MAP4_HUMAN_369 9 369 377 DMGPPKENK PRIDE
MAP4_HUMAN_403 32 403 434 IVPAKDLVLLSEIEVAQANDIISSTEISSAEK PRIDE
MAP4_HUMAN_435 13 435 447 VALSSETEVALAR PRIDE
MAP4_HUMAN_448 14 448 461 DMTLPPETNVILTK PRIDE
MAP4_HUMAN_449 14 449 462 DMTLPPETNVILTK PRIDE
MAP4_HUMAN_477 14 477 490 DMAQLPETEIAPAK PRIDE
MAP4_HUMAN_519 14 519 532 DVTPPPETEVVLIK PRIDE
MAP4_HUMAN_561 14 561 574 DGVLTLANNVTPAK PRIDE
MAP4_HUMAN_575 25 575 599 DVPPLSETEATPVPIKDMEIAQTQK PRIDE
MAP4_HUMAN_591 9 591 599 DMEIAQTQK PRIDE
MAP4_HUMAN_825 8 825 832 SPSTLLPK PRIDE
MAP4_HUMAN_923 14 923 936 LATNTSAPDLKNVR PRIDE
PAp00001365 13 635 647 CSLPAEEDSVLEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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