AutismKB 2.0

Annotation Detail for MBP


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Basic Information Top
Gene Symbol:MBP ( MGC99675 )
Gene Full Name: myelin basic protein
Band: 18q23
Quick LinksEntrez ID:4155; OMIM: 159430; Uniprot ID:MBP_HUMAN; ENSEMBL ID: ENSG00000197971; HGNC ID: 6925
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus73 / 564012129
neonate3 / 3109796
infant26 / 236201100
juvenile21 / 55556377
adult2393 / 19391211234
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor9 / 26384534
glioma17 / 106883159
head and neck tumor8 / 13630258
kidney tumor1815 / 6895926319
leukemia10 / 95842104
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia1551 / 9725015948
normal17112 / 33603075092
ovarian tumor0 / 766820 
pancreatic tumor9 / 10461686
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor104 / 124949832
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites5 / 40015124
bladder0 / 297570 
blood18 / 123478145
bone2 / 7165527
bone marrow3 / 4880161
brain18991 / 110098917249
cervix1 / 4817120
connective tissue7 / 14925546
ear18 / 162121110
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye18 / 21105485
heart6 / 8962666
intestine16 / 23447268
kidney1826 / 2117778622
larynx3 / 24145124
liver5 / 20774324
lung32 / 33697494
lymph1 / 4427022
lymph node36 / 91610392
mammary gland3 / 15327119
mouth5 / 6705274
muscle12 / 107715111
nerve57 / 157683614
ovary0 / 1020510 
pancreas25 / 214812116
parathyroid24 / 205391168
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta9 / 28082532
prostate13 / 18934568
salivary gland0 / 201550 
skin148 / 210574702
spleen4 / 5395274
stomach0 / 966190 
testis3 / 3304429
thymus5 / 8113161
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207323_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.45
Adipocyte7.95
AdrenalCortex11.8
Adrenalgland6.55
Amygdala1153.8
Appendix7.85
AtrioventricularNode244.25
BDCA4+_DentriticCells7.4
Bonemarrow7.85
BronchialEpithelialCells7.45
CD105+_Endothelial7.65
CD14+_Monocytes7.65
CD19+_BCells(neg._sel.)7.7
CD33+_Myeloid9.15
CD34+10.6
CD4+_Tcells8.45
CD56+_NKCells8.9
CD71+_EarlyErythroid12.3
CD8+_Tcells7.65
CardiacMyocytes10.15
Caudatenucleus3032.4
Cerebellum1271.65
CerebellumPeduncles8179.05
CiliaryGanglion114.65
CingulateCortex5197.2
Colorectaladenocarcinoma7.8
DorsalRootGanglion615.1
FetalThyroid8.05
Fetalbrain7.75
Fetalliver8.85
Fetallung6.2
GlobusPallidus2449.7
Heart17.45
Hypothalamus6960.25
Kidney6.4
Leukemia_chronicMyelogenousK-5627.05
Leukemia_promyelocytic-HL-606.7
Leukemialymphoblastic(MOLT-4)6.5
Liver11.2
Lung17.25
Lymphnode6.45
Lymphoma_burkitts(Daudi)10.05
Lymphoma_burkitts(Raji)11.15
MedullaOblongata9322.1
OccipitalLobe9297.2
OlfactoryBulb7096.15
Ovary5.5
Pancreas6.15
PancreaticIslet8
ParietalLobe14091.7
Pituitary14
Placenta7.85
Pons5692.6
PrefrontalCortex13188.05
Prostate8.55
Salivarygland6.5
SkeletalMuscle13.75
Skin5.9
SmoothMuscle7.65
Spinalcord13199.8
SubthalamicNucleus2532.3
SuperiorCervicalGanglion498.3
TemporalLobe3023.7
Testis6.75
TestisGermCell6.45
TestisIntersitial6.65
TestisLeydigCell7.8
TestisSeminiferousTubule6.55
Thalamus4780.95
Thymus5.9
Thyroid9.55
Tongue7.65
Tonsil7.1
Trachea12.5
TrigeminalGanglion174.5
Uterus6.25
UterusCorpus7.2
WholeBlood8.55
Wholebrain5328.05
colon8.4
pineal_day84.32
pineal_night26.88
retina7652.95
small_intestine7.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15871_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.23 ± 0.54
Basal Forebrain5.78 ± 0.22
Basal Part of Pons4.76 ± 0.4
Cerebellar Cortex5.18 ± 0.51
Cerebellar Nuclei6.08 ± 0.29
Claustrum5.52 ± 0.55
Epithalamus6.02 ± 0.56
Frontal Lobe5.76 ± 0.66
Globus Pallidus6.3 ± 0.84
Hypothalamus5.59 ± 0.36
Insula5.98 ± 0.42
Limbic Lobe6.72 ± 0.71
Mesencephalon6.15 ± 0.57
Myelencephalon5.98 ± 0.73
Occipital Lobe7.14 ± 0.78
Parietal Lobe6.36 ± 0.56
Pontine Tegmentum6.43 ± 0.62
Striatum5.24 ± 1.2
Subthalamus5.79 ± 0.38
Temporal Lobe6.24 ± 0.5
Thalamus5.21 ± 0.61
White Matter5.97 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MbpCBCerebellum100
100
MbpCTXCerebral cortex100
100
MbpHIPHippocampal region100
100
MbpHPFHippocampal formation100
100
MbpHYHypothalamus100
97.3
MbpLSXLateral septal complex100
95.65
MbpMBMidbrain100
100
MbpMYMedulla100
100
MbpOLFOlfactory bulb100
100
MbpPPons100
100
MbpPALPallidum100
100
MbpRHPRetrohippocampal region100
100
MbpsAMYStriatum-like amygdalar nuclei100
99.81
MbpSTRStriatum100
100
MbpSTRdStriatum dorsal region100
100
MbpSTRvStriatum ventral region100
100
MbpTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00038423 32 38 69 TTSEDNEVFGEADANQNNGTSSQDTAVTDSKR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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