AutismKB 2.0

Annotation Detail for MARK1


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Basic Information Top
Gene Symbol:MARK1 ( KIAA1477,MARK,MGC126512,MGC126513 )
Gene Full Name: MAP/microtubule affinity-regulating kinase 1
Band: 1q41
Quick LinksEntrez ID:4139; OMIM: 606511; Uniprot ID:MARK1_HUMAN; ENSEMBL ID: ENSG00000116141; HGNC ID: 6896
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult42 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor9 / 26384534
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal77 / 336030722
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain42 / 110098938
cervix1 / 4817120
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye6 / 21105428
heart2 / 8962622
intestine1 / 2344724
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung18 / 33697453
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth3 / 6705244
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis11 / 33044233
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221047_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.4
Adipocyte8.2
AdrenalCortex11.1
Adrenalgland6.35
Amygdala14.85
Appendix11.9
AtrioventricularNode6.65
BDCA4+_DentriticCells7.85
Bonemarrow8
BronchialEpithelialCells7.65
CD105+_Endothelial7.6
CD14+_Monocytes8.05
CD19+_BCells(neg._sel.)8.2
CD33+_Myeloid9.65
CD34+9.3
CD4+_Tcells7.65
CD56+_NKCells8.7
CD71+_EarlyErythroid7.25
CD8+_Tcells6.55
CardiacMyocytes10.15
Caudatenucleus6.8
Cerebellum7.1
CerebellumPeduncles10.5
CiliaryGanglion7.85
CingulateCortex10.4
Colorectaladenocarcinoma7.4
DorsalRootGanglion9
FetalThyroid8.8
Fetalbrain49.6
Fetalliver7.25
Fetallung6.1
GlobusPallidus10.85
Heart9.85
Hypothalamus13.9
Kidney6.5
Leukemia_chronicMyelogenousK-5626.95
Leukemia_promyelocytic-HL-606.6
Leukemialymphoblastic(MOLT-4)5.9
Liver11.1
Lung8.15
Lymphnode6.9
Lymphoma_burkitts(Daudi)9.5
Lymphoma_burkitts(Raji)11.2
MedullaOblongata10.35
OccipitalLobe13.05
OlfactoryBulb6.25
Ovary6.5
Pancreas7.15
PancreaticIslet11.2
ParietalLobe9.25
Pituitary10.15
Placenta7.15
Pons9.8
PrefrontalCortex9.8
Prostate8.95
Salivarygland8.25
SkeletalMuscle16.7
Skin8.65
SmoothMuscle8.3
Spinalcord8.15
SubthalamicNucleus8.9
SuperiorCervicalGanglion17.7
TemporalLobe10.4
Testis7.55
TestisGermCell17.35
TestisIntersitial13.1
TestisLeydigCell12.9
TestisSeminiferousTubule15.9
Thalamus8.75
Thymus5.75
Thyroid9.6
Tongue12.85
Tonsil8.2
Trachea6.45
TrigeminalGanglion14.15
Uterus6.4
UterusCorpus16.25
WholeBlood8
Wholebrain10.15
colon7.4
pineal_day42.64
pineal_night46.34
retina9.125
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P424
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.94 ± 0.21
Basal Forebrain8.63 ± 0.13
Basal Part of Pons8.86 ± 0.37
Cerebellar Cortex8.46 ± 0.24
Cerebellar Nuclei8.93 ± 0.33
Claustrum8.97 ± 0.44
Epithalamus8.26 ± 0.24
Frontal Lobe8.76 ± 0.31
Globus Pallidus8.37 ± 0.42
Hypothalamus8.72 ± 0.33
Insula8.78 ± 0.14
Limbic Lobe8.88 ± 0.31
Mesencephalon8.75 ± 0.41
Myelencephalon8.64 ± 0.35
Occipital Lobe8.89 ± 0.32
Parietal Lobe8.73 ± 0.34
Pontine Tegmentum8.71 ± 0.34
Striatum8.34 ± 0.44
Subthalamus8.89 ± 0.24
Temporal Lobe8.78 ± 0.27
Thalamus8.62 ± 0.28
White Matter7.92 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mark1CBCerebellum16.15
20.81
Mark1CTXCerebral cortex44.57
32.13
Mark1HIPHippocampal region10.96
10.58
Mark1HPFHippocampal formation13
11.34
Mark1HYHypothalamus5.32
3.81
Mark1LSXLateral septal complex7.02
5.15
Mark1MBMidbrain16.79
15.24
Mark1MYMedulla23.99
25.32
Mark1OLFOlfactory bulb25.79
19.98
Mark1PPons20.98
21.15
Mark1PALPallidum10.91
9.29
Mark1RHPRetrohippocampal region16.61
12.58
Mark1sAMYStriatum-like amygdalar nuclei8.14
5.3
Mark1STRStriatum21.76
15.83
Mark1STRdStriatum dorsal region26.85
20.71
Mark1STRvStriatum ventral region18.35
10.42
Mark1THThalamus9.97
7.95
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00072636 19 213 231 LDTFCGSPPYAAPELFQGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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