AutismKB 2.0

Annotation Detail for MATK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MATK ( CHK,CTK,DKFZp434N1212,HHYLTK,HYL,HYLTK,Lsk,MGC1708,MGC2101 )
Gene Full Name: megakaryocyte-associated tyrosine kinase
Band: 19p13.3
Quick LinksEntrez ID:4145; OMIM: 600038; Uniprot ID:MATK_HUMAN; ENSEMBL ID: ENSG00000007264; HGNC ID: 6906
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus20 / 56401235
neonate4 / 31097128
infant0 / 236200 
juvenile0 / 555560 
adult26 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia8 / 9584283
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal94 / 336030727
ovarian tumor1 / 7668213
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma24 / 46356517
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood19 / 123478153
bone1 / 7165513
bone marrow2 / 4880140
brain57 / 110098951
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye32 / 211054151
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen6 / 53952111
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206267_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.85
Adipocyte6.45
AdrenalCortex8.9
Adrenalgland6.2
Amygdala12.45
Appendix7.75
AtrioventricularNode6.25
BDCA4+_DentriticCells7.65
Bonemarrow7.5
BronchialEpithelialCells6.15
CD105+_Endothelial6.15
CD14+_Monocytes6.4
CD19+_BCells(neg._sel.)7.6
CD33+_Myeloid8.45
CD34+24.6
CD4+_Tcells97.2
CD56+_NKCells457.35
CD71+_EarlyErythroid5.9
CD8+_Tcells145.05
CardiacMyocytes8.85
Caudatenucleus10.75
Cerebellum6.1
CerebellumPeduncles8.4
CiliaryGanglion4.95
CingulateCortex13.2
Colorectaladenocarcinoma6.35
DorsalRootGanglion5.55
FetalThyroid6.8
Fetalbrain13.2
Fetalliver5.75
Fetallung5.4
GlobusPallidus12.25
Heart9.05
Hypothalamus7.15
Kidney8.7
Leukemia_chronicMyelogenousK-56216.85
Leukemia_promyelocytic-HL-606.2
Leukemialymphoblastic(MOLT-4)6.55
Liver8.95
Lung8.3
Lymphnode7.85
Lymphoma_burkitts(Daudi)10.05
Lymphoma_burkitts(Raji)10.6
MedullaOblongata8.2
OccipitalLobe9.5
OlfactoryBulb5.3
Ovary4.75
Pancreas5.5
PancreaticIslet7.25
ParietalLobe11.85
Pituitary10.8
Placenta6.3
Pons9.1
PrefrontalCortex12.35
Prostate7.45
Salivarygland5.8
SkeletalMuscle10.45
Skin8.95
SmoothMuscle7.2
Spinalcord8.15
SubthalamicNucleus16.5
SuperiorCervicalGanglion8
TemporalLobe14.6
Testis5.55
TestisGermCell5.15
TestisIntersitial5.9
TestisLeydigCell6.7
TestisSeminiferousTubule5.85
Thalamus11.1
Thymus5
Thyroid8.1
Tongue8.55
Tonsil10.25
Trachea7
TrigeminalGanglion10.1
Uterus4.95
UterusCorpus6
WholeBlood11.55
Wholebrain19.95
colon5.8
pineal_day7.54
pineal_night7.74
retina7.325
small_intestine5.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10167_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.25 ± 0.94
Basal Forebrain4.99 ± 0.84
Basal Part of Pons6.16 ± 0.47
Cerebellar Cortex4.46 ± 0.55
Cerebellar Nuclei4.58 ± 0.58
Claustrum4.39 ± 1.21
Epithalamus4.74 ± 0.83
Frontal Lobe5.65 ± 0.76
Globus Pallidus4.26 ± 1.25
Hypothalamus5.45 ± 0.89
Insula5.53 ± 0.51
Limbic Lobe5.55 ± 0.84
Mesencephalon4.9 ± 0.79
Myelencephalon5.15 ± 0.95
Occipital Lobe4.55 ± 1
Parietal Lobe5.45 ± 0.82
Pontine Tegmentum5.04 ± 0.67
Striatum4.82 ± 1.18
Subthalamus4.97 ± 0.4
Temporal Lobe5.59 ± 0.63
Thalamus4.54 ± 0.76
White Matter2.45 ± 0.95
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MatkCBCerebellum29.78
32.78
MatkCTXCerebral cortex100
100
MatkHIPHippocampal region100
100
MatkHPFHippocampal formation100
100
MatkHYHypothalamus100
100
MatkLSXLateral septal complex100
100
MatkMBMidbrain100
100
MatkMYMedulla100
100
MatkOLFOlfactory bulb100
100
MatkPPons100
100
MatkPALPallidum100
100
MatkRHPRetrohippocampal region100
100
MatksAMYStriatum-like amygdalar nuclei100
100
MatkSTRStriatum100
100
MatkSTRdStriatum dorsal region100
100
MatkSTRvStriatum ventral region100
100
MatkTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00074110 10 117 126 LSLMPWFHGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved