AutismKB 2.0

Annotation Detail for MCC


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Basic Information Top
Gene Symbol:MCC ( DKFZp762O1615,FLJ38893,FLJ46755,MCC1 )
Gene Full Name: mutated in colorectal cancers
Band: 5q22.2
Quick LinksEntrez ID:4163; OMIM: 159350; Uniprot ID:CRCM_HUMAN; ENSEMBL ID: ENSG00000171444; HGNC ID: 6935
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult65 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal114 / 336030733
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer1 / 1026809
retinoblastoma7 / 46356151
skin tumor11 / 12494988
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder2 / 2975767
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain23 / 110098920
cervix0 / 481710 
connective tissue1 / 1492556
ear4 / 16212246
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye29 / 211054137
heart4 / 8962644
intestine2 / 2344728
kidney3 / 21177714
larynx2 / 2414582
liver10 / 20774348
lung13 / 33697438
lymph0 / 442700 
lymph node1 / 9161010
mammary gland5 / 15327132
mouth1 / 6705214
muscle6 / 10771555
nerve0 / 157680 
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta7 / 28082524
prostate4 / 18934521
salivary gland1 / 2015549
skin25 / 210574118
spleen1 / 5395218
stomach1 / 9661910
testis4 / 33044212
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus4 / 23287817
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206132_at
Cell line Expression level Expression bar
721_B_lymphoblasts20.25
Adipocyte29.7
AdrenalCortex30.65
Adrenalgland27.4
Amygdala32
Appendix32.6
AtrioventricularNode22
BDCA4+_DentriticCells33
Bonemarrow37.8
BronchialEpithelialCells29.95
CD105+_Endothelial10.3
CD14+_Monocytes12.1
CD19+_BCells(neg._sel.)19.55
CD33+_Myeloid13.5
CD34+21.4
CD4+_Tcells28.45
CD56+_NKCells9.95
CD71+_EarlyErythroid17.5
CD8+_Tcells19.4
CardiacMyocytes41.95
Caudatenucleus26.85
Cerebellum35.55
CerebellumPeduncles34.9
CiliaryGanglion20.25
CingulateCortex30.45
Colorectaladenocarcinoma28.75
DorsalRootGanglion26.7
FetalThyroid28.85
Fetalbrain30.3
Fetalliver40.95
Fetallung23.3
GlobusPallidus21.55
Heart41.25
Hypothalamus31
Kidney26.2
Leukemia_chronicMyelogenousK-56226
Leukemia_promyelocytic-HL-6025.75
Leukemialymphoblastic(MOLT-4)22.9
Liver42.5
Lung31.6
Lymphnode26.2
Lymphoma_burkitts(Daudi)38.35
Lymphoma_burkitts(Raji)42.45
MedullaOblongata27.6
OccipitalLobe26.3
OlfactoryBulb31.65
Ovary21.75
Pancreas24.65
PancreaticIslet32.9
ParietalLobe31.7
Pituitary36.1
Placenta31.15
Pons28.8
PrefrontalCortex35.85
Prostate35.65
Salivarygland23.75
SkeletalMuscle42.05
Skin25.65
SmoothMuscle36.95
Spinalcord31.7
SubthalamicNucleus29.7
SuperiorCervicalGanglion71
TemporalLobe26.95
Testis26.85
TestisGermCell22.4
TestisIntersitial24.75
TestisLeydigCell31.85
TestisSeminiferousTubule25.6
Thalamus30.2
Thymus24
Thyroid38.05
Tongue29.9
Tonsil28.9
Trachea25.15
TrigeminalGanglion33.7
Uterus24.95
UterusCorpus30.15
WholeBlood27.2
Wholebrain25.5
colon30.3
pineal_day77.04
pineal_night67.4
retina42.275
small_intestine36.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P377115
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.28 ± 0.57
Basal Forebrain4.72 ± 0.43
Basal Part of Pons4.03 ± 0.38
Cerebellar Cortex4.37 ± 0.63
Cerebellar Nuclei4.26 ± 0.64
Claustrum3.73 ± 0.5
Epithalamus4.78 ± 0.51
Frontal Lobe4.37 ± 0.54
Globus Pallidus5.96 ± 0.51
Hypothalamus4.78 ± 0.45
Insula4.43 ± 0.52
Limbic Lobe4.33 ± 0.66
Mesencephalon4.95 ± 0.62
Myelencephalon4.47 ± 0.72
Occipital Lobe4.92 ± 0.68
Parietal Lobe4.63 ± 0.64
Pontine Tegmentum4.6 ± 0.62
Striatum4.26 ± 0.6
Subthalamus4.26 ± 0.21
Temporal Lobe4.39 ± 0.56
Thalamus4.87 ± 0.6
White Matter4.04 ± 0.52
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
MccCBCerebellum15.38
20.83
MccCTXCerebral cortex0.98
0.87
MccHIPHippocampal region0.69
0.61
MccHPFHippocampal formation0.87
0.98
MccHYHypothalamus0.22
0.24
MccLSXLateral septal complex0.09
0.08
MccMBMidbrain0.96
1.21
MccMYMedulla5.18
5.81
MccOLFOlfactory bulb0.88
0.84
MccPPons1.34
1.98
MccPALPallidum1.62
1.6
MccRHPRetrohippocampal region1.17
1.34
MccsAMYStriatum-like amygdalar nuclei0.12
0.18
MccSTRStriatum0.16
0.22
MccSTRdStriatum dorsal region0.11
0.2
MccSTRvStriatum ventral region0.3
0.31
MccTHThalamus0.35
0.36
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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