AutismKB 2.0

Annotation Detail for MCL1


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Basic Information Top
Gene Symbol:MCL1 ( BCL2L3,EAT,MCL1-ES,MCL1L,MCL1S,MGC104264,MGC1839,Mcl-1,TM,bcl2-L-3,mcl1/EAT )
Gene Full Name: myeloid cell leukemia sequence 1 (BCL2-related)
Band: 1q21.2
Quick LinksEntrez ID:4170; OMIM: 159552; Uniprot ID:MCL1_HUMAN; ENSEMBL ID: ENSG00000143384; HGNC ID: 6943
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst13 / 62319208
fetus97 / 564012171
neonate2 / 3109764
infant1 / 2362042
juvenile16 / 55556287
adult450 / 1939121232
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma3 / 17475171
breast (mammary gland) tumor13 / 94178138
cervical tumor7 / 34366203
chondrosarcoma26 / 82823313
colorectal tumor14 / 114246122
esophageal tumor5 / 17290289
gastrointestinal tumor30 / 119369251
germ cell tumor82 / 263845310
glioma11 / 106883102
head and neck tumor41 / 136302300
kidney tumor8 / 68959116
leukemia22 / 95842229
liver tumor18 / 96359186
lung tumor17 / 103127164
lymphoma11 / 71755153
non-neoplasia13 / 97250133
normal591 / 3360307175
ovarian tumor28 / 76682365
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer4 / 10268038
retinoblastoma7 / 46356151
skin tumor12 / 12494996
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor84 / 90257930
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland6 / 33197180
ascites6 / 40015149
bladder10 / 29757336
blood56 / 123478453
bone30 / 71655418
bone marrow7 / 48801143
brain109 / 110098999
cervix10 / 48171207
connective tissue20 / 149255133
ear4 / 16212246
embryonic tissue41 / 215722190
esophagus5 / 20209247
eye35 / 211054165
heart11 / 89626122
intestine39 / 234472166
kidney35 / 211777165
larynx2 / 2414582
liver42 / 207743202
lung62 / 336974183
lymph5 / 44270112
lymph node50 / 91610545
mammary gland29 / 153271189
mouth29 / 67052432
muscle10 / 10771592
nerve9 / 15768570
ovary27 / 102051264
pancreas30 / 214812139
parathyroid3 / 20539146
pharynx3 / 4132872
pituitary gland2 / 16585120
placenta62 / 280825220
prostate11 / 18934558
salivary gland1 / 2015549
skin20 / 21057494
spleen10 / 53952185
stomach31 / 96619320
testis80 / 330442242
thymus23 / 81131283
thyroid10 / 47473210
tonsil1 / 1699958
trachea38 / 52413725
umbilical cord0 / 136800 
uterus133 / 232878571
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200797_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts835.8
Adipocyte471.15
AdrenalCortex1041.65
Adrenalgland433.85
Amygdala286.25
Appendix529.35
AtrioventricularNode370.75
BDCA4+_DentriticCells2707.05
Bonemarrow582.15
BronchialEpithelialCells1268.95
CD105+_Endothelial1113.65
CD14+_Monocytes3237.95
CD19+_BCells(neg._sel.)1449.2
CD33+_Myeloid7677
CD34+1940.4
CD4+_Tcells3159.7
CD56+_NKCells1961.1
CD71+_EarlyErythroid515.8
CD8+_Tcells2892.75
CardiacMyocytes444.85
Caudatenucleus152.55
Cerebellum142.4
CerebellumPeduncles172.45
CiliaryGanglion379.3
CingulateCortex234.55
Colorectaladenocarcinoma312.4
DorsalRootGanglion211.4
FetalThyroid829.7
Fetalbrain452.85
Fetalliver387.95
Fetallung1040
GlobusPallidus72.75
Heart224.05
Hypothalamus437.3
Kidney180.75
Leukemia_chronicMyelogenousK-562640.8
Leukemia_promyelocytic-HL-60648.85
Leukemialymphoblastic(MOLT-4)251.55
Liver190.8
Lung993.5
Lymphnode1044.3
Lymphoma_burkitts(Daudi)830.7
Lymphoma_burkitts(Raji)702.7
MedullaOblongata171.8
OccipitalLobe182.8
OlfactoryBulb666.25
Ovary179.45
Pancreas548.85
PancreaticIslet1149.55
ParietalLobe88.85
Pituitary672.1
Placenta1261.9
Pons123.7
PrefrontalCortex450.85
Prostate672.25
Salivarygland498.35
SkeletalMuscle381.85
Skin473.85
SmoothMuscle983.15
Spinalcord539.85
SubthalamicNucleus77.65
SuperiorCervicalGanglion353.3
TemporalLobe118
Testis277.4
TestisGermCell477.15
TestisIntersitial262.9
TestisLeydigCell280.75
TestisSeminiferousTubule287.65
Thalamus222.2
Thymus652.35
Thyroid1049.1
Tongue683.95
Tonsil988
Trachea588.25
TrigeminalGanglion420.05
Uterus736.25
UterusCorpus712.45
WholeBlood5241.2
Wholebrain210.55
colon566.7
pineal_day638.52
pineal_night614.92
retina843.25
small_intestine579.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P319635
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.06 ± 0.42
Basal Forebrain7.07 ± 0.23
Basal Part of Pons6.44 ± 0.28
Cerebellar Cortex6.96 ± 0.25
Cerebellar Nuclei7.68 ± 0.34
Claustrum7.21 ± 0.46
Epithalamus7.16 ± 0.49
Frontal Lobe6.81 ± 0.52
Globus Pallidus8.1 ± 0.32
Hypothalamus6.84 ± 0.85
Insula6.94 ± 0.33
Limbic Lobe6.89 ± 0.41
Mesencephalon7.19 ± 0.35
Myelencephalon7.05 ± 0.49
Occipital Lobe7.29 ± 0.35
Parietal Lobe6.92 ± 0.39
Pontine Tegmentum7.16 ± 0.42
Striatum7.52 ± 0.57
Subthalamus7.17 ± 0.32
Temporal Lobe6.83 ± 0.4
Thalamus7.19 ± 0.39
White Matter7.73 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mcl1CBCerebellum20.64
32.11
Mcl1CTXCerebral cortex58.9
56.19
Mcl1HIPHippocampal region54.8
61.71
Mcl1HPFHippocampal formation60.47
59.44
Mcl1HYHypothalamus26.91
24.05
Mcl1LSXLateral septal complex52.07
50.79
Mcl1MBMidbrain37
39.77
Mcl1MYMedulla30.85
39.15
Mcl1OLFOlfactory bulb64.34
61.93
Mcl1PPons29.47
36.71
Mcl1PALPallidum30.09
28.94
Mcl1RHPRetrohippocampal region58.28
56.31
Mcl1sAMYStriatum-like amygdalar nuclei28.48
23.65
Mcl1STRStriatum34.62
29.1
Mcl1STRdStriatum dorsal region31.03
25.91
Mcl1STRvStriatum ventral region41.28
33.23
Mcl1THThalamus28.21
25.74
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MCL1_HUMAN_223 11 223 233 NHETAFQGMLR PRIDE
PAp00131565 20 76 95 VARPPPIGAEVPDVTATPAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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